Similar burden of pathogenic coding variants in exceptionally long-lived individuals and individuals without exceptional longevity.

Danielle Gutman, Gabriel Lidzbarsky, Sofiya Milman, Tina Gao, Patrick Sin-Chan, Claudia Gonzaga-Jauregui, , Joris Deelen, Alan R Shuldiner, Nir Barzilai, Gil Atzmon

October 2020 Aging Cell

Synopsis of Social media discussions

Discussions reflect a high level of interest and engagement, with posts highlighting key insights like the lack of fewer mutations in long-lived individuals, paralleling past studies and emphasizing the need to explore other genetic or lifestyle factors. Phrases such as 'supporting the dominance of longevity genes' and references to implications for aging research showcase a thoughtful and impactful dialogue surrounding the publication.

A
Agreement
 Moderate agreement

Most discussions acknowledge and support the findings that longevity isn't solely determined by having fewer harmful genetic variants, often referencing previous research and reinforcing the study's conclusions.

I
Interest
 High level of interest

The talks demonstrate high curiosity about the genetics of longevity and aging, with many posts emphasizing the implications for understanding health in old age.

E
Engagement
 High engagement

Participants reference specific aspects of the research, such as the similar mutation burdens and the role of other factors, indicating deep engagement with the content.

I
Impact
 Moderate level of impact

The discourse suggests the findings could influence future research directions in aging genetics and challenge traditional views about genetic mutation burdens contributing to longevity.

Social Mentions

YouTube

2 Videos

Facebook

2 Posts

Twitter

23 Posts

Blogs

4 Articles

News

18 Articles

Reddit

2 Posts

Metrics

Video Views

3,806

Total Likes

239

Extended Reach

160,021

Social Features

51

Timeline: Posts about article

Top Social Media Posts

Posts referencing the article

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Centenarians Carry Similar Pathogenic Mutations as Others

Centenarians Carry Similar Pathogenic Mutations as Others

Centenarians show remarkable longevity despite having a similar burden of harmful genetic mutations as their peers, indicating other factors contribute to their extended lifespan, according to recent genetic studies.

Lifespan Research Institute

September 15, 2020

1,293 views

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Abstract Synopsis

  • Centenarians show a surprising longevity and health despite having similar genetic mutation burdens compared to their peers, revealed through whole exome sequencing of 1,879 individuals, including ELLI, their offspring, and controls.
  • Analyses found no significant differences in the types or frequencies of harmful genetic variants between centenarians and non-centenarian controls, indicating that being a centenarian is not linked to having fewer harmful mutations.
  • Notably, ELLI displayed a lower presence of cancer and Alzheimer’s-associated variants, hinting that their longevity may be influenced by other genomic or lifestyle factors rather than simply a lack of harmful mutations.