Publications by authors named "Patrick Spence"

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Refining the in vitro release test method for a dapivirine-releasing vaginal ring to match in vivo performance.
Diarmaid J Murphy, Deanna Lim, Ryan Armstrong, Clare F McCoy, Yahya H Dallal Bashi, Patrick Spence

Drug Deliv Transl Res· August 2023

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drug release, mechanical performance and stability testing of a custom silicone elastomer vaginal ring releasing dapivirine and levonorgestrel.
Diarmaid J Murphy, Yahya H Dallal Bashi, Clare F McCoy, Peter Boyd, Leeanne Brown, Patrick Spence

Int J Pharm X· December 2022

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Use of simulated vaginal and menstrual fluids to model discolouration of silicone elastomer vaginal rings.
Clare F McCoy, Patrick Spence, Yahya H Dallal Bashi, Diarmaid J Murphy, Peter Boyd

Int J Pharm X· December 2021

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Silicone elastomer formulations for improved performance of a multipurpose vaginal ring releasing dapivirine and levonorgestrel.
Yahya H Dallal Bashi, Diarmaid J Murphy, Clare F McCoy, Peter Boyd, Leeanne Brown, Patrick Spence

Int J Pharm X· December 2021

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Phase 1 pharmacokinetics and safety study of extended duration dapivirine vaginal rings in the United States.
Albert Y Liu, Clara Dominguez Islas, Holly Gundacker, Blazej Neradilek, Craig Hoesley, Patrick Spence

J Int AIDS Soc· June 2021

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In vitro release testing methods for drug-releasing vaginal rings.
Peter Boyd, Bruce Variano, Patrick Spence, Clare F McCoy, Diarmaid J Murphy

J Control Release· November 2019

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Towards a dapivirine and levonorgestrel multipurpose vaginal ring: Investigations into the reaction between levonorgestrel and addition-cure silicone elastomers.
Yahya H Dallal Bashi, Clare F McCoy, Diarmaid J Murphy, Peter Boyd, Patrick Spence

Int J Pharm· October 2019

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Drug stability and product performance characteristics of a dapivirine-releasing vaginal ring under simulated real-world conditions.
Diarmaid J Murphy, Clare F McCoy, Peter Boyd, Tiffany Derrick, Patrick Spence

Int J Pharm· June 2019

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Packing Polymorphism of Dapivirine and Its Impact on the Performance of a Dapivirine-Releasing Silicone Elastomer Vaginal Ring.
Clare F McCoy, Diarmaid J Murphy, Peter Boyd, Tiffany Derrick, Patrick Spence

J Pharm Sci· August 2017

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Safety and Efficacy of a Dapivirine Vaginal Ring for HIV Prevention in Women.
Annalene Nel, Neliëtte van Niekerk, Saidi Kapiga, Linda-Gail Bekker, Cynthia Gama, Patrick Spence

N Engl J Med· December 2016

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Fibroblast Growth Factor Receptor-Dependent and -Independent Paracrine Signaling by Sunitinib-Resistant Renal Cell Carcinoma.
Tram Anh Tran, Hon Sing Leong, Andrea Pavia-Jimenez, Slavic Fedyshyn, Juan Yang, Patrick Spence

Mol Cell Biol· July 2016

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Post-use assay of vaginal rings (VRs) as a potential measure of clinical trial adherence.
Patrick Spence, Annalene Nel, Neliëtte van Niekerk, Tiffany Derrick, Susan Wilder

J Pharm Biomed Anal· June 2016

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Recent work on vaginal rings containing antiviral agents for HIV prevention.
Patrick Spence, Anita Bhatia Garg, Cynthia Woodsong, Brid Devin, Zeda Rosenberg

Curr Opin HIV AIDS· July 2015

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A validated tumorgraft model reveals activity of dovitinib against renal cell carcinoma.
Sharanya Sivanand, Samuel Peña-Llopis, Hong Zhao, Blanka Kucejova, Patrick Spence

Sci Transl Med· June 2012

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BAP1 loss defines a new class of renal cell carcinoma.
Samuel Peña-Llopis, Silvia Vega-Rubín-de-Celis, Arnold Liao, Nan Leng, Andrea Pavía-Jiménez, Patrick Spence

Nat Genet· June 2012

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