Publications by authors named "Paul Arras"

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Enhancing NK cell-mediated tumor killing of B7-H6 cells with bispecific antibodies targeting allosteric sites of NKp30.
Léxane Fournier, Paul Arras, Lukas Pekar, Harald Kolmar, Stefan Zielonka

Mol Ther Oncol· March 2025

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Taming interleukin-12: Engineering of bispecific antibody-based IL-12 mimetics with biased agonism capacities.
Britta Lipinski, Laura Unmuth, Paul Arras, Ron Endruszeit, Stefan Becker

Protein Sci· March 2025

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Bovine ultralong CDR-H3 derived knob paratopes elicit potent TNF-α neutralization and enable the generation of novel adalimumab-based antibody architectures with augmented features.
Paul Arras, Jasmin Zimmermann, Britta Lipinski, Bernhard Valldorf, Andreas Evers

Biol Chem· July 2024

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Generation and engineering of potent single domain antibody-based bispecific IL-18 mimetics resistant to IL-18BP decoy receptor inhibition.
Britta Lipinski, Laura Unmuth, Paul Arras, Stefan Becker, Christina Bauer

MAbs· November 2023

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A library approach for the high-throughput isolation of humanized VHH domains with favorable developability properties following camelid immunization.
Paul Arras, Han Byul Yoo, Lukas Pekar, Christian Schröter, Thomas Clarke

MAbs· November 2023

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Cattle-derived knob paratopes grafted onto peripheral loops of the IgG1 Fc region enable the generation of a novel symmetric bispecific antibody format.
Desislava Yanakieva, Lena Vollmer, Andreas Evers, Vanessa Siegmund, Paul Arras

Front Immunol· November 2023

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AI/ML combined with next-generation sequencing of VHH immune repertoires enables the rapid identification of humanized and sequence-optimized single domain antibodies: a prospective case study.
Paul Arras, Han Byul Yoo, Lukas Pekar, Thomas Clarke, Lukas Friedrich

Front Mol Biosci· September 2023

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Isolation of Antigen-Specific Unconventional Bovine Ultra-Long CDR3H Antibodies Using Cattle Immunization in Combination with Yeast Surface Display.
Paul Arras, Jasmin Zimmermann, Britta Lipinski, Desislava Yanakieva, Daniel Klewinghaus

Methods Mol Biol· July 2023

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Affinity Maturation of the Natural Ligand (B7-H6) for Natural Cytotoxicity Receptor NKp30 by Yeast Surface Display.
Stefan Zielonka, Simon Krah, Paul Arras, Britta Lipinski, Jasmin Zimmermann

Methods Mol Biol· July 2023

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NKp46-specific single domain antibodies enable facile engineering of various potent NK cell engager formats.
Britta Lipinski, Paul Arras, Lukas Pekar, Daniel Klewinghaus, Ammelie Svea Boje

Protein Sci· March 2023

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Grabbing the Bull by Both Horns: Bovine Ultralong CDR-H3 Paratopes Enable Engineering of 'Almost Natural' Common Light Chain Bispecific Antibodies Suitable For Effector Cell Redirection.
Daniel Klewinghaus, Lukas Pekar, Paul Arras, Simon Krah, Bernhard Valldorf

Front Immunol· February 2022

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Milking the Cow: Cattle-Derived Chimeric Ultralong CDR-H3 Antibodies and Their Engineered CDR-H3-Only Knobbody Counterparts Targeting Epidermal Growth Factor Receptor Elicit Potent NK Cell-Mediated Cytotoxicity.
Lukas Pekar, Daniel Klewinghaus, Paul Arras, Stefania C Carrara, Julia Harwardt

Front Immunol· December 2021

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