Publications by authors named "Paul B Yu"

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BMP9 regulates the endothelial secretome to drive pulmonary hypertension.
Ying Zhong, Peiran Yang, Luca Troncone, Oleg V Kovalenko, Eva M Fast, Paul B Yu

bioRxiv· September 2025

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Shear stress unveils patient-specific transcriptional signatures in PAH: Towards personalized molecular diagnostics.
Corey Wittig, Jakob M König, Xiaoke Pan, Jurjan Aman, Harm-Jan Bogaard, Paul B Yu

Theranostics· May 2025

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Acute regulation of murine adipose tissue lipolysis and insulin resistance by the TGFβ superfamily protein GDF3.
Nagasuryaprasad Kotikalapudi, Deepti Ramachandran, Daniel Vieira, William B Rubio, Gregory R Gipson, Paul B Yu

Nat Commun· May 2025

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Cross-species analysis of experimental PH at single cell resolution reveals prominent contributions EC and macrophage populations.
Bolun Li, Yanjiang Xing, Yitian Zhou, Xingqi Xiao, Ting Shu, Paul B Yu

bioRxiv· May 2025

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Endothelial ActRIIA inhibition protects the cardiac microvasculature in severe viral respiratory infection.
Peng Xia, Sujin Lee, Kangsan Roh, Jason Griffith, Yirong Zhou, Yugene Y Guo, Paul B Yu

Res Sq· April 2025

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Hepatopulmonary Syndrome, Another Face of Dysregulated BMP9 Signaling.
Shreya Sangam, Paul B Yu

Am J Respir Crit Care Med· September 2024

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FAM222A, Part of the BET-Regulated Basal Endothelial Transcriptome, Is a Novel Determinant of Endothelial Biology and Angiogenesis-Brief Report.
Aspasia Tzani, Stefan Haemmig, Henry S Cheng, Daniel Pérez-Cremades, Marina Augusto Heuschkel, Paul B Yu

Arterioscler Thromb Vasc Biol· January 2024

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Novel Imaging Approaches to Cardiac Manifestations of Systemic Inflammatory Diseases: JACC Scientific Statement.
Brittany N Weber, Julie J Paik, Ayaz Aghayev, Allan L Klein, Sophie I Mavrogeni, Paul B Yu

J Am Coll Cardiol· November 2023

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Angiogenesis Redux: An Overall Protective Role of VEGF/KDR Signaling in the Microvasculature in Pulmonary Arterial Hypertension.
Ying Zhong, Paul B Yu

Arterioscler Thromb Vasc Biol· October 2023

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Intrapulmonary arterial contraction assay reveals region-specific deregulation of vasoreactivity to lung injuries.
Yan Bai, Guang Li, Laiming Yung, Paul B Yu, Xingbin Ai

Am J Physiol Lung Cell Mol Physiol· August 2023

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Cationic proteins from eosinophils bind bone morphogenetic protein receptors promoting vascular calcification and atherogenesis.
Zhaojie Meng, Shuya Zhang, Wei Li, Yunzhe Wang, Minjie Wang, Paul B Yu

Eur Heart J· August 2023

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Wnt7a deficit is associated with dysfunctional angiogenesis in pulmonary arterial hypertension.
Ananya Chakraborty, Abinaya Nathan, Mark Orcholski, Stuti Agarwal, Elya A Shamskhou, Joyce Yu, Ke Yuan, Lai-Ming Yung, Paul B Yu

Eur Respir J· June 2023

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Diminished muscle integrity in patients with fibrodysplasia ossificans progressiva assessed with at-home electrical impedance myography.
Alexander Farid, Emma Golden, Sara Robicheau, Alice Hu, Kin Cheung, Paul B Yu

Sci Rep· December 2022

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Decoding the Link Between Inflammation and Pulmonary Arterial Hypertension.
Ying Zhong, Paul B Yu

Circulation· September 2022

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Anti-ACVR1 antibodies exacerbate heterotopic ossification in fibrodysplasia ossificans progressiva (FOP) by activating FOP-mutant ACVR1.
Senem Aykul, Lily Huang, Lili Wang, Nanditha M Das, Sandra Reisman, Paul B Yu

J Clin Invest· June 2022

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Protocol paper: a multi-center, double-blinded, randomized, 6-month, placebo-controlled study followed by 12-month open label extension to evaluate the safety and efficacy of Saracatinib in Fibrodysplasia Ossificans Progressiva (STOPFOP).
Bernard J Smilde, Clemens Stockklausner, Richard Keen, Andrew Whittaker, Alex N Bullock, Paul B Yu

BMC Musculoskelet Disord· June 2022

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Sotatercept analog suppresses inflammation to reverse experimental pulmonary arterial hypertension.
Sachindra R Joshi, Jun Liu, Troy Bloom, Elif Karaca Atabay, Tzu-Hsing Kuo, Paul B Yu

Sci Rep· May 2022

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Novel Approaches to Imaging the Pulmonary Vasculature and Right Heart.
Fawaz Alenezi, Taylor A Covington, Monica Mukherjee, Stephen C Mathai, Paul B Yu

Circ Res· April 2022

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Fibrodysplasia Ossificans Progressiva: What Have We Achieved and Where Are We Now? Follow-up to the 2015 Lorentz Workshop.
Ruben D de Ruiter, Bernard J Smilde, Gerard Pals, Nathalie Bravenboer, Petra Knaus, Paul B Yu

Front Endocrinol (Lausanne)· February 2022

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A New Link in the Chain: Unspliced XBP1 in Wnt Signaling and Vascular Calcification.
Peiran Yang, Paul B Yu

Circ Res· January 2022

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Generation of an induced pluripotent stem cell line (TRNDi012-B) from Fibrodysplasia Ossificans Progressiva (FOP) patient carrying a heterozygous mutation c. 617G > A in the ACVR1 gene.
Xiuli Huang, Amanda Roeder, Rong Li, Jeanette Beers, Chengyu Liu, Paul B Yu

Stem Cell Res· July 2021

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Sotatercept for Pulmonary Arterial Hypertension.
Peiran Yang, Geoffrey A Bocobo, Paul B Yu

N Engl J Med· July 2021

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A self-amplifying loop of YAP and SHH drives formation and expansion of heterotopic ossification.
Qian Cong, Yuchen Liu, Taifeng Zhou, Yaxing Zhou, Ruoshi Xu, Paul B Yu

Sci Transl Med· June 2021

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Bone Morphogenetic Protein-2 Induces Non-Canonical Inflammatory and Oxidative Pathways in Human Retinal Endothelial Cells.
Mohamed Al-Shabrawey, Khaled Hussein, Fang Wang, Ming Wan, Khaled Elmasry, Paul B Yu

Front Immunol· May 2021

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Saracatinib is an efficacious clinical candidate for fibrodysplasia ossificans progressiva.
Eleanor Williams, Jana Bagarova, Georgina Kerr, Dong-Dong Xia, Elsie S Place, Yue Shen, Paul B Yu

JCI Insight· April 2021

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