Publications by authors named "Paul C Simpson"

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Ca increases cardiac muscle viscoelasticity independent of active force development.
Anthony J Baker, On Yeung Li, Filip Ježek, Paul C Simpson, Naomi C Chesler

Biophys J· August 2025

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Norepinephrine signals through astrocytes to modulate synapses.
Katheryn B Lefton, Yifan Wu, Yanchao Dai, Takao Okuda, Yufen Zhang, Paul C Simpson

Science· May 2025

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Ca increases cardiac muscle viscoelasticity independent of active force development.
Anthony J Baker, On Yeung Li, Filip Ježek, Paul C Simpson, Naomi C Chesler

bioRxiv· February 2025

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Cortical norepinephrine-astrocyte signaling critically mediates learned behavior.
Gabrielle T Drummond, Arundhati Natesan, Marco Celotto, Jennifer Shih, Prachi Ojha, Paul C Simpson

bioRxiv· October 2024

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Norepinephrine Signals Through Astrocytes To Modulate Synapses.
Katheryn B Lefton, Yifan Wu, Allen Yen, Takao Okuda, Yufen Zhang, Paul C Simpson

bioRxiv· May 2024

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The alpha-1A adrenergic receptor regulates mitochondrial oxidative metabolism in the mouse heart.
Peyton B Sandroni, Melissa A Schroder, Hunter T Hawkins, Julian D Bailon, Wei Huang, Paul C Simpson

J Mol Cell Cardiol· February 2024

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Cardiomyocyte Alpha-1A Adrenergic Receptors Mitigate Postinfarct Remodeling and Mortality by Constraining Necroptosis.
Jiandong Zhang, Peyton B Sandroni, Wei Huang, Xiaohua Gao, Leah Oswalt, Paul C Simpson

JACC Basic Transl Sci· January 2024

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Norepinephrine links astrocytic activity to regulation of cortical state.
Michael E Reitman, Vincent Tse, Xuelong Mi, Drew D Willoughby, Alba Peinado, Paul C Simpson

Nat Neurosci· April 2023

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Cardiac α1A-adrenergic receptors: emerging protective roles in cardiovascular diseases.
Jiandong Zhang, Paul C Simpson, Brian C Jensen

Am J Physiol Heart Circ Physiol· February 2021

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Coupling to Gq Signaling Is Required for Cardioprotection by an Alpha-1A-Adrenergic Receptor Agonist.
Bat-Erdene Myagmar, Taylor Ismaili, Philip M Swigart, Anaha Raghunathan, Anthony J Baker, Paul C Simpson

Circ Res· September 2019

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Reversal of right ventricular failure by chronic α-subtype adrenergic agonist therapy.
Patrick M Cowley, Guanying Wang, Philip M Swigart, Anaha Raghunathan, Nikitha Reddy, Paul C Simpson

Am J Physiol Heart Circ Physiol· January 2019

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α-Subtype adrenergic agonist therapy for the failing right ventricle.
Patrick M Cowley, Guanying Wang, Sunil Joshi, Philip M Swigart, David H Lovett, Paul C Simpson

Am J Physiol Heart Circ Physiol· December 2017

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Shift toward greater pathologic post-myocardial infarction remodeling with loss of the adaptive hypertrophic signaling of alpha1 adrenergic receptors in mice.
Che-Chung Yeh, Yanying Fan, Yanchun Xu, Yi-Lin Yang, Paul C Simpson

PLoS One· December 2017

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A method to increase reproducibility in adult ventricular myocyte sizing and flow cytometry: Avoiding cell size bias in single cell preparations.
Javier E López, Katrin Jaradeh, Emmanuel Silva, Shadi Aminololama-Shakeri, Paul C Simpson

PLoS One· November 2017

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Novel large-particle FACS purification of adult ventricular myocytes reveals accumulation of myosin and actin disproportionate to cell size and proteome in normal post-weaning development.
Javier E López, Janhavi Sharma, Jorge Avila, Taylor S Wood, Jonathan E VanDyke, Paul C Simpson

J Mol Cell Cardiol· October 2017

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An Alpha-1A Adrenergic Receptor Agonist Prevents Acute Doxorubicin Cardiomyopathy in Male Mice.
Megan D Montgomery, Trevor Chan, Philip M Swigart, Bat-Erdene Myagmar, Rajesh Dash, Paul C Simpson

PLoS One· August 2017

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The Alpha-1A Adrenergic Receptor in the Rabbit Heart.
R Croft Thomas, Patrick M Cowley, Abhishek Singh, Bat-Erdene Myagmar, Philip M Swigart, Paul C Simpson

PLoS One· July 2017

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Response by Simpson et al to Letter Regarding Article, "Adrenergic Receptors in Individual Ventricular Myocytes: the Beta-1 and Alpha-1B Are in All Cells, the Alpha-1A Is in a Subpopulation, and the Beta-2 and Beta-3 Are Mostly Absent".
Paul C Simpson, Bat-Erdene Myagmar, Philip M Swigart, Simon Melov, Anthony J Baker

Circ Res· June 2017

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Adrenergic Receptors in Individual Ventricular Myocytes: The Beta-1 and Alpha-1B Are in All Cells, the Alpha-1A Is in a Subpopulation, and the Beta-2 and Beta-3 Are Mostly Absent.
Bat-Erdene Myagmar, James M Flynn, Patrick M Cowley, Philip M Swigart, Megan D Montgomery, Paul C Simpson

Circ Res· March 2017

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An Oral Selective Alpha-1A Adrenergic Receptor Agonist Prevents Doxorubicin Cardiotoxicity.
JuYoun Beak, Wei Huang, Joel S Parker, Sean T Hicks, Cam Patterson, Paul C Simpson

JACC Basic Transl Sci· February 2017

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The alpha-1A adrenergic receptor agonist A61603 reduces cardiac polyunsaturated fatty acid and endocannabinoid metabolites associated with inflammation in vivo.
Monte S Willis, Amro Ilaiwy, Megan D Montgomery, Paul C Simpson, Brian C Jensen

Metabolomics· October 2016

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A Myocardial Slice Culture Model Reveals Alpha-1A-Adrenergic Receptor Signaling in the Human Heart.
R Croft Thomas, Abhishek Singh, Patrick Cowley, Bat-Erdene Myagmar, Megan D Montgomery, Paul C Simpson

JACC Basic Transl Sci· April 2016

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The α1A-adrenergic receptor subtype mediates increased contraction of failing right ventricular myocardium.
Patrick M Cowley, Guanying Wang, Audrey N Chang, Om Makwana, Philip M Swigart, Paul C Simpson

Am J Physiol Heart Circ Physiol· September 2015

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A New Pathway for Sympathetic Cardioprotection in Heart Failure.
Paul C Simpson

Circ Res· September 2015

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Myofilament dysfunction contributes to impaired myocardial contraction in the infarct border zone.
Rafael Shimkunas, Om Makwana, Kimberly Spaulding, Mona Bazargan, Michael Khazalpour, Paul C Simpson

Am J Physiol Heart Circ Physiol· October 2014

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