Publications by authors named "Paul Chapple"

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J-domain proteins: from molecular mechanisms to diseases.
Janine Kirstein, Rina Rosenzweig, Paolo De Los Rios, Pierre Genevaux, Charlotte Adang, J Paul Chapple

Cell Stress Chaperones· December 2025

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A new ANMerge-based blood transcriptomic resource to support Alzheimer's disease research.
Nasim Mohamed Ismail, Maggie Miller, Hannah Crossland, Jalil-Ahmad Sharif, J Paul Chapple

medRxiv· October 2025

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Experimental menopause in 3xTg-AD mice exacerbates metabolic, inflammatory, and osteologic phenotypes aligned with Alzheimer's disease pathology.
Jessica L Dennison, Maggie A Miller, Aikta Sharma, Ava M Cherry, Irina Djuraskovic, J Paul Chapple

Res Sq· October 2025

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CRISPRa-Mediated Increase of OPA1 Expression in Dominant Optic Atrophy.
Giada Becchi, Michael Whitehead, Joshua P Harvey, Paul E Sladen, Mohammed Dushti, J Paul Chapple

Int J Mol Sci· July 2025

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Altered Cellular Metabolism Is a Consequence of Loss of the Ataxia-Linked Protein Sacsin.
Laura Perna, Grace Salsbury, Mohammed Dushti, Christopher J Smith, Valle Morales, J Paul Chapple

Int J Mol Sci· December 2024

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Network-based modelling reveals cell-type enriched patterns of non-coding RNA regulation during human skeletal muscle remodelling.
Jonathan C Mcleod, Changhyun Lim, Tanner Stokes, Jalil-Ahmad Sharif, Vagif Zeynalli, J Paul Chapple

bioRxiv· October 2024

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Network-based modelling reveals cell-type enriched patterns of non-coding RNA regulation during human skeletal muscle remodelling.
Jonathan C Mcleod, Changhyun Lim, Tanner Stokes, Jalil-Ahmad Sharif, Vagif Zeynalli, J Paul Chapple

NAR Mol Med· October 2024

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J-domain proteins: From molecular mechanisms to diseases.
Jaroslaw Marszalek, Paolo De Los Rios, Douglas Cyr, Matthias P Mayer, Vasista Adupa, J Paul Chapple

Cell Stress Chaperones· February 2024

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A Digital Health Solution for Child Growth Monitoring at Home: Testing the Accuracy of a Novel "GrowthMonitor" Smartphone Application to Detect Abnormal Height and Body Mass Indices.
Thilipan Thaventhiran, Joanna Orr, Joan K Morris, Anne Hsu, Lee Martin, Paul Chapple

Mayo Clin Proc Digit Health· December 2023

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Generation of glucocorticoid-producing cells derived from human pluripotent stem cells.
Gerard Ruiz-Babot, Ariane Eceiza, Fernando Abollo-Jiménez, Maria Malyukov, Diana L Carlone, Paul J Chapple

Cell Rep Methods· November 2023

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First-in-human in-vivo depiction of paraganglioma metabolism by hyperpolarised C-magnetic resonance.
Rafat Chowdhury, Myuri Moorthy, Lorna Smith, Christoph A Mueller, Fiona Gong, Paul Chapple

BJR Case Rep· November 2023

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AlphaFold predicted structure of the Hsp90-like domains of the neurodegeneration linked protein sacsin reveals key residues for ATPase activity.
Laura Perna, Matteo Castelli, Elena Frasnetti, Lisa E L Romano, Giorgio Colombo, J Paul Chapple

Front Mol Biosci· January 2023

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HSP70-HSP90 Chaperone Networking in Protein-Misfolding Disease.
Chrisostomos Prodromou, Xavi Aran-Guiu, Jasmeen Oberoi, Laura Perna, J Paul Chapple

Subcell Biochem· December 2022

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Multi-omic profiling reveals the ataxia protein sacsin is required for integrin trafficking and synaptic organization.
Lisa E L Romano, Wen Yih Aw, Kathryn M Hixson, Tatiana V Novoselova, Tammy M Havener, J Paul Chapple

Cell Rep· November 2022

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Modelling autosomal dominant optic atrophy associated with OPA1 variants in iPSC-derived retinal ganglion cells.
Paul E Sladen, Katarina Jovanovic, Rosellina Guarascio, Daniele Ottaviani, Grace Salsbury, J Paul Chapple

Hum Mol Genet· October 2022

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Antiproliferative effects of metformin in cellular models of pheochromocytoma.
Cinthia Gabriel Meireles, Caroline Lourenço de Lima, Marcela Martins de Paula Oliveira, Rafael Abe da Rocha Miranda, Lisa Romano, J Paul Chapple

Mol Cell Endocrinol· January 2022

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CRISPR-Cas9 correction of c.1334G>A: p.R445H restores mitochondrial homeostasis in dominant optic atrophy patient-derived iPSCs.
Paul E Sladen, Pedro R L Perdigão, Grace Salsbury, Tatiana Novoselova, Jacqueline van der Spuy, J Paul Chapple

Mol Ther Nucleic Acids· December 2021

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GATA3 induces mitochondrial biogenesis in primary human CD4 T cells during DNA damage.
Lauren A Callender, Johannes Schroth, Elizabeth C Carroll, Conor Garrod-Ketchley, Lisa E L Romano, J Paul Chapple

Nat Commun· June 2021

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Polycystin-2 Is Required for Chondrocyte Mechanotransduction and Traffics to the Primary Cilium in Response to Mechanical Stimulation.
Clare L Thompson, Megan McFie, J Paul Chapple, Philip Beales, Martin M Knight

Int J Mol Sci· April 2021

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Mitochondria form contact sites with the nucleus to couple prosurvival retrograde response.
Radha Desai, Daniel A East, Liana Hardy, Danilo Faccenda, Manuel Rigon, J Paul Chapple

Sci Adv· December 2020

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Corrigendum to: The co-chaperone and reductase ERdj5 facilitates rod opsin biogenesis and quality control.
Dimitra Athanasiou, Dalila Bevilacqua, Monica Aguila, Caroline McCulley, Naheed Kanuga, J Paul Chapple

Hum Mol Genet· November 2020

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Oncometabolite induced primary cilia loss in pheochromocytoma.
Samuel M O'Toole, David S Watson, Tatiana V Novoselova, Lisa E L Romano, Peter J King, J Paul Chapple

Endocr Relat Cancer· January 2019

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Optical coherence tomography in autosomal recessive spastic ataxia of Charlevoix-Saguenay.
Michael H Parkinson, Ana P Bartmann, Lisa M S Clayton, Suran Nethisinghe, Rolph Pfundt, J Paul Chapple

Brain· April 2018

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Arl3 and RP2 regulate the trafficking of ciliary tip kinesins.
Nele Schwarz, Amelia Lane, Katarina Jovanovic, David A Parfitt, Monica Aguila, J Paul Chapple

Hum Mol Genet· September 2017

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Altered organization of the intermediate filament cytoskeleton and relocalization of proteostasis modulators in cells lacking the ataxia protein sacsin.
Emma J Duncan, Roxanne Larivière, Teisha Y Bradshaw, Fabiana Longo, Nicolas Sgarioto, J Paul Chapple

Hum Mol Genet· August 2017

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