Publications by authors named "Paul D van Helden"

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The Indian Ocean slave trade and colonial expansion resulted in strong sex-biased admixture in South Africa.
Austin W Reynolds, Haiko Schurz, Gillian Meeks, Simon Gravel, Justin W Myrick, Paul D van Helden

Am J Hum Genet· October 2025

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Baseline and end-of-treatment host serum biomarkers predict relapse in adults with pulmonary tuberculosis.
Hygon Mutavhatsindi, Charles M Manyelo, Candice I Snyders, Ilana Van Rensburg, Martin Kidd, Paul D van Helden

J Infect· July 2024

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Point-of-care C-reactive protein and Xpert MTB/RIF Ultra for tuberculosis screening and diagnosis in unselected antiretroviral therapy initiators: a prospective, cross-sectional, diagnostic accuracy study.
Byron W P Reeve, Gcobisa Ndlangalavu, Hridesh Mishra, Zaida Palmer, Happy Tshivhula, Paul D van Helden

Lancet Glob Health· May 2024

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Whole genome sequencing improves the discrimination between strains on the southern border of Kruger National Park, South Africa.
Eduard O Roos, Johannes Loubser, Tanya J Kerr, Anzaan Dippenaar, Elizma Streicher, Paul D van Helden

One Health· December 2023

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"Spotting" infection in leopards () - novel application of diagnostic tools.
Rachiel Gumbo, Wynand J Goosen, Peter E Buss, Lin-Mari de Klerk-Lorist, Konstantin Lyashchenko, Paul D van Helden

Front Immunol· September 2023

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Point-of-care C-reactive protein and Xpert MTB/RIF Ultra for tuberculosis screening and diagnosis in unselected antiretroviral therapy initiators: a prospective diagnostic accuracy study.
Byron Wp Reeve, Gcobisa Ndlangalavu, Hridesh Mishra, Zaida Palmer, Happy Tshivhula, Paul D van Helden

medRxiv· June 2023

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Comparison of interferon gamma release assay and gene expression assay for the detection of infection in African lions ().
Rachiel Gumbo, Tashnica T Sylvester, Sven D C Parsons, Peter E Buss, Robin M Warren, Paul D van Helden

Front Cell Infect Microbiol· October 2022

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Adaptation and Diagnostic Potential of a Commercial Cat Interferon Gamma Release Assay for the Detection of Infection in African Lions ().
Rachiel Gumbo, Tashnica T Sylvester, Wynand J Goosen, Peter E Buss, Lin-Mari de Klerk-Lorist, Paul D van Helden

Pathogens· July 2022

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Diagnosis of Mycobacterium bovis infection in free-ranging common hippopotamus (Hippopotamus amphibius).
Tanya J Kerr, Wynand J Goosen, Rachiel Gumbo, Lin-Mari de Klerk-Lorist, Oonagh Pretorius, Paul D van Helden

Transbound Emerg Dis· March 2022

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Deciphering Genetic Susceptibility to Tuberculous Meningitis.
Haiko Schurz, Brigitte Glanzmann, Nicholas Bowker, Ronald van Toorn, Regan Solomons, Paul D van Helden

Front Neurol· March 2022

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Improved detection of and in African wildlife samples using cationic peptide decontamination and mycobacterial culture supplementation.
Wynand J Goosen, Léanie Kleynhans, Tanya J Kerr, Paul D van Helden, Peter Buss

J Vet Diagn Invest· January 2022

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CYTOKINE-RELEASE ASSAY FOR THE DETECTION OF INFECTION IN CHEETAH ().
Rachiel Gumbo, Elin Crockett, Wynand J Goosen, Robin M Warren, Paul D van Helden

J Zoo Wildl Med· December 2021

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Complex evolutionary history of felid anelloviruses.
Simona Kraberger, Laurel Ek Serieys, Cécile Richet, Nicholas M Fountain-Jones, Guy Baele, Paul D van Helden

Virology· October 2021

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Local Ancestry Adjusted Allelic Association Analysis Robustly Captures Tuberculosis Susceptibility Loci.
Yolandi Swart, Caitlin Uren, Paul D van Helden, Eileen G Hoal, Marlo Möller

Front Genet· October 2021

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Diagnostic accuracy of the FluoroType MTB and MTBDR VER 2.0 assays for the centralized high-throughput detection of Mycobacterium tuberculosis complex DNA and isoniazid and rifampicin resistance.
Anzaan Dippenaar, Brigitta Derendinger, Tania Dolby, Natalie Beylis, Paul D van Helden

Clin Microbiol Infect· September 2021

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1,3-Diarylpyrazolyl-acylsulfonamides as Potent Anti-tuberculosis Agents Targeting Cell Wall Biosynthesis in .
Lutete Peguy Khonde, Rudolf Müller, Grant A Boyle, Virsinha Reddy, Aloysius T Nchinda, Paul D van Helden

J Med Chem· September 2021

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A multi-phenotype genome-wide association study of clades causing tuberculosis in a Ghanaian- and South African cohort.
Stephanie J Müller, Haiko Schurz, Gerard Tromp, Gian D van der Spuy, Eileen G Hoal, Paul D van Helden

Genomics· July 2021

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Shedding of Mycobacterium bovis in respiratory secretions of free-ranging wild dogs (Lycaon pictus): Implications for intraspecies transmission.
Christina Meiring, Roxanne Higgitt, Wynand J Goosen, Louis van Schalkwyk, Lin-Mari de Klerk-Lorist, Paul D van Helden

Transbound Emerg Dis· July 2021

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Development of a cytokine gene expression assay for the relative quantification of the African elephant (Loxodonta africana) cell-mediated immune responses.
Candice R de Waal, Léanie Kleynhans, Sven D C Parsons, Wynand J Goosen, Guy Hausler, Paul D van Helden

Cytokine· May 2021

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Anaerobe-enriched gut microbiota predicts pro-inflammatory responses in pulmonary tuberculosis.
Charissa C Naidoo, Georgina R Nyawo, Imran Sulaiman, Benjamin G Wu, Carolin T Turner, Paul D van Helden

EBioMedicine· May 2021

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Novel molecular transport medium used in combination with Xpert MTB/RIF ultra provides rapid detection of Mycobacterium bovis in African buffaloes.
Charlene Clarke, Katrin Smith, Samantha J Goldswain, Christopher Helm, David V Cooper, Paul D van Helden

Sci Rep· March 2021

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Cytokine biomarker discovery in the white rhinoceros (Ceratotherium simum).
Josephine Chileshe, Tanya J Kerr, Craig Kinnear, Peter E Buss, Paul D van Helden

Vet Immunol Immunopathol· February 2021

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Antitubercular 2-Pyrazolylpyrimidinones: Structure-Activity Relationship and Mode-of-Action Studies.
Candice Soares de Melo, Vinayak Singh, Alissa Myrick, Sandile B Simelane, Dale Taylor, Paul D van Helden

J Med Chem· January 2021

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Review of Diagnostic Tests for Detection of Infection in South African Wildlife.
Netanya Bernitz, Tanya J Kerr, Wynand J Goosen, Josephine Chileshe, Roxanne L Higgitt, Paul D van Helden

Front Vet Sci· January 2021

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The Xpert MTB/RIF Ultra assay detects Mycobacterium tuberculosis complex DNA in white rhinoceros (Ceratotherium simum) and African elephants (Loxodonta africana).
Wynand J Goosen, Tanya J Kerr, Léanie Kleynhans, Robin M Warren, Paul D van Helden

Sci Rep· September 2020

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