Publications by authors named "Paul Fitzpatrick"

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Conservation of mechanism in flavoprotein-catalyzed amine oxidation.
Paul F Fitzpatrick

Arch Biochem Biophys· February 2025

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A novel in vitro high-content imaging assay for the prediction of drug-induced lung toxicity.
Paul A Fitzpatrick, Julia Johansson, Gareth Maglennon, Ian Wallace, Ramon Hendrickx

Arch Toxicol· September 2024

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Biochemical and biophysical approaches to characterization of the aromatic amino acid hydroxylases.
Paul F Fitzpatrick, S Colette Daubner

Methods Enzymol· September 2024

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Mechanistic safety assessment via multi-omic characterisation of systemic pathway perturbations following in vivo MAT2A inhibition.
Valentina Fogal, Filippos Michopoulos, Andrew F Jarnuczak, Ghaith M Hamza, Stephanie Harlfinger, Paul Fitzpatrick

Arch Toxicol· August 2024

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The aromatic amino acid hydroxylases: Structures, catalysis, and regulation of phenylalanine hydroxylase, tyrosine hydroxylase, and tryptophan hydroxylase.
Paul F Fitzpatrick

Arch Biochem Biophys· February 2023

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Thermodynamics of iron, tetrahydrobiopterin, and phenylalanine binding to phenylalanine hydroxylase from Chromobacterium violaceum.
Mingjie Li, Bishnu P Subedi, Paul F Fitzpatrick, Joseph P Emerson

Arch Biochem Biophys· October 2022

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Archives of Biochemistry and Biophysics: 80th Anniversary.
Helmut Sies, Paul F Fitzpatrick, Anthony Newman, Henry Jay Forman

Arch Biochem Biophys· September 2022

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An International Comparison of Presentation, Outcomes and CORONET Predictive Score Performance in Patients with Cancer Presenting with COVID-19 across Different Pandemic Waves.
Oskar Wysocki, Cong Zhou, Jacobo Rogado, Prerana Huddar, Rohan Shotton, Paul Fitzpatrick

Cancers (Basel)· August 2022

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Establishment of CORONET, COVID-19 Risk in Oncology Evaluation Tool, to Identify Patients With Cancer at Low Versus High Risk of Severe Complications of COVID-19 Disease On Presentation to Hospital.
Rebecca J Lee, Oskar Wysocki, Cong Zhou, Rohan Shotton, Ann Tivey, Paul Fitzpatrick

JCO Clin Cancer Inform· May 2022

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Pharmacological inhibition of MERTK induces in vivo retinal degeneration: a multimodal imaging ocular safety assessment.
Gregory Hamm, Gareth Maglennon, Beth Williamson, Ruth Macdonald, Ann Doherty, Paul Fitzpatrick

Arch Toxicol· February 2022

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Biomarker identification using dynamic time warping analysis: a longitudinal cohort study of patients with COVID-19 in a UK tertiary hospital.
Hannah Burke, Anna Freeman, Paul O'Regan, Oskar Wysocki, Andre Freitas, Paul Fitzpatrick

BMJ Open· February 2022

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Wave comparisons of clinical characteristics and outcomes of COVID-19 admissions - Exploring the impact of treatment and strain dynamics.
Anna Freeman, Alastair Watson, Paul O'Regan, Oskar Wysocki, Hannah Burke, Paul Fitzpatrick

J Clin Virol· January 2022

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Patient-derived scaffolds influence secretion profiles in cancer cells mirroring clinical features and breast cancer subtypes.
Emma Persson, Pernilla Gregersson, Anna Gustafsson, Paul Fitzpatrick, Sara Rhost

Cell Commun Signal· June 2021

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Research Evaluation Alongside Clinical Treatment in COVID-19 (REACT COVID-19): an observational and biobanking study.
Hannah Burke, Anna Freeman, Ahilanandan Dushianthan, Michael Celinski, James Batchelor, Paul Fitzpatrick

BMJ Open· January 2021

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Biosimilar infliximab administration for the management of acute graft-versus-host disease.
Eris Tollkuci, Paul Fitzpatrick, Amanda N Seddon, Rebecca Myers, Sunita Nathan

J Oncol Pharm Pract· December 2020

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Characterization of cell-free breast cancer patient-derived scaffolds using liquid chromatography-mass spectrometry/mass spectrometry data and RNA sequencing data.
Göran Landberg, Emma Jonasson, Anna Gustafsson, Paul Fitzpatrick, Pauline Isakson

Data Brief· August 2020

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ICU Patient Family Stress Recovery During Breaks in a Hospital Garden and Indoor Environments.
Roger S Ulrich, Makayla Cordoza, Stuart K Gardiner, Bette J Manulik, Paul S Fitzpatrick

HERD· April 2020

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Translational studies of intravenous and intracerebroventricular routes of administration for CNS cellular biodistribution for BMN 250, an enzyme replacement therapy for the treatment of Sanfilippo type B.
Anita Grover, Danielle Crippen-Harmon, Lacey Nave, Jon Vincelette, Jill C M Wait, Paul A Fitzpatrick

Drug Deliv Transl Res· April 2020

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Patient-derived scaffolds uncover breast cancer promoting properties of the microenvironment.
Göran Landberg, Paul Fitzpatrick, Pauline Isakson, Emma Jonasson, Joakim Karlsson

Biomaterials· March 2020

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pH and deuterium isotope effects on the reaction of trimethylamine dehydrogenase with dimethylamine.
Udayanga S Wanninayake, Bishnu Subedi, Paul F Fitzpatrick

Arch Biochem Biophys· November 2019

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Hypoxia-induced secretion stimulates breast cancer stem cell regulatory signalling pathways.
Hanna Jacobsson, Hannah Harrison, Éamon Hughes, Emma Persson, Sara Rhost, Paul Fitzpatrick

Mol Oncol· August 2019

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New Benzopyranyl Cadenane Sesquiterpene and Other Antiplasmodial and Cytotoxic Metabolites from .
Stephen S Nyandoro, Gasper Maeda, Joan J E Munissi, Amra Gruhonjic, Paul A Fitzpatrick

Molecules· July 2019

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Mechanism of the Flavoprotein d-6-Hydroxynicotine Oxidase: Substrate Specificity, pH and Solvent Isotope Effects, and Roles of Key Active-Site Residues.
Paul F Fitzpatrick, Vi Dougherty, Bishnu Subedi, Jesus Quilantan, Cynthia S Hinck

Biochemistry· May 2019

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The phenylketonuria-associated substitution R68S converts phenylalanine hydroxylase to a constitutively active enzyme but reduces its stability.
Crystal A Khan, Steve P Meisburger, Nozomi Ando, Paul F Fitzpatrick

J Biol Chem· March 2019

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Sortilin inhibition limits secretion-induced progranulin-dependent breast cancer progression and cancer stem cell expansion.
Sara Rhost, Éamon Hughes, Hannah Harrison, Svanheidur Rafnsdottir, Hanna Jacobsson, Paul Fitzpatrick

Breast Cancer Res· November 2018

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