Publications by authors named "Paul Lehner"

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Reduced Cas9 transgene silencing by incorporation of intron sequences.
Sophia Arana, Peter P Du, Alun Vaughan-Jackson, Nora Enright, Kaitlyn Spees, Paul J Lehner

Nat Commun· November 2025

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Virion proteomics of genetically intact HCMV reveals a regulator of envelope glycoprotein composition that protects against humoral immunity.
Kirsten Bentley, Evelina Statkute, Isa Murrell, Ceri A Fielding, Robin Antrobus, Paul J Lehner

Proc Natl Acad Sci U S A· September 2025

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Silencing by the HUSH Epigenetic Transcriptional Repressor Complex.
Paul J Lehner

Annu Rev Biochem· June 2025

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CRISPR-Cas9 genetic screens reveal regulation of TMPRSS2 by the Elongin BC-VHL complex.
Ildar Gabaev, Alexandra Rowland, Emilija Jovanovic, Christian M Gawden-Bone, Thomas W M Crozier, Paul J Lehner

Sci Rep· April 2025

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A novel human fetal lung-derived alveolar organoid model reveals mechanisms of surfactant protein C maturation relevant to interstitial lung disease.
Kyungtae Lim, Eimear N Rutherford, Livia Delpiano, Peng He, Weimin Lin, Paul J Lehner

EMBO J· February 2025

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RNA binding by Periphilin plays an essential role in initiating silencing by the HUSH complex.
Stuart Bloor, Niek Wit, Paul J Lehner

Nucleic Acids Res· January 2025

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The HUSH epigenetic repressor complex silences PML nuclear body-associated HSV-1 quiescent genomes.
Simon Roubille, Tristan Escure, Franceline Juillard, Armelle Corpet, Rémi Néplaz, Paul J Lehner

Proc Natl Acad Sci U S A· December 2024

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Author Correction: A HIF independent oxygen-sensitive pathway for controlling cholesterol synthesis.
Anna S Dickson, Tekle Pauzaite, Esther Arnaiz, Brian M Ortmann, James A West, Paul J Lehner

Nat Commun· March 2024

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Spontaneous, persistent, T cell-dependent IFN-γ release in patients who progress to Long Covid.
Benjamin A Krishna, Eleanor Y Lim, Marina Metaxaki, Sarah Jackson, Lenette Mactavous, Paul J Lehner

Sci Adv· February 2024

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As a matter of fat: Emerging roles of lipid-sensitive E3 ubiquitin ligases.
Christian M Gawden-Bone, Paul J Lehner, Norbert Volkmar

Bioessays· December 2023

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MORC3 represses the HCMV major immediate early promoter in myeloid cells in the absence of PML nuclear bodies.
Anna Champion, Alexandra Rowland, Levia Yee, Dick van den Boomen, Matthew Reeves, Paul Lehner

J Med Virol· November 2023

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Author Correction: A HIF independent oxygen-sensitive pathway for controlling cholesterol synthesis.
Anna S Dickson, Tekle Pauzaite, Esther Arnaiz, Brian M Ortmann, James A West, Paul J Lehner

Nat Commun· November 2023

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A novel human fetal lung-derived alveolar organoid model reveals mechanisms of surfactant protein C maturation relevant to interstitial lung disease.
Kyungtae Lim, Eimear N Rutherford, Dawei Sun, Dick J H Van den Boomen, James R Edgar, Paul J Lehner

bioRxiv· September 2023

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A HIF independent oxygen-sensitive pathway for controlling cholesterol synthesis.
Anna S Dickson, Tekle Pauzaite, Esther Arnaiz, Brian M Ortmann, James A West, Paul J Lehner

Nat Commun· August 2023

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Proteomic analysis of circulating immune cells identifies cellular phenotypes associated with COVID-19 severity.
Martin Potts, Alice Fletcher-Etherington, Katie Nightingale, Federica Mescia, Laura Bergamaschi, Paul J Lehner

Cell Rep· June 2023

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The sound of silence: mechanisms and implications of HUSH complex function.
Marta Seczynska, Paul J Lehner

Trends Genet· April 2023

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Altered plasma membrane abundance of the sulfatide-binding protein NF155 links glycosphingolipid imbalances to demyelination.
Shannon J McKie, Alex S Nicholson, Emily Smith, Stuart Fawke, Eve R Caroe, Paul J Lehner

Proc Natl Acad Sci U S A· April 2023

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Cigarette smoke preferentially induces full length ACE2 expression in differentiated primary human airway cultures but does not alter the efficiency of cellular SARS-CoV-2 infection.
Linsey M Porter, Wenrui Guo, Thomas Wm Crozier, Edward Jd Greenwood, Brian Ortmann, Paul J Lehner

Heliyon· March 2023

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Human Cytomegalovirus Infection of Epithelial Cells Increases SARS-CoV-2 Superinfection by Upregulating the ACE2 Receptor.
Marianne R Perera, Edward J D Greenwood, Thomas W M Crozier, Elizabeth G Elder, Janika Schmitt, Paul J Lehner

J Infect Dis· February 2023

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Targeting Menin disrupts the KMT2A/B and polycomb balance to paradoxically activate bivalent genes.
Christina E Sparbier, Andrea Gillespie, Juliana Gomez, Nishi Kumari, Ali Motazedian, Paul J Lehner

Nat Cell Biol· February 2023

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LRRC15 mediates an accessory interaction with the SARS-CoV-2 spike protein.
Jarrod Shilts, Thomas W M Crozier, Ana Teixeira-Silva, Ildar Gabaev, Pehuén Pereyra Gerber, Paul J Lehner

PLoS Biol· February 2023

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EROS is a selective chaperone regulating the phagocyte NADPH oxidase and purinergic signalling.
Lyra O Randzavola, Paige M Mortimer, Emma Garside, Elizabeth R Dufficy, Andrea Schejtman, Paul J Lehner

Elife· November 2022

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Regulation of membrane fluidity by RNF145-triggered degradation of the lipid hydrolase ADIPOR2.
Norbert Volkmar, Christian M Gawden-Bone, James C Williamson, Jonathon Nixon-Abell, James A West, Paul J Lehner

EMBO J· October 2022

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Quantitative proteomic analysis of SARS-CoV-2 infection of primary human airway ciliated cells and lung epithelial cells demonstrates the effectiveness of SARS-CoV-2 innate immune evasion.
Thomas W M Crozier, Edward J D Greenwood, James C Williamson, Wenrui Guo, Linsey M Porter, Paul J Lehner

Wellcome Open Res· September 2022

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Evidence of previous SARS-CoV-2 infection in seronegative patients with long COVID.
Benjamin A Krishna, Eleanor Y Lim, Lenette Mactavous, , Paul A Lyons, Paul J Lehner

EBioMedicine· July 2022

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