Publications by authors named "Paul M Steed"

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Discovery of novel aminoquinazolin-7-yl 6,7-dihydro-indol-4-ones as potent, selective inhibitors of heat shock protein 90.
Kenneth H Huang, Thomas E Barta, John W Rice, Emilie D Smith, Andy J Ommen, Paul M Steed

Bioorg Med Chem Lett· April 2012

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Application of chemoproteomics to drug discovery: identification of a clinical candidate targeting hsp90.
Patrick Fadden, Kenneth H Huang, James M Veal, Paul M Steed, Amy F Barabasz

Chem Biol· July 2010

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Brain-permeable small-molecule inhibitors of Hsp90 prevent alpha-synuclein oligomer formation and rescue alpha-synuclein-induced toxicity.
Preeti Putcha, Karin M Danzer, Lisa R Kranich, Anisa Scott, Melanie Silinski, Paul M Steed

J Pharmacol Exp Ther· March 2010

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Discovery of novel 2-aminobenzamide inhibitors of heat shock protein 90 as potent, selective and orally active antitumor agents.
Kenneth H Huang, James M Veal, R Patrick Fadden, John W Rice, Jeron Eaves, Paul M Steed

J Med Chem· July 2009

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Small molecule inhibitors of Hsp90 potently affect inflammatory disease pathways and exhibit activity in models of rheumatoid arthritis.
John W Rice, James M Veal, R Patrick Fadden, Amy F Barabasz, Jeffrey M Partridge, Paul M Steed

Arthritis Rheum· December 2008

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Dominant-negative inhibitors of soluble TNF attenuate experimental arthritis without suppressing innate immunity to infection.
Jonathan Zalevsky, Thomas Secher, Sergei A Ezhevsky, Laure Janot, Paul M Steed

J Immunol· August 2007

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Discovery of highly selective inhibitors of p38alpha.
Ioana Popa-Burke, Steve Birkos, Leonard Blackwell, Lynn Cheatham, Jennifer Clark, Paul M Steed

Curr Top Med Chem· January 2006

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Inactivation of TNF signaling by rationally designed dominant-negative TNF variants.
Paul M Steed, Malú G Tansey, Jonathan Zalevsky, Eugene A Zhukovsky, John R Desjarlais

Science· September 2003

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The TNF superfamily is on the TRAIL to BlyS.
Paul M Steed, René S Hubert

Drug Discov Today· February 2003

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Presence of cathepsin B in the human pancreatic secretory pathway and its role in trypsinogen activation during hereditary pancreatitis.
Zoltán Kukor, Julia Mayerle, Burkhard Krüger, Miklós Tóth, Paul M Steed

J Biol Chem· June 2002

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