Publications by authors named "Paul Needs"

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Aerobic in vitro studies of spontaneous anthocyanin degradation are not useful models for anthocyanin breakdown in the human colon.
Emad Shehata, Jasmine Percival, Mark Philo, Paul W Needs, Michael N Clifford

Food Chem· September 2025

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The 2-aminoethyl diphenylborinate-based fluorescent method identifies quercetin and luteolin metabolites as substrates of Organic anion transporting polypeptides, OATP1B1 and OATP2B1.
Hana Kaci, Éva Bakos, Paul W Needs, Paul A Kroon, Kateřina Valentová

Eur J Pharm Sci· May 2024

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Anti-Inflammatory Effects of Quercetin on High-Glucose and Pro-Inflammatory Cytokine Challenged Vascular Endothelial Cell Metabolism.
Besim Ozyel, Gwénaëlle Le Gall, Paul W Needs, Paul A Kroon

Mol Nutr Food Res· March 2021

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Polyphenols bind to low density lipoprotein at biologically relevant concentrations that are protective for heart disease.
Wei-Cheng Tung, Bryan Rizzo, Yusef Dabbagh, Suraj Saraswat, Mark Romanczyk, Paul W Needs

Arch Biochem Biophys· November 2020

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Citrus flavanone metabolites protect pancreatic-β cells under oxidative stress induced by cholesterol.
Sara L Anacleto, Dragan Milenkovic, Paul A Kroon, Paul W Needs, Franco Maria Lajolo

Food Funct· October 2020

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Inhibitory Effects of Quercetin and Its Main Methyl, Sulfate, and Glucuronic Acid Conjugates on Cytochrome P450 Enzymes, and on OATP, BCRP and MRP2 Transporters.
Violetta Mohos, Eszter Fliszár-Nyúl, Orsolya Ungvári, Katalin Kuffa, Paul W Needs

Nutrients· July 2020

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Monomeric Flavanols Are More Efficient Substrates for Gut Microbiota Conversion to Hydroxyphenyl-γ-Valerolactone Metabolites Than Oligomeric Procyanidins: A Randomized, Placebo-Controlled Human Intervention Trial.
Wendy J Hollands, Mark Philo, Natalia Perez-Moral, Paul W Needs, George M Savva

Mol Nutr Food Res· May 2020

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Quantitative Dietary Fingerprinting (QDF)-A Novel Tool for Comprehensive Dietary Assessment Based on Urinary Nutrimetabolomics.
Raúl González-Domínguez, Mireia Urpi-Sarda, Olga Jáuregui, Paul W Needs, Paul A Kroon

J Agric Food Chem· February 2020

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The Effects of Anthocyanins and Their Microbial Metabolites on the Expression and Enzyme Activities of Paraoxonase 1, an Important Marker of HDL Function.
Hassan T Aboufarrag, Paul W Needs, Gerald Rimbach, Paul A Kroon

Nutrients· November 2019

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Accumulation of Dietary S-Methyl Cysteine Sulfoxide in Human Prostate Tissue.
Jack Coode-Bate, Tharsini Sivapalan, Antonietta Melchini, Shikha Saha, Paul W Needs

Mol Nutr Food Res· October 2019

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Plant Bioactives and the Prevention of Prostate Cancer: Evidence from Human Studies.
Tracey L Livingstone, Gemma Beasy, Robert D Mills, Jenny Plumb, Paul W Needs

Nutrients· September 2019

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Correction: Different antitumor effects of quercetin, quercetin-3'-sulfate and quercetin-3-glucuronide in human breast cancer MCF-7 cells.
Qiu Wu, Paul W Needs, Yalong Lu, Paul A Kroon, Daoyuan Ren

Food Funct· July 2019

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An LC-MS/MS Method to Measure -Methyl-l-Cysteine and -Methyl-l-Cysteine Sulfoxide in Human Specimens Using Isotope Labelled Internal Standards.
Tharsini Sivapalan, Antonietta Melchini, Jack Coode-Bate, Paul W Needs, Richard F Mithen

Molecules· July 2019

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Hydrophobic Interactions Drive Binding between Vascular Endothelial Growth Factor-A (VEGFA) and Polyphenolic Inhibitors.
Natalia Perez-Moral, Paul W Needs, Christina W A Moyle, Paul A Kroon

Molecules· July 2019

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Inhibitory Effects of Quercetin and Its Human and Microbial Metabolites on Xanthine Oxidase Enzyme.
Violetta Mohos, Attila Pánovics, Eszter Fliszár-Nyúl, Gabriella Schilli, Csaba Hetényi, Paul W Needs

Int J Mol Sci· May 2019

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Transcriptional changes in prostate of men on active surveillance after a 12-mo glucoraphanin-rich broccoli intervention-results from the Effect of Sulforaphane on prostate CAncer PrEvention (ESCAPE) randomized controlled trial.
Maria H Traka, Antonietta Melchini, Jack Coode-Bate, Omar Al Kadhi, Shikha Saha, Paul W Needs

Am J Clin Nutr· April 2019

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Bioavailability of Glucoraphanin and Sulforaphane from High-Glucoraphanin Broccoli.
Tharsini Sivapalan, Antonietta Melchini, Shikha Saha, Paul W Needs, Maria H Traka

Mol Nutr Food Res· September 2018

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Differential Effects of Quercetin and Two of Its Derivatives, Isorhamnetin and Isorhamnetin-3-glucuronide, in Inhibiting the Proliferation of Human Breast-Cancer MCF-7 Cells.
Qiu Wu, Paul A Kroon, Hongjun Shao, Paul W Needs, Xingbin Yang

J Agric Food Chem· July 2018

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Different antitumor effects of quercetin, quercetin-3'-sulfate and quercetin-3-glucuronide in human breast cancer MCF-7 cells.
Qiu Wu, Paul W Needs, Yalong Lu, Paul A Kroon, Daoyuan Ren

Food Funct· March 2018

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Contribution of the Glucosinolate Fraction to the Overall Antioxidant Potential, Cytoprotection against Oxidative Insult and Antimicrobial Activity of Mill. Leaves Extract.
Maria Fernanda Taviano, Antonietta Melchini, Angela Filocamo, Chiara Costa, Stefania Catania, Paul Needs

Pharmacogn Mag· November 2017

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Interaction of quercetin and its metabolites with warfarin: Displacement of warfarin from serum albumin and inhibition of CYP2C9 enzyme.
Miklós Poór, Gabriella Boda, Paul W Needs, Paul A Kroon, Beáta Lemli

Biomed Pharmacother· April 2017

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Development, validation and evaluation of an analytical method for the determination of monomeric and oligomeric procyanidins in apple extracts.
Wendy J Hollands, Stefan Voorspoels, Griet Jacobs, Kjersti Aaby, Ane Meisland, Paul W Needs

J Chromatogr A· April 2017

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Molecular structure-function relationship of dietary polyphenols for inhibiting VEGF-induced VEGFR-2 activity.
Ana B Cerezo, Mark S Winterbone, Christina W A Moyle, Paul W Needs, Paul A Kroon

Mol Nutr Food Res· November 2015

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MK571 inhibits phase-2 conjugation of flavonols by Caco-2/TC7 cells, but does not specifically inhibit their apical efflux.
Robert D Barrington, Paul W Needs, Gary Williamson, Paul A Kroon

Biochem Pharmacol· June 2015

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Potent inhibition of VEGFR-2 activation by tight binding of green tea epigallocatechin gallate and apple procyanidins to VEGF: relevance to angiogenesis.
Christina W A Moyle, Ana B Cerezo, Mark S Winterbone, Wendy J Hollands, Yuri Alexeev, Paul W Needs

Mol Nutr Food Res· March 2015

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