Publications by authors named "Paul Timpson"

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A non-genetic, cell cycle-dependent mechanism of platinum resistance in lung adenocarcinoma.
Alvaro Gonzalez Rajal, Kamila A Marzec, Rachael A McCloy, Max Nobis, Venessa Chin, Jordan F Hastings, Kaitao Lai, Marina Kennerson, William E Hughes, Vijesh Vaghjiani

Elife· May 2021

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Inclusion of JNK-independent drugs within multiagent chemotherapy improves response in relapsed high-risk neuroblastoma.
Jeremy Z R Han, Monica Phimmachanh, Jordan F Hastings, King Ho Leong, Boaz H Ng, Paul Timpson

Sci Adv· November 2025

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ER stress disrupts insulin release in murine models of type 2 diabetes by impairing retromer action and constitutive secretion.
Nancy Sue, Le May Thai, Ebru Boslem, Kwan Yi Chu, Chenxu Yan, Paul Timpson

Cell Rep· May 2025

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Targeting the NPY/NPY1R signaling axis in mutant p53-dependent pancreatic cancer impairs metastasis.
Cecilia R Chambers, Supitchaya Watakul, Peter Schofield, Anna E Howell, Jessie Zhu, Paul Timpson

Sci Adv· March 2025

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Bystander Expression of Atypical Chemokine Receptor 2 Protects T Cells from Chemoattraction towards Cancer-Associated Fibroblasts.
Richard Tang, Szun S Tay, George Sharbeen, David Herrmann, Janet Youkhana, Paul Timpson

Eur J Immunol· February 2025

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Compression-dependent microtubule reinforcement enables cells to navigate confined environments.
Robert J Ju, Alistair D Falconer, Christanny J Schmidt, Marco A Enriquez Martinez, Kevin M Dean, Paul Timpson

Nat Cell Biol· September 2024

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Temporally resolved proteomics identifies nidogen-2 as a cotarget in pancreatic cancer that modulates fibrosis and therapy response.
Brooke A Pereira, Shona Ritchie, Cecilia R Chambers, Katie A Gordon, Astrid Magenau, Paul Timpson

Sci Adv· July 2024

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Tumor Biomechanics Alters Metastatic Dissemination of Triple Negative Breast Cancer via Rewiring Fatty Acid Metabolism.
Elysse C Filipe, Sipiththa Velayuthar, Ashleigh Philp, Max Nobis, Sharissa L Latham, Paul Timpson

Adv Sci (Weinh)· June 2024

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Fibroblast growth factor-induced lens fiber cell elongation is driven by the stepwise activity of Rho and Rac.
Yuki Sugiyama, Daniel A Reed, David Herrmann, Frank J Lovicu, Michael L Robinson, Paul Timpson

Development· February 2024

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Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and β-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth.
Michael S Samuel, Jose I Lopez, Ewan J McGhee, Daniel R Croft, David Strachan, Paul Timpson

Cancer Cell· February 2024

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Minimally invasive longitudinal intravital imaging of cellular dynamics in intact long bone.
Nayan Deger Bhattacharyya, Wunna Kyaw, Michelle M McDonald, Rama Dhenni, Abigail K Grootveld, Paul Timpson

Nat Protoc· December 2023

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Fibroblast Growth Factor-induced lens fiber cell elongation is driven by the stepwise activity of Rho and Rac.
Yuki Sugiyama, Daniel A Reed, David Herrmann, Frank J Lovicu, Michael L Robinson, Paul Timpson

bioRxiv· December 2023

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BCRP drives intrinsic chemoresistance in chemotherapy-naïve breast cancer brain metastasis.
Rebeca Uceda-Castro, Andreia S Margarido, Ji-Ying Song, Mark C de Gooijer, Hendrik A Messal, Paul Timpson

Sci Adv· October 2023

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A first-in-class pan-lysyl oxidase inhibitor impairs stromal remodeling and enhances gemcitabine response and survival in pancreatic cancer.
Jessica L Chitty, Michelle Yam, Lara Perryman, Amelia L Parker, Joanna N Skhinas, Paul Timpson

Nat Cancer· September 2023

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Therapeutic blockade of ER stress and inflammation prevents NASH and progression to HCC.
Ebru Boslem, Saskia Reibe, Rodrigo Carlessi, Benoit Smeuninx, Surafel Tegegne, Paul Timpson

Sci Adv· September 2023

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Monitoring AKT activity and targeting in live tissue and disease contexts using a real-time Akt-FRET biosensor mouse.
James R W Conway, Sean C Warren, Young-Kyung Lee, Andrew T McCulloch, Astrid Magenau, Paul Timpson

Sci Adv· April 2023

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Memory of stochastic single-cell apoptotic signaling promotes chemoresistance in neuroblastoma.
Jordan F Hastings, Sharissa L Latham, Alvin Kamili, Madeleine S Wheatley, Jeremy Z R Han, Paul Timpson

Sci Adv· March 2023

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Gene-Expression Profiling of Mucinous Ovarian Tumors and Comparison with Upper and Lower Gastrointestinal Tumors Identifies Markers Associated with Adverse Outcomes.
Nicola S Meagher, Kylie L Gorringe, Matthew Wakefield, Adelyn Bolithon, Chi Nam Ignatius Pang, Paul Timpson

Clin Cancer Res· December 2022

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Cell-derived Matrix Assays to Assess Extracellular Matrix Architecture and Track Cell Movement.
Kendelle J Murphy, Daniel A Reed, Cecilia R Chambers, Jessie Zhu, Astrid Magenau, Paul Timpson

Bio Protoc· December 2022

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Multiphoton intravital microscopy of rodents.
Colinda L G J Scheele, David Herrmann, Erika Yamashita, Cristina Lo Celso, Craig N Jenne, Paul Timpson

Nat Rev Methods Primers· November 2022

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Focal adhesion kinase priming in pancreatic cancer, altering biomechanics to improve chemotherapy.
Kendelle J Murphy, Jessie Zhu, Michael Trpceski, Brooke A Pereira, Paul Timpson

Biochem Soc Trans· August 2022

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Temporal profiling of the breast tumour microenvironment reveals collagen XII as a driver of metastasis.
Michael Papanicolaou, Amelia L Parker, Michelle Yam, Elysse C Filipe, Sunny Z Wu, Paul Timpson

Nat Commun· August 2022

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Pathway profiling of a novel SRC inhibitor, AZD0424, in combination with MEK inhibitors for cancer treatment.
John C Dawson, Alison Munro, Kenneth Macleod, Morwenna Muir, Paul Timpson

Mol Oncol· March 2022

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Annexin A6 and NPC1 regulate LDL-inducible cell migration and distribution of focal adhesions.
Jaimy Jose, Monira Hoque, Johanna Engel, Syed S Beevi, Mohamed Wahba, Paul Timpson

Sci Rep· January 2022

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Intravital imaging technology guides FAK-mediated priming in pancreatic cancer precision medicine according to Merlin status.
Kendelle J Murphy, Daniel A Reed, Claire Vennin, James R W Conway, Max Nobis, Paul Timpson

Sci Adv· October 2021

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Optimizing metastatic-cascade-dependent Rac1 targeting in breast cancer: Guidance using optical window intravital FRET imaging.
Alessia Floerchinger, Kendelle J Murphy, Sharissa L Latham, Sean C Warren, Andrew T McCulloch, Paul Timpson

Cell Rep· September 2021

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