Elife May 2021 PMID 33983115

A non-genetic, cell cycle-dependent mechanism of platinum resistance in lung adenocarcinoma.

Alvaro Gonzalez Rajal, Kamila A Marzec, Rachael A McCloy, Max Nobis, Venessa Chin, Jordan F Hastings, Kaitao Lai, Marina Kennerson, William E Hughes, Vijesh Vaghjiani, Paul Timpson, Jason E Cain, D Neil Watkins, David R Croucher, Andrew Burgess

Mentions

18
Peak: 5 in Jun 2021
across 4 sources since May 2021

Extended reach

394,461
potential audience

Total likes

37

Video views

129

Mentions per month

May 2021 – Aug 2021

Where it's discussed

  • X / Twitter10 posts
  • YouTube4 videos
  • News2 articles
  • Blogs2 articles

AI synopsis

What people are saying

Discussions highlight key aspects of the research, such as the role of the cell cycle in resistance and the importance of reproducibility, with phrases like 'building on previous research' and 'improved reproducibility' showing a forward-looking tone. Examples like the mention of early S phase cells' ability to resist treatment and the inclusion of RRIDs reflect both technical interest and appreciation for scientific rigor, illustrating a thoughtful engagement with the study's findings.

AgreementModerate agreement

Most discussions acknowledge the significance of discovering a non-genetic resistance mechanism, supporting the article's conclusions.

InterestModerate interest

Participants show curiosity about specific details like cell cycle phases and RRIDs, indicating moderate interest.

EngagementModerate engagement

Posts mention implications for research reproducibility and mechanisms involving cell cycle stages, reflecting active engagement.

ImpactModerate impact

The focus on advancing understanding of drug resistance and improving therapeutic strategies suggests perceived substantial impact.

Abstract in brief

  • Researchers found a new way lung adenocarcinoma cells resist the chemotherapy drug cisplatin without genetic changes, relying instead on the cell cycle stage during treatment.
  • Cells in early S phase can better recover and keep dividing after treatment because they experience less DNA damage, whereas cells in G1 or late S phase, especially when treated with certain inhibitors, show more damage and stop dividing.
  • This discovery suggests that the timing of cell cycle stages influences drug resistance, highlighting a nongenetic mechanism that could be targeted to improve cancer therapies.

Top posts

Most liked on X and Bluesky
eLife - the journal
@eLife · X

Building on previous research, Rajal et al. uncover a mechanism for the resistance to platinum chemotherapy in lung cancer (lung adenocarcinoma) that depends on the cell cycle and not genetics https://t.co/JcoAZcwuCq https://t.co/DDZsbxucMB

Aug 10, 2021 · 18 likes · 3 shares · 171,662 followers View post →
eLife - the journal
@eLife · X

Building on previous research, Rajal et al. uncover a mechanism for the resistance to platinum chemotherapy in lung cancer (lung adenocarcinoma) that depends on the cell cycle and not genetics https://t.co/JcoAZcwuCq https://t.co/gbKYhwz4FD

Aug 18, 2021 · 14 likes · 1 share · 171,662 followers View post →
NatureRevClinOncol
@NatRevClinOncol · X

Lung adenocarcinoma cells in early S phase have a greater ability to maintain proliferative capacity during cisplatin treatment, which correlated with reduced DNA damage over multiple generations: https://t.co/KYRXLnDn7w #LCSM

May 21, 2021 · 5 likes · 1 share · 41,523 followers View post →
Alexis Lomakin, Ph.D. (אל) אַלעקסיס לאָמאַקין
@Alexis_Lomakin · X

RT @eLife: Building on previous research, Rajal et al. uncover a mechanism for the resistance to platinum chemotherapy in lung cancer (lung…

Aug 10, 2021 · 3 shares · 3,646 followers View post →
Susan Heavey
@susan_heavey · X

RT @eLife: Building on previous research, Rajal et al. uncover a mechanism for the resistance to platinum chemotherapy in lung cancer (lung…

Aug 11, 2021 · 3 shares · 2,809 followers View post →
Química y Biología
@apuntesquimica · X

RT @eLife: Building on previous research, Rajal et al. uncover a mechanism for the resistance to platinum chemotherapy in lung cancer (lung…

Aug 18, 2021 · 1 share · 1,021 followers View post →

All mentions

Química y Biología
@apuntesquimica · X

RT @eLife: Building on previous research, Rajal et al. uncover a mechanism for the resistance to platinum chemotherapy in lung cancer (lung…

Aug 18, 2021 · 1 share · 1,021 followers View post →
eLife - the journal
@eLife · X

Building on previous research, Rajal et al. uncover a mechanism for the resistance to platinum chemotherapy in lung cancer (lung adenocarcinoma) that depends on the cell cycle and not genetics https://t.co/JcoAZcwuCq https://t.co/gbKYhwz4FD

Aug 18, 2021 · 14 likes · 1 share · 171,662 followers View post →
Susan Heavey
@susan_heavey · X

RT @eLife: Building on previous research, Rajal et al. uncover a mechanism for the resistance to platinum chemotherapy in lung cancer (lung…

Aug 11, 2021 · 3 shares · 2,809 followers View post →
Alexis Lomakin, Ph.D. (אל) אַלעקסיס לאָמאַקין
@Alexis_Lomakin · X

RT @eLife: Building on previous research, Rajal et al. uncover a mechanism for the resistance to platinum chemotherapy in lung cancer (lung…

Aug 10, 2021 · 3 shares · 3,646 followers View post →
eLife - the journal
@eLife · X

Building on previous research, Rajal et al. uncover a mechanism for the resistance to platinum chemotherapy in lung cancer (lung adenocarcinoma) that depends on the cell cycle and not genetics https://t.co/JcoAZcwuCq https://t.co/DDZsbxucMB

Aug 10, 2021 · 18 likes · 3 shares · 171,662 followers View post →
RRID Robot
@RobotRrid · X

The authors of "A non-genetic, cell cycle-dependent mechanism of p…" (https://t.co/hAaEIbahg2) included RRIDs in their paper! RRIDs like this improve reproducibility in scientific research. #accelerateopenscience #methodsmatter

Jul 3, 2021 · 161 followers View post →
RRID Robot
@RobotRrid · X

RRIDs were included in the eLife paper "A non-genetic, cell cycle-dependent mechanism of p…" (https://t.co/hAaEIbahg2). We appreciate the author's support of reproducibility. #STMpublishing #RRID

Jun 30, 2021 · 161 followers View post →
filippo masini
@filimasini · X

RT @NatRevClinOncol: Lung adenocarcinoma cells in early S phase have a greater ability to maintain proliferative capacity during cisplatin…

May 21, 2021 · 1 share · 770 followers View post →
NatureRevClinOncol
@NatRevClinOncol · X

Lung adenocarcinoma cells in early S phase have a greater ability to maintain proliferative capacity during cisplatin treatment, which correlated with reduced DNA damage over multiple generations: https://t.co/KYRXLnDn7w #LCSM

May 21, 2021 · 5 likes · 1 share · 41,523 followers View post →
Paperbirds_Oncology
@PaperbirdsO · X

New article: A non-genetic, cell cycle dependent mechanism of platinum resistance in lung adenocarcinoma https://t.co/wRYsb3Qiws #lungcancer #oncology https://t.co/yBap1otPu9

May 13, 2021 · 892 followers View post →