Publications by authors named "Paula L Hyland"

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Proteomic Identification of Plasma Biomarkers of Response to IL-5 Inhibitor Biologics in Healthy Subjects.
Lakshmi Manasa S Chekka, Deepti P Samarth, Kristina E Howard, Yan Guo, Esraa G Mohamed, Paula L Hyland

Clin Transl Sci· December 2025

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Evaluating miRNA Sequencing and Integrative Proteomics for Identifying Plasma miRNAs as Potential Pharmacodynamic Biomarkers of IFNβ-1a Biologics.
Mai Mehanna, Lakshmi Manasa Chekka, Barry A Rosenzweig, Deepti P Samarth, Esraa G Mohamed, Paula L Hyland

Clin Transl Sci· December 2025

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Characterization of Proteomic Pharmacodynamic Biomarkers of IFNβ-1a Biologics to Inform Potential Utility in Biosimilar Development.
Lakshmi Manasa S Chekka, Deepti P Samarth, Yan Guo, Esraa G Mohamed, Erica Decker, Paula L Hyland

Clin Pharmacol Ther· October 2025

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Assessment of drug permeability using a small airway microphysiological system.
Robert M Geiger, Shekh M Rahman, Md Shadiqur Rashid Roni, Catherine Sullenberger, Sabyasachy Mistry, Paula L Hyland

Front Pharmacol· July 2025

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A 3D Model of the Human Lung Airway for Evaluating Permeability of Inhaled Drugs.
Shekh M Rahman, Robert M Geiger, Md Shadiqur Rashid Roni, Isra Tariq, Omnia Ismaiel, Paula L Hyland

ACS Pharmacol Transl Sci· January 2025

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Leveraging in Vitro Models for Clinically Relevant Rare Variants in Pharmacogenomics.
Sydney Stern, Paula L Hyland, Michael Pacanowski, Robert N Schuck

Drug Metab Dispos· February 2024

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Considerations for Use of Pharmacodynamic Biomarkers to Support Biosimilar Development - (III) A Randomized Trial with Interferon Beta-1a Products.
Jeffry Florian, Victoria Gershuny, Qin Sun, Sarah J Schrieber, Murali K Matta, Paula L Hyland

Clin Pharmacol Ther· February 2023

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Evaluating the Utility of Proteomics for the Identification of Circulating Pharmacodynamic Biomarkers of IFNβ-1a Biologics.
Paula L Hyland, Lakshmi Manasa S Chekka, Deepti P Samarth, Barry A Rosenzweig, Erica Decker

Clin Pharmacol Ther· January 2023

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New science, drug regulation, and emergent public health issues: The work of FDA's division of applied regulatory science.
Kimberly Chiu, Rebecca Racz, Keith Burkhart, Jeffry Florian, Kevin Ford, Paula L Hyland

Front Med (Lausanne)· January 2023

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Expanding Approved Patient Populations for Rare Disease Treatment Using In Vitro Data.
James L Weaver, Wendy Wu, Paula L Hyland, Robert Lim, Patroula Smpokou

Clin Pharmacol Ther· July 2022

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Genome-wide association study of café-au-lait macule number in neurofibromatosis type 1.
Heejong Sung, Paula L Hyland, Alexander Pemov, Jeremy A Sabourin, Andrea M Baldwin

Mol Genet Genomic Med· October 2020

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Advancing Biosimilar Development Using Pharmacodynamic Biomarkers in Clinical Pharmacology Studies.
Junyi Li, Jeffry Florian, Elizabeth Campbell, Sarah J Schrieber, Jane P F Bai, Paula L Hyland

Clin Pharmacol Ther· January 2020

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Agnostic Pathway/Gene Set Analysis of Genome-Wide Association Data Identifies Associations for Pancreatic Cancer.
Naomi Walsh, Han Zhang, Paula L Hyland, Qi Yang, Evelina Mocci

J Natl Cancer Inst· June 2019

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Associations Between Prediagnostic Concentrations of Circulating Sex Steroid Hormones and Esophageal/Gastric Cardia Adenocarcinoma Among Men.
Jessica L Petrick, Paula L Hyland, Patrick Caron, Roni T Falk, Ruth M Pfeiffer

J Natl Cancer Inst· January 2019

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Association between circulating levels of sex steroid hormones and esophageal adenocarcinoma in the FINBAR Study.
Jessica L Petrick, Roni T Falk, Paula L Hyland, Patrick Caron, Ruth M Pfeiffer

PLoS One· February 2018

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Inherited variation in circadian rhythm genes and risks of prostate cancer and three other cancer sites in combined cancer consortia.
Fangyi Gu, Han Zhang, Paula L Hyland, Sonja Berndt, Susan M Gapstur

Int J Cancer· November 2017

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Association of high-evidence gastric cancer susceptibility loci and somatic gene expression levels with survival.
Hyuna Sung, Nan Hu, Howard H Yang, Carol A Giffen, Bin Zhu, Paula L Hyland

Carcinogenesis· October 2017

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GWAS follow-up study of esophageal squamous cell carcinoma identifies potential genetic loci associated with family history of upper gastrointestinal cancer.
Xin Song, Wen-Qing Li, Nan Hu, Xue Ke Zhao, Zhaoming Wang, Paula L Hyland

Sci Rep· July 2017

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Rare Germline Copy Number Variations and Disease Susceptibility in Familial Melanoma.
Jianxin Shi, Weiyin Zhou, Bin Zhu, Paula L Hyland, Hunter Bennett

J Invest Dermatol· December 2016

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Whole exome sequencing in families at high risk for Hodgkin lymphoma: identification of a predisposing mutation in the KDR gene.
Melissa Rotunno, Mary L McMaster, Joseph Boland, Sara Bass, Xijun Zhang, Paula L Hyland

Haematologica· July 2016

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A Powerful Procedure for Pathway-Based Meta-analysis Using Summary Statistics Identifies 43 Pathways Associated with Type II Diabetes in European Populations.
Han Zhang, William Wheeler, Paula L Hyland, Yifan Yang, Jianxin Shi

PLoS Genet· June 2016

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MEGSA: A Powerful and Flexible Framework for Analyzing Mutual Exclusivity of Tumor Mutations.
Xing Hua, Paula L Hyland, Jing Huang, Lei Song, Bin Zhu

Am J Hum Genet· March 2016

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Functional annotation of high-quality SNP biomarkers of gastric cancer susceptibility: the Yin Yang of PSCA rs2294008.
Hyuna Sung, Howard H Yang, Nan Hu, Hua Su, Philip R Taylor, Paula L Hyland

Gut· February 2016

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Pathway, in silico and tissue-specific expression quantitative analyses of oesophageal squamous cell carcinoma genome-wide association studies data.
Paula L Hyland, Han Zhang, Qi Yang, Howard H Yang, Nan Hu

Int J Epidemiol· February 2016

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Common genetic variants in epigenetic machinery genes and risk of upper gastrointestinal cancers.
Hyuna Sung, Howard H Yang, Han Zhang, Qi Yang, Nan Hu, Paula L Hyland

Int J Epidemiol· August 2015

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