Publications by authors named "Penelope D Ottewell"

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ATM inhibition increases the anti-tumor efficacy of radium-223 (Ra-223) against prostate cancer bone metastasis in preclinical models.
Diane V Lefley, Callum G Jones, Jiabao Zhou, Helen E Bryant, Spencer J Collis, Penelope D Ottewell

JBMR Plus· October 2025

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Cancer-Associated Fibroblasts Move and Interact More with Triple-Negative Breast Cancer Cells and Stimulate Their Proliferation in a Hyaluronan-Dependent Manner.
Sz-Ying Hou, Sarah C Macfarlane, Ariadna Gómez Torijano, Hyejeong Rosemary Kim, Marieke Rosier, Penelope D Ottewell

Cells· October 2025

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Losartan alters osteoblast differentiation and increases bone mass through inhibition of TGF signalling in vitro and in an OIM mouse model.
Mai Morita, Fawaz Arshad, Lewis A Quayle, Christopher N George, Diane V Lefley, Penelope D Ottewell

Bone Rep· September 2024

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The role of IL-1B in breast cancer bone metastasis.
Jiabao Zhou, Penelope D Ottewell

J Bone Oncol· June 2024

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MiR-662 is associated with metastatic relapse in early-stage breast cancer and promotes metastasis by stimulating cancer cell stemness.
Margherita Puppo, Manoj Kumar Valluru, Martine Croset, Davide Ceresa, Michele Iuliani, Penelope Dawn Ottewell

Br J Cancer· September 2023

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The CDK4/6 Inhibitor Palbociclib Inhibits Estrogen-Positive and Triple Negative Breast Cancer Bone Metastasis In Vivo.
Lubaid Saleh, Penelope D Ottewell, Janet E Brown, Steve L Wood, Nichola J Brown

Cancers (Basel)· April 2023

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Novel Methods of Targeting IL-1 Signalling for the Treatment of Breast Cancer Bone Metastasis.
Jiabao Zhou, Jennifer M Down, Christopher N George, Jessica Murphy, Diane V Lefley, Penelope D Ottewell

Cancers (Basel)· October 2022

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IL-1β in breast cancer bone metastasis.
Jiabao Zhou, Claudia Tulotta, Penelope D Ottewell

Expert Rev Mol Med· March 2022

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Oestradiol Contributes to Differential Antitumour Effects of Adjuvant Zoledronic Acid Observed Between Pre- and Post-Menopausal Women.
Victor G Canuas-Landero, Christopher N George, Diane V Lefley, Hannah Corness, Munitta Muthana, Penelope D Ottewell

Front Endocrinol (Lausanne)· February 2022

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Transcriptomic Profiling Reveals Novel Candidate Genes and Signalling Programs in Breast Cancer Quiescence and Dormancy.
Lewis A Quayle, Amy Spicer, Penelope D Ottewell, Ingunn Holen

Cancers (Basel)· August 2021

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IL-1B drives opposing responses in primary tumours and bone metastases; harnessing combination therapies to improve outcome in breast cancer.
Claudia Tulotta, Diane V Lefley, Charlotte K Moore, Ana E Amariutei, Amy R Spicer-Hadlington, Penelope D Ottewell

NPJ Breast Cancer· July 2021

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Osteoblast-Derived Paracrine and Juxtacrine Signals Protect Disseminated Breast Cancer Cells from Stress.
Russell Hughes, Xinyue Chen, Natasha Cowley, Penelope D Ottewell, Rhoda J Hawkins

Cancers (Basel)· March 2021

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Increased Abundance of Tumour-Associated Neutrophils in HPV-Negative Compared to HPV-Positive Oropharyngeal Squamous Cell Carcinoma Is Mediated by IL-1R Signalling.
Sarmad Al-Sahaf, Naeima B Hendawi, Bethany Ollington, Robert Bolt, Penelope D Ottewell

Front Oral Health· February 2021

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Combined administration of a small-molecule inhibitor of TRAF6 and Docetaxel reduces breast cancer skeletal metastasis and osteolysis.
Ryan T Bishop, Silvia Marino, Giovana Carrasco, Boya Li, Richard J Allen, Penelope D Ottewell

Cancer Lett· September 2020

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Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling.
Rachel Eyre, Denis G Alférez, Angélica Santiago-Gómez, Kath Spence, James C McConnell, Penelope D Ottewell

Nat Commun· November 2019

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The bone metastasis niche in breast cancer-potential overlap with the haematopoietic stem cell niche .
Gloria Allocca, Russell Hughes, Ning Wang, Hannah K Brown, Penelope D Ottewell

J Bone Oncol· August 2019

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Endogenous Production of IL1B by Breast Cancer Cells Drives Metastasis and Colonization of the Bone Microenvironment.
Claudia Tulotta, Diane V Lefley, Katy Freeman, Walter M Gregory, Andrew M Hanby, Penelope D Ottewell

Clin Cancer Res· May 2019

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Pharmacological inhibition of the IKKε/TBK-1 axis potentiates the anti-tumour and anti-metastatic effects of Docetaxel in mouse models of breast cancer.
Ryan T Bishop, Silvia Marino, Daniëlle de Ridder, Richard J Allen, Diane V Lefley, Penelope D Ottewell

Cancer Lett· May 2019

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The IL-1/IL-1R axis induces greater fibroblast-derived chemokine release in human papillomavirus-negative compared to positive oropharyngeal cancer.
Sarmad Al-Sahaf, Keith D Hunter, Robert Bolt, Penelope D Ottewell, Craig Murdoch

Int J Cancer· January 2019

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Chemotherapy resistance and stemness in mitotically quiescent human breast cancer cells identified by fluorescent dye retention.
Lewis A Quayle, Penelope D Ottewell, Ingunn Holen

Clin Exp Metastasis· December 2018

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Parathyroid Hormone (PTH) Increases Skeletal Tumour Growth and Alters Tumour Distribution in an In Vivo Model of Breast Cancer.
Hannah K Brown, Gloria Allocca, Penelope D Ottewell, Ning Wang, Nicola J Brown

Int J Mol Sci· September 2018

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Erratum to: Loss of plakoglobin promotes cell-cell contact, increased invasion and breast cancer cell dissemination in vivo.
Ingunn Holen, Jacob Whitworth, Faith Nutter, Alyson Evans, Hannah K Brown, Penelope D Ottewell

Breast Cancer Res· March 2017

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The role of osteoblasts in bone metastasis.
Penelope D Ottewell

J Bone Oncol· September 2016

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Murine models of breast cancer bone metastasis.
Laura E Wright, Penelope D Ottewell, Nadia Rucci, Olivier Peyruchaud, Gabriel M Pagnotti

Bonekey Rep· May 2016

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CAPG and GIPC1: Breast Cancer Biomarkers for Bone Metastasis Development and Treatment.
Jules A Westbrook, David A Cairns, Jianhe Peng, Valerie Speirs, Andrew M Hanby, Penelope D Ottewell

J Natl Cancer Inst· April 2016

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