Publications by authors named "Pengxing He"

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The targeting of AKR1C1 synergizes with gefitinib via the STAT3 signaling pathway in -mutated NSCLC.
Linlin Chang, Shuzhen Wei, Xiaotian Qi, Yang Gao, Jinhua Chen, Pengxing He

Genes Dis· November 2025

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Structure-Based Design of New LSD1/EGFR Dual Inhibitors for Treating EGFR Mutant NSCLC Cancers.
Jingya Zhang, Pengxing He, Wenwen Wang, Yuxing Wang, Han Yang

J Med Chem· March 2025

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A Helicene-Based Single-Molecule Inductor and Capacitor with Frequency-Dependent Charge-Transport Pathways.
Pengxing He, Jingyao Ye, Junrui Zhang, Taige Lu, Wenying Cui, Chengshuo Shen

Angew Chem Int Ed Engl· January 2025

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The combination of SLC7A11 inhibitor and oridonin synergistically inhibits cervical cancer cell growth by decreasing the NADPH/NADP ratio.
Yajie Liu, Pengxing He, Xubin Ma, Yingqi Tian, Yu Zhang

Genes Dis· January 2025

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PIK3IP1: structure, aberration, function, and regulation in diseases.
Yingjie Jia, Pengxing He, Xubin Ma, Kaili Lv, Ying Liu

Eur J Pharmacol· August 2024

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Heat shock protein 90: biological functions, diseases, and therapeutic targets.
Huiyun Wei, Yingying Zhang, Yilin Jia, Xunan Chen, Tengda Niu, Pengxing He

MedComm (2020)· February 2024

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Design, synthesis and biological evaluation of structurally new 4-indolyl quinazoline derivatives as highly potent, selective and orally bioavailable EGFR inhibitors.
Pengxing He, Linna Du, Qingqing Dai, Guobo Li, Bin Yu

Bioorg Chem· January 2024

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Discovery of YS-363 as a highly potent, selective, and orally efficacious EGFR inhibitor.
Pengxing He, Jing Jing, Linna Du, Xuyang Zhang, Yufei Ren

Biomed Pharmacother· November 2023

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Inhibition of LSD1 induces ferroptosis through the ATF4-xCT pathway and shows enhanced anti-tumor effects with ferroptosis inducers in NSCLC.
Linna Du, Han Yang, Yufei Ren, Yanli Ding, Yichao Xu, Pengxing He

Cell Death Dis· November 2023

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Inhibition of lysine-specific demethylase 1 (LSD1) prevented tumor growth and metastasis by downregulating PD-L1 expression in lung adenocarcinoma.
Pengxing He, Linna Du, Pan Hao, Han Yang, Yufei Ren

Genes Dis· September 2023

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Inhibition of lysine-specific demethylase 1 enhances the sensitivity of the chemotherapeutic drug doxorubicin in gastric cancer cell.
Xu-Yang Zhang, Pan Hao, Jun-Wei Wang, Wen Zhao, Hong-Min Liu, Peng-Xing He

Mol Biol Rep· January 2023

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Effective Approach toward Selective Near-Infrared Dyes: Rational Design, Synthesis, and Characterization of Thieno[3,4-]thiophene-Based Quinoidal Oligomers.
Yuxuan Hei, Xinwei Zhang, Pengxing He, Eric Jiahan Zhao, Edison Tang

ACS Appl Mater Interfaces· December 2022

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ATRA promotes PD-L1 expression to control gastric cancer immune surveillance.
Zhi-Lu Ma, Yan-Li Ding, Jing Jing, Lin-Na Du, Xu-Yang Zhang, Peng-Xing He

Eur J Pharmacol· April 2022

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Abrogation of USP7 is an alternative strategy to downregulate PD-L1 and sensitize gastric cancer cells to T cells killing.
Zhiru Wang, Wenting Kang, Ouwen Li, Fengyu Qi, Junwei Wang, Pengxing He, Zhenhe Suo, Yichao Zheng

Acta Pharm Sin B· March 2021

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Expression of programmed death ligand 1 (PD-L1) is associated with metastasis and differentiation in gastric cancer.
Peng-Xing He, Zhi-Lu Ma, Huan Han, Xu-Yang Zhang, Sheng-Hui Niu, Yi-Chao Zheng

Life Sci· February 2020

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Correction: Down-regulation of G9a triggers DNA damage response and inhibits colorectal cancer cells proliferation.
Jie Zhang, Pengxing He, Yong Xi, Meiyu Geng, Yi Chen

Oncotarget· January 2020

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Discovery of WS-157 as a highly potent, selective and orally active EGFR inhibitor.
Pengxing He, Shenghui Niu, Shuai Wang, Xiaojing Shi, Siqi Feng

Acta Pharm Sin B· November 2019

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G9a stimulates CRC growth by inducing p53 Lys373 dimethylation-dependent activation of .
Jie Zhang, Yafang Wang, Yanyan Shen, Pengxing He, Jian Ding, Yi Chen

Theranostics· May 2019

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Down-regulation of G9a triggers DNA damage response and inhibits colorectal cancer cells proliferation.
Jie Zhang, Pengxing He, Yong Xi, Meiyu Geng, Yi Chen

Oncotarget· February 2015

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G226, a new epipolythiodioxopiperazine derivative, triggers DNA damage and apoptosis in human cancer cells in vitro via ROS generation.
Peng-xing He, Jie Zhang, Yong-sheng Che, Qiao-jun He, Yi Chen

Acta Pharmacol Sin· December 2014

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G226, a novel epipolythiodioxopiperazine derivative, induces autophagy and caspase-dependent apoptosis in human breast cancer cells in vitro.
Peng-xing He, Yong-sheng Che, Qiao-jun He, Yi Chen, Jian Ding

Acta Pharmacol Sin· August 2014

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