Publications by authors named "Perihan A Elzahhar"

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Click-modifiable isatin hydrazones as COX-2, VEGFR-2, and carbonic anhydrase inhibitors: A multi-target approach to cancer therapy.
Maryam A Z El-Attar, Ola S Afifi, Azza Ismail, Yasmine N Kamel, Hend A Yassin, Perihan A Elzahhar

Eur J Med Chem· January 2026

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Revisiting multi-pathway modulation with theophylline derivatives: Targeting STAT3, NF-κB, and apoptotic signaling in breast cancer.
Ola S Afifi, Amira A Abdellatef, Heba A Abd El Razik, Shams El-Dine A Shams El-Dine, Alaa A El-Tombary, Perihan A Elzahhar

Bioorg Chem· August 2025

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Multi-Target Glitazones for Modulating Peroxisome Proliferator-Activated Receptor-γ, Cyclooxygenase-2, and Carbonic Anhydrases for the Management of Metabolic Dysfunction.
Perihan A Elzahhar, Hisham A Nematalla, Malak A Abouayana, El Sayed H El Ashry, Mahmoud Balbaa

ACS Pharmacol Transl Sci· June 2025

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Novel thiazolones for the simultaneous modulation of PPARγ, COX-2 and 15-LOX to address metabolic disease-associated portal inflammation.
Mai S El-Shoukrofy, Azza Ismail, Reem H Elhamammy, Sherien A Abdelhady, Rasha Nassra, Perihan A Elzahhar

Eur J Med Chem· May 2025

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Chromone-based small molecules for multistep shutdown of arachidonate pathway: Simultaneous inhibition of COX-2, 15-LOX and mPGES-1 enzymes.
Perihan A Elzahhar, Rebecca Orioli, Nayera W Hassan, Silvia Gobbi, Federica Belluti

Eur J Med Chem· February 2024

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New 2-alkoxycyanopyridine derivatives as inhibitors of EGFR, HER2, and DHFR: Synthesis, anticancer evaluation, and molecular modeling studies.
Samia S Hawas, Selwan M El-Sayed, Perihan A Elzahhar, Mohamed A Moustafa

Bioorg Chem· December 2023

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Thermogenic Modulation of Adipose Depots: A Perspective on Possible Therapeutic Intervention with Early Cardiorenal Complications of Metabolic Impairment.
Ahmed F El-Yazbi, Mohamed A Elrewiny, Hosam M Habib, Ali H Eid, Perihan A Elzahhar

Mol Pharmacol· November 2023

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Modulating leishmanial pteridine metabolism machinery via some new coumarin-1,2,3-triazoles: Design, synthesis and computational studies.
Nayera W Hassan, Ahmed Sabt, Maryam A Z El-Attar, Mikko Ora, Alaa El-Din A Bekhit, Perihan A Elzahhar

Eur J Med Chem· May 2023

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Inclusion of Nitrofurantoin into the Realm of Cancer Chemotherapy via Biology-Oriented Synthesis and Drug Repurposing.
Perihan A Elzahhar, Hisham A Nematalla, Houssam Al-Koussa, Carla Abrahamian, Amira F El-Yazbi

J Med Chem· April 2023

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Insights on the in-vitro binding interaction between donepezil and bovine serum albumin.
Reem N El Gammal, Heba Elmansi, Ali A El-Emam, Fathalla Belal, Perihan A Elzahhar

BMC Chem· April 2023

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Challenging inflammatory process at molecular, cellular and in vivo levels via some new pyrazolyl thiazolones.
Perihan A Elzahhar, Rana A Alaaeddine, Rasha Nassra, Azza Ismail, Hala F Labib

J Enzyme Inhib Med Chem· December 2021

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The Emerging Role of COX-2, 15-LOX and PPARγ in Metabolic Diseases and Cancer: An Introduction to Novel Multi-target Directed Ligands (MTDLs).
Rana A Alaaeddine, Perihan A Elzahhar, Ibrahim AlZaim, Wassim Abou-Kheir, Ahmed S F Belal

Curr Med Chem· May 2021

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Expanding the anticancer potential of 1,2,3-triazoles via simultaneously targeting Cyclooxygenase-2, 15-lipoxygenase and tumor-associated carbonic anhydrases.
Perihan A Elzahhar, Shrouk M Abd El Wahab, Mohamed Elagawany, Hoda Daabees, Ahmed S F Belal

Eur J Med Chem· August 2020

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Novel pyrazine based anti-tubercular agents: Design, synthesis, biological evaluation and in silico studies.
Nayera W Hassan, Manal N Saudi, Yasser S Abdel-Ghany, Azza Ismail, Perihan A Elzahhar

Bioorg Chem· March 2020

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Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase.
Ehab D AlFadly, Perihan A Elzahhar, Anna Tramarin, Salwa Elkazaz, Hossam Shaltout

Eur J Med Chem· April 2019

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Shooting three inflammatory targets with a single bullet: Novel multi-targeting anti-inflammatory glitazones.
Perihan A Elzahhar, Rana Alaaeddine, Tamer M Ibrahim, Rasha Nassra, Azza Ismail

Eur J Med Chem· April 2019

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Anti-leishmanial click modifiable thiosemicarbazones: Design, synthesis, biological evaluation and in silico studies.
Mohamed G Temraz, Perihan A Elzahhar, Alaa El-Din A Bekhit, Adnan A Bekhit, Hala F Labib

Eur J Med Chem· May 2018

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Design and synthesis of some new 2,3'-bipyridine-5-carbonitriles as potential anti-inflammatory/antimicrobial agents.
Perihan A Elzahhar, Salwa Elkazaz, Raafat Soliman, Alaa A El-Tombary, Hossam A Shaltout

Future Med Chem· August 2017

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Design, synthesis and antimicrobial evaluation of methyl pyridyl-2,4- dioxobutanoates and some new derived ring systems.
Perihan A S Elzahhar, Raafat Soliman, Soad A M El-Hawash, Hanan M A Ragab, Amal M Youssef

Med Chem· February 2016

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Design, synthesis and biological screening of some pyridinylpyrazole and pyridinylisoxazole derivatives as potential anti-inflammatory, analgesic, antipyretic and antimicrobial agents.
Soad A M El-Hawash, Raafat Soliman, Amal M Youssef, Hanan M A Ragab, Perihan A S Elzahhar

Med Chem· May 2014

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