Publications by authors named "Peter D J Grootenhuis"

Claim this Profile
I
Insights into regioselective metabolism of mefenamic acid by cytochrome P450 BM3 mutants through crystallography, docking, molecular dynamics, and free energy calculations.
Luigi Capoferri, Rasmus Leth, Ernst ter Haar, Arun K Mohanty, Peter D J Grootenhuis

Proteins· March 2016

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery of N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide (VX-770, ivacaftor), a potent and orally bioavailable CFTR potentiator.
Sabine Hadida, Fredrick Van Goor, Jinglan Zhou, Vijayalaksmi Arumugam, Jason McCartney, Peter D J Grootenhuis

J Med Chem· December 2014

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809.
Fredrick Van Goor, Sabine Hadida, Peter D J Grootenhuis, Bill Burton, Jeffrey H Stack

Proc Natl Acad Sci U S A· November 2011

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
E
Efficient screening of cytochrome P450 BM3 mutants for their metabolic activity and diversity toward a wide set of drug-like molecules in chemical space.
Jelle Reinen, Jolanda S van Leeuwen, Yongmin Li, Lifang Sun, Peter D J Grootenhuis

Drug Metab Dispos· September 2011

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
R
Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770.
Fredrick Van Goor, Sabine Hadida, Peter D J Grootenhuis, Bill Burton, Dong Cao

Proc Natl Acad Sci U S A· November 2009

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
R
Rescue of DeltaF508-CFTR trafficking and gating in human cystic fibrosis airway primary cultures by small molecules.
Fredrick Van Goor, Kimberly S Straley, Dong Cao, Jesús González, Sabine Hadida, Peter D J Grootenhuis

Am J Physiol Lung Cell Mol Physiol· June 2006

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
H
High throughput P450 inhibition screens in early drug discovery.
Gregor Zlokarnik, Peter D J Grootenhuis, John B Watson

Drug Discov Today· November 2005

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
W
Water-soluble molecular capsules: self-assembly and binding properties.
Francesca Corbellini, Ronald M A Knegtel, Peter D J Grootenhuis, Mercedes Crego-Calama, David N Reinhoudt

Chemistry· December 2004

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
In silico prediction of drug safety: despite progress there is abundant room for improvement.
William J Egan, Gregor Zlokarnik, Peter D J Grootenhuis

Drug Discov Today Technol· December 2004

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Design of a gene family screening library targeting G-protein coupled receptors.
Michelle L Lamb, Erin K Bradley, Graham Beaton, Steven S Bondy, Angelo J Castellino, Peter D J Grootenhuis

J Mol Graph Model· September 2004

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
N
N-phenylphenylglycines as novel corticotropin releasing factor receptor antagonists.
Valentina Molteni, Julie Penzotti, Dean M Wilson, Andreas P Termin, Long Mao, Peter D J Grootenhuis

J Med Chem· May 2004

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Performance of 3D-database molecular docking studies into homology models.
Connie Oshiro, Erin K Bradley, John Eksterowicz, Erik Evensen, Michelle L Lamb, Peter D J Grootenhuis

J Med Chem· January 2004

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Comparing performance of computational tools for combinatorial library design.
Erik Evensen, John E Eksterowicz, Robert V Stanton, Connie Oshiro, Peter D J Grootenhuis

J Med Chem· November 2003

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Predicting passive transport in silico--history, hype, hope.
David E Clark, Peter D J Grootenhuis

Curr Top Med Chem· September 2003

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Informative library design as an efficient strategy to identify and optimize leads: application to cyclin-dependent kinase 2 antagonists.
Erin K Bradley, Jennifer L Miller, Eddine Saiah, Peter D J Grootenhuis

J Med Chem· September 2003

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
U
Unique overlap in the prerequisites for thrombin inhibition and oral bioavailability resulting in potent oral antithrombotics.
Anton E P Adang, Adrianus P A de Man, Gerard M T Vogel, Peter D J Grootenhuis, Martin J Smit

J Med Chem· September 2002

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
E
Evaluation of a novel shape-based computational filter for lead evolution: application to thrombin inhibitors.
Jayashree Srinivasan, Angelo Castellino, Erin K Bradley, John E Eksterowicz, Peter D J Grootenhuis

J Med Chem· June 2002

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Coupling structure-based design with combinatorial chemistry: application of active site derived pharmacophores with informative library design.
John E Eksterowicz, Erik Evensen, Christian Lemmen, G Patrick Brady, J Kevin Lanctot, Peter D J Grootenhuis

J Mol Graph Model· June 2002

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Arylamidrazones as novel corticotropin releasing factor receptor antagonists.
Dean M Wilson, Andreas P Termin, Long Mao, Michele M Ramirez-Weinhouse, Valentina Molteni, Peter D J Grootenhuis

J Med Chem· May 2002

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Progress in computational methods for the prediction of ADMET properties.
David E Clark, Peter D J Grootenhuis

Curr Opin Drug Discov Devel· May 2002

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
A computational ensemble pharmacophore model for identifying substrates of P-glycoprotein.
Julie E Penzotti, Michelle L Lamb, Erik Evensen, Peter D J Grootenhuis

J Med Chem· April 2002

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
A method to identify and screen libraries of guests that complex to a synthetic host.
Menno R de Jong, Ronald M A Knegtel, Peter D J Grootenhuis, Jurriaan Huskens, David N Reinhoudt

Angew Chem Int Ed Engl· March 2002

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis