Publications by authors named "Peter Drain"

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Insulin secretion deficits in a Prader-Willi syndrome β-cell model are associated with a concerted downregulation of multiple endoplasmic reticulum chaperones.
Erik A Koppes, Marie A Johnson, James J Moresco, Patrizia Luppi, Dale W Lewis, Peter Drain

PLoS Genet· April 2023

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Riding the rapids: COVID-19, the three rivers curriculum, and the experiences of the University of Pittsburgh School of Medicine.
D Michael Elnicki, Peter Drain, Greg Null, Jason Rosenstock, Ann Thompson

FASEB Bioadv· May 2021

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Autocrine C-peptide protects INS1 β cells against palmitic acid-induced oxidative stress in peroxisomes by inducing catalase.
Patrizia Luppi, Nicholas Drain, Ramsey To, Donna Stolz, Callen Wallace, Peter Drain

Endocrinol Diabetes Metab· July 2020

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Uncoupling a unique couple by chopping off one of its tails: insights into the K channels of the heart and pancreas.
Patrizia Luppi, Peter Drain

J Physiol· December 2018

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Glucose but not KCl diminishes submembrane granule turnover in mouse beta-cells.
Dennis Brüning, Kirstin Reckers, Peter Drain, Ingo Rustenbeck

J Mol Endocrinol· October 2017

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Autocrine C-peptide mechanism underlying INS1 beta cell adaptation to oxidative stress.
Patrizia Luppi, Peter Drain

Diabetes Metab Res Rev· October 2014

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ATP and sulfonylurea linkage in the K(ATP) channel solves a diabetes puzzler.
Peter Drain

Diabetes· November 2013

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Differential regulation and localization of carboxypeptidase D and carboxypeptidase E in human and mouse β-cells.
Kwan Yi Chu, Meredith J L Briggs, Tobias Albrecht, Peter F Drain, James D Johnson

Islets· November 2011

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Global deficits in development, function, and gene expression in the endocrine pancreas in a deletion mouse model of Prader-Willi syndrome.
Mihaela Stefan, Rebecca A Simmons, Suzanne Bertera, Massimo Trucco, Farzad Esni, Peter Drain

Am J Physiol Endocrinol Metab· May 2011

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α-Synuclein binds the K(ATP) channel at insulin-secretory granules and inhibits insulin secretion.
Xuehui Geng, Haiyan Lou, Jian Wang, Lehong Li, Alexandra L Swanson, Peter Drain

Am J Physiol Endocrinol Metab· February 2011

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Antidiabetic sulfonylurea stimulates insulin secretion independently of plasma membrane KATP channels.
Xuehui Geng, Lehong Li, Rita Bottino, A N Balamurugan, Suzanne Bertera, Peter Drain

Am J Physiol Endocrinol Metab· July 2007

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Human insulin vesicle dynamics during pulsatile secretion.
Darren J Michael, Wenyong Xiong, Xuehui Geng, Peter Drain, Robert H Chow

Diabetes· May 2007

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Derlin-1 promotes the efficient degradation of the cystic fibrosis transmembrane conductance regulator (CFTR) and CFTR folding mutants.
Fei Sun, Ruilin Zhang, Xiaoyan Gong, Xuehui Geng, Peter F Drain

J Biol Chem· December 2006

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Carbon monoxide differentially inhibits TLR signaling pathways by regulating ROS-induced trafficking of TLRs to lipid rafts.
Kiichi Nakahira, Hong Pyo Kim, Xue Hui Geng, Atsunori Nakao, Xue Wang, Peter F Drain

J Exp Med· October 2006

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Ligand-dependent linkage of the ATP site to inhibition gate closure in the KATP channel.
Lehong Li, Xuehui Geng, Michael Yonkunas, Anjey Su, Erik Densmore, Peter Drain

J Gen Physiol· September 2005

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Fluorescent cargo proteins in pancreatic beta-cells: design determines secretion kinetics at exocytosis.
Darren J Michael, Xuehui Geng, Niamh X Cawley, Y Peng Loh, Christopher J Rhodes, Peter Drain

Biophys J· December 2004

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Concerted gating mechanism underlying KATP channel inhibition by ATP.
Peter Drain, Xuehui Geng, Lehong Li

Biophys J· April 2004

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Body window-enabled in vivo multicolor imaging of transplanted mouse islets expressing an insulin-Timer fusion protein.
Suzanne Bertera, Xuehui Geng, Zakaria Tawadrous, Rita Bottino, A N Balamurugan, Peter Drain

Biotechniques· October 2003

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The insulin secretory granule is the major site of K(ATP) channels of the endocrine pancreas.
Xuehui Geng, Lehong Li, Simon Watkins, Paul D Robbins, Peter Drain

Diabetes· March 2003

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A functional link between glucokinase binding to insulin granules and conformational alterations in response to glucose and insulin.
Megan A Rizzo, Mark A Magnuson, Peter F Drain, David W Piston

J Biol Chem· September 2002

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Imaging secretory vesicles by fluorescent protein insertion in propeptide rather than mature secreted peptide.
Simon Watkins, Xuehui Geng, Lehong Li, Glenn Papworth, Paul D Robbins, Peter Drain

Traffic· July 2002

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Open state destabilization by ATP occupancy is mechanism speeding burst exit underlying KATP channel inhibition by ATP.
Lehong Li, Xuehui Geng, Peter Drain

J Gen Physiol· January 2002

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