Publications by authors named "Peter Fraser"

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Discovery and characterisation of VPRBP/DCAF1 kinase inhibitor analogues as microtubular destabilising agents with potent anti-myeloma activity.
Olivia Susanto, Emily Gruber, Cheng Mun Wun, Rheana L Franich, Xiao Ma, Peter J Fraser

Mol Cancer Ther· November 2025

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A CDK11-dependent RNA polymerase II pause-checkpoint precedes CDK9-mediated transition to transcriptional elongation.
Jennifer R Devlin, Ben Martin, Nenad Bartonicek, Keziah Ting, Zheng Fan, Peter Fraser

Mol Cell· September 2025

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HMGA1 orchestrates chromatin compartmentalization and sequesters genes into 3D networks coordinating senescence heterogeneity.
Ioana Olan, Masami Ando-Kuri, Aled J Parry, Tetsuya Handa, Stefan Schoenfelder, Peter Fraser

Nat Commun· August 2024

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p53 rapidly restructures 3D chromatin organization to trigger a transcriptional response.
François Serra, Andrea Nieto-Aliseda, Lucía Fanlo-Escudero, Llorenç Rovirosa, Mónica Cabrera-Pasadas, Peter Fraser

Nat Commun· April 2024

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The genetic regulatory architecture and epigenomic basis for age-related changes in rattlesnake venom.
Michael P Hogan, Matthew L Holding, Gunnar S Nystrom, Timothy J Colston, Daniel A Bartlett, Peter Fraser

Proc Natl Acad Sci U S A· April 2024

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Cellular reprogramming is driven by widespread rewiring of promoter-enhancer interactions.
Miao Wang, Bing He, Yueling Hao, Divyaa Srinivasan, Jatin Shrinet, Peter Fraser

BMC Biol· November 2023

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Rationally designed chimeric PI3K-BET bromodomain inhibitors elicit curative responses in MYC-driven lymphoma.
Danielle H Oh, Xiao Ma, Simon J Hogg, Jackson He, Conor Kearney, Peter Fraser

Proc Natl Acad Sci U S A· September 2023

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Intra- and interchromosomal contact mapping reveals the Igh locus has extensive conformational heterogeneity and interacts with B-lineage genes.
Olga Mielczarek, Carolyn H Rogers, Yinxiu Zhan, Louise S Matheson, Michael J T Stubbington, Peter Fraser

Cell Rep· September 2023

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Single cell Hi-C identifies plastic chromosome conformations underlying the gastrulation enhancer landscape.
Nimrod Rappoport, Elad Chomsky, Takashi Nagano, Charlie Seibert, Yaniv Lubling, Peter Fraser

Nat Commun· June 2023

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3D genome organization links non-coding disease-associated variants to genes.
Gisela Orozco, Stefan Schoenfelder, Nicolas Walker, Stephan Eyre, Peter Fraser

Front Cell Dev Biol· October 2022

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Inhibition of mutant IDH1 promotes cycling of acute myeloid leukemia stem cells.
Emily Gruber, Joan So, Alexander C Lewis, Rheana Franich, Rachel Cole, Peter Fraser

Cell Rep· August 2022

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DeepLoop robustly maps chromatin interactions from sparse allele-resolved or single-cell Hi-C data at kilobase resolution.
Shanshan Zhang, Dylan Plummer, Leina Lu, Jian Cui, Wanying Xu, Peter Fraser

Nat Genet· July 2022

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Epigenetic Activation of Plasmacytoid DCs Drives IFNAR-Dependent Therapeutic Differentiation of AML.
Jessica M Salmon, Izabela Todorovski, Kym L Stanley, Claudia Bruedigam, Conor J Kearney, Peter J Fraser

Cancer Discov· June 2022

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Chromosome organization through the cell cycle at a glance.
Divyaa Srinivasan, Tarak Shisode, Jatin Shrinet, Peter Fraser

J Cell Sci· May 2022

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Locus-specific induction of gene expression from heterochromatin loci during cellular senescence.
Kosuke Tomimatsu, Dóra Bihary, Ioana Olan, Aled J Parry, Stefan Schoenfelder, Peter Fraser

Nat Aging· January 2022

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Short- and long-range cis interactions between integrated HPV genomes and cellular chromatin dysregulate host gene expression in early cervical carcinogenesis.
Ian J Groves, Emma L A Drane, Marco Michalski, Jack M Monahan, Cinzia G Scarpini, Peter Fraser

PLoS Pathog· August 2021

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The global and promoter-centric 3D genome organization temporally resolved during a circadian cycle.
Mayra Furlan-Magaril, Masami Ando-Kuri, Rodrigo G Arzate-Mejía, Jörg Morf, Jonathan Cairns, Peter Fraser

Genome Biol· June 2021

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Genetic perturbation of PU.1 binding and chromatin looping at neutrophil enhancers associates with autoimmune disease.
Stephen Watt, Louella Vasquez, Klaudia Walter, Alice L Mann, Kousik Kundu, Peter Fraser

Nat Commun· April 2021

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High-resolution three-dimensional chromatin profiling of the Chinese hamster ovary cell genome.
Stephen Bevan, Stefan Schoenfelder, Robert J Young, Lin Zhang, Simon Andrews, Peter Fraser

Biotechnol Bioeng· February 2021

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Highly interconnected enhancer communities control lineage-determining genes in human mesenchymal stem cells.
Jesper G S Madsen, Maria S Madsen, Alexander Rauch, Sofie Traynor, Elvira L Van Hauwaert, Peter Fraser

Nat Genet· November 2020

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Transcription-dependent cohesin repositioning rewires chromatin loops in cellular senescence.
Ioana Olan, Aled J Parry, Stefan Schoenfelder, Masako Narita, Yoko Ito, Peter Fraser

Nat Commun· November 2020

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Analysis of chromatin organization and gene expression in T cells identifies functional genes for rheumatoid arthritis.
Jing Yang, Amanda McGovern, Paul Martin, Kate Duffus, Xiangyu Ge, Peter Fraser

Nat Commun· September 2020

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Cohesin-Dependent and -Independent Mechanisms Mediate Chromosomal Contacts between Promoters and Enhancers.
Michiel J Thiecke, Gordana Wutz, Matthias Muhar, Wen Tang, Stephen Bevan, Peter Fraser

Cell Rep· July 2020

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Active and repressed biosynthetic gene clusters have spatially distinct chromosome states.
Hans-Wilhelm Nützmann, Daniel Doerr, América Ramírez-Colmenero, Jesús Emiliano Sotelo-Fonseca, Eva Wegel, Peter Fraser

Proc Natl Acad Sci U S A· June 2020

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Parental-to-embryo switch of chromosome organization in early embryogenesis.
Samuel Collombet, Noémie Ranisavljevic, Takashi Nagano, Csilla Varnai, Tarak Shisode, Peter Fraser

Nature· April 2020

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