Publications by authors named "Peter Fu"

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An efficient enzymatic system for studying structure-carcinogenicity relationships: metabolism of pyrrolizidine alkaloids by human liver microsomes in the presence of calf thymus DNA, resulting in the formation of DNA adducts.
Xiaobo He, Qingsu Xia, Matthew S Bryant, Peter P Fu

J Environ Sci Health C Toxicol Carcinog· May 2025

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Hepatotoxicity screening and ranking of structurally different pyrrolizidine alkaloids in zebrafish.
Yueyang Pan, Jiang Ma, Hui Zhao, Peter P Fu, Ge Lin

Food Chem Toxicol· August 2023

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Formation of DHP-DNA Adducts from Rat Liver Microsomal Metabolism of 1,2-Unsaturated Pyrrolizidine Alkaloid-Containing Plant Extracts and Dietary Supplements.
Xiaobo He, Qingsu Xia, Lin Zhu, Yisheng He, Matthew S Bryant, Peter P Fu

Chem Res Toxicol· February 2023

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Correlation Investigation between Pyrrole-DNA and Pyrrole-Protein Adducts in Male ICR Mice Exposed to Retrorsine, a Hepatotoxic Pyrrolizidine Alkaloid.
Lin Zhu, Junyi Xue, Yisheng He, Qingsu Xia, Peter P Fu

Toxins (Basel)· May 2022

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Liquorice Extract and 18β-Glycyrrhetinic Acid Protect Against Experimental Pyrrolizidine Alkaloid-Induced Hepatotoxicity in Rats Through Inhibiting Cytochrome P450-Mediated Metabolic Activation.
Zhangting Wang, Jiang Ma, Sheng Yao, Yisheng He, Kai-Kei Miu, Peter P Fu

Front Pharmacol· March 2022

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Novel Insights into Pyrrolizidine Alkaloid Toxicity and Implications for Risk Assessment: Occurrence, Genotoxicity, Toxicokinetics, Risk Assessment-A Workshop Report.
Dieter Schrenk, Jörg Fahrer, Ashley Allemang, Peter Fu, Ge Lin, Stefan Pfuhler

Planta Med· February 2022

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Developing urinary pyrrole-amino acid adducts as non-invasive biomarkers for identifying pyrrolizidine alkaloids-induced liver injury in human.
Lin Zhu, Chunyuan Zhang, Wei Zhang, Qingsu Xia, Jiang Ma, Peter P Fu

Arch Toxicol· October 2021

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Effects of glutathione and cysteine on pyrrolizidine alkaloid-induced hepatotoxicity and DNA adduct formation in rat primary hepatocytes.
Xiaobo He, Qingsu Xia, Qiang Shi, Peter P Fu

J Environ Sci Health C Toxicol Carcinog· September 2021

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Pulmonary toxicity is a common phenomenon of toxic pyrrolizidine alkaloids.
Zijing Song, Yisheng He, Jiang Ma, Peter P Fu, Ge Lin

J Environ Sci Health C Toxicol Carcinog· September 2021

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Applications of electron spin resonance spectroscopy in photoinduced nanomaterial charge separation and reactive oxygen species generation.
Xiumei Jiang, Mary D Boudreau, Peter P Fu, Jun-Jie Yin

J Environ Sci Health C Toxicol Carcinog· September 2021

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Tu-San-Qi (Gynura japonica): the culprit behind pyrrolizidine alkaloid-induced liver injury in China.
Lin Zhu, Chun-Yuan Zhang, Dong-Ping Li, Hu-Biao Chen, Jiang Ma, Peter P Fu

Acta Pharmacol Sin· August 2021

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Metabolism of carcinogenic pyrrolizidine alkaloids and pyrrolizidine alkaloid -oxides by rat primary hepatocytes generate the same characteristic DHP-DNA adducts.
Xiaobo He, Qingsu Xia, Qiang Shi, Peter P Fu

J Environ Sci Health C Toxicol Carcinog· August 2021

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Mutational Signature Analysis Reveals Widespread Contribution of Pyrrolizidine Alkaloid Exposure to Human Liver Cancer.
Yisheng He, Mai Shi, Xu Wu, Jiang Ma, Kevin Tak-Pan Ng, Peter Pi-Cheng Fu

Hepatology· July 2021

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Machine Learning for Predicting Risk of Drug-Induced Autoimmune Diseases by Structural Alerts and Daily Dose.
Yue Wu, Jieqiang Zhu, Peter Fu, Weida Tong, Huixiao Hong

Int J Environ Res Public Health· July 2021

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Correction to "1-Formyl-7-hydroxy-6,7-dihydro-5-pyrrolizine (1-CHO-DHP): A Potential Proximate Carcinogenic Metabolite of Pyrrolizidine Alkaloids".
Xiaobo He, Qingsu Xia, Gonçalo Gamboa da Costa, Ge Lin, Peter P Fu

Chem Res Toxicol· March 2021

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Comprehensive investigation and risk study on pyrrolizidine alkaloid contamination in Chinese retail honey.
Yisheng He, Lin Zhu, Jiang Ma, Lailai Wong, Zhongzhen Zhao, Peter P Fu

Environ Pollut· December 2020

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1-Formyl-7-hydroxy-6,7-dihydro-5-pyrrolizine (1-CHO-DHP)-Cysteine Conjugates: Metabolic Formation and Binding to Cellular DNA.
Xiaobo He, Qingsu Xia, Yuewei Zhao, Peter P Fu

Chem Res Toxicol· August 2020

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Separation of charge carriers and generation of reactive oxygen species by TiO nanoparticles mixed with differently-coated gold nanorods under light irradiation.
Hui Zhang, Dejing Meng, Bing Fu, Huizhen Fan, Rui Cai, Peter P Fu

J Environ Sci Health C Environ Carcinog Ecotoxicol Rev· March 2020

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Influences of simulated gastrointestinal environment on physicochemical properties of gold nanoparticles and their implications on intestinal epithelial permeability.
Xiumei Jiang, Xiaowei Zhang, Patrick Gray, Jiwen Zheng, Timothy R Croley, Peter P Fu

J Environ Sci Health C Environ Carcinog Ecotoxicol Rev· March 2020

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Quantitation of DNA reactive pyrrolic metabolites of senecionine - A carcinogenic pyrrolizidine alkaloid by LC/MS/MS analysis.
Qingsu Xia, Xiaobo He, Qiang Shi, Ge Lin, Peter P Fu

J Food Drug Anal· January 2020

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Intestinal and hepatic biotransformation of pyrrolizidine alkaloid N-oxides to toxic pyrrolizidine alkaloids.
Mengbi Yang, Jiang Ma, Jianqing Ruan, Yang Ye, Peter Pi-Cheng Fu

Arch Toxicol· August 2019

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Pyrrole-Hemoglobin Adducts, a More Feasible Potential Biomarker of Pyrrolizidine Alkaloid Exposure.
Jiang Ma, Jianqing Ruan, Xinmeng Chen, Dongping Li, Sheng Yao, Peter P Fu

Chem Res Toxicol· June 2019

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1-Formyl-7-hydroxy-6,7-dihydro-5 H-pyrrolizine (1-CHO-DHP): A Potential Proximate Carcinogenic Metabolite of Pyrrolizidine Alkaloids.
Xiaobo He, Qingsu Xia, Gonçalo Gamboa da Costa, Ge Lin, Peter P Fu

Chem Res Toxicol· June 2019

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Primary and secondary pyrrolic metabolites of pyrrolizidine alkaloids form DNA adducts in human A549 cells.
Xiaobo He, Qingsu Xia, Qiangen Wu, William H Tolleson, Ge Lin, Peter P Fu

Toxicol In Vitro· February 2019

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The role of formation of pyrrole-ATP synthase subunit beta adduct in pyrrolizidine alkaloid-induced hepatotoxicity.
Yao Lu, Jiang Ma, Zijing Song, Yang Ye, Peter P Fu

Arch Toxicol· November 2018

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