Publications by authors named "Peter Gorycki"

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Cyanide Trapping of Iminium Ion Reactive Metabolites: Implications for Clinical Hepatotoxicity.
Xiusheng Miao, Gordon J Dear, Claire Beaumont, Giovanni Vitulli, Gary Collins, Peter D Gorycki

Chem Res Toxicol· May 2024

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In vivo biodistribution and pharmacokinetics of sotrovimab, a SARS-CoV-2 monoclonal antibody, in healthy cynomolgus monkeys.
Tolulope A Aweda, Shih-Hsun Cheng, Stephen C Lenhard, Armin Sepp, Tinamarie Skedzielewski, Peter Gorycki

Eur J Nucl Med Mol Imaging· February 2023

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Pharmacokinetics, metabolism and excretion of radiolabeled fostemsavir administered with or without ritonavir in healthy male subjects.
Peter Gorycki, Mindy Magee, Peter Ackerman, Xiusheng Miao, Katy Moore

Xenobiotica· June 2022

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First-in-Human Study for a Selective Rearranged During Transfection Tyrosine Kinase Inhibitor, GSK3352589, to Investigate the Safety, Tolerability, and Pharmacokinetics in Healthy Volunteers.
Beth Ann Reedy, Robin O'Connor-Semmes, Kimberley Hacquoil, Peter Gorycki, Adeline Verticelli

Clin Pharmacol Drug Dev· April 2021

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Bioactivation of herbal constituents: mechanisms and toxicological relevance.
Bo Wen, Peter Gorycki

Drug Metab Rev· November 2019

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First-in-Human Studies for a Selective RET Tyrosine Kinase Inhibitor, GSK3179106, to Investigate the Safety, Tolerability, and Pharmacokinetics in Healthy Volunteers.
Melisa Cooper, Robin O'Connor-Semmes, Beth Ann Reedy, Kimberley Hacquoil, Peter Gorycki

Clin Pharmacol Drug Dev· February 2019

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Investigation of metabolism and disposition of GSK1322322, a peptidase deformylase inhibitor, in healthy humans using the entero-test for biliary sampling.
Donna Mamaril-Fishman, John Zhu, Min Lin, Clive Felgate, Lori Jones, Peter D Gorycki

Drug Metab Dispos· August 2014

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Metabolism and disposition of oral dabrafenib in cancer patients: proposed participation of aryl nitrogen in carbon-carbon bond cleavage via decarboxylation following enzymatic oxidation.
David A Bershas, Daniele Ouellet, Donna B Mamaril-Fishman, Noelia Nebot, Stanley W Carson, Peter D Gorycki

Drug Metab Dispos· December 2013

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Bioavailability, metabolism and disposition of oral pazopanib in patients with advanced cancer.
Yanli Deng, Caroline Sychterz, A Benjamin Suttle, Mohammed M Dar, David Bershas, Peter D Gorycki

Xenobiotica· May 2013

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Metabolism of [(14)C]GSK977779 in rats and its implication with the observed covalent binding.
Catherine D Tsalta, Armina Madatian, Ernest M Schubert, Fangming Xia, William M Hardesty, Peter D Gorycki

Drug Metab Dispos· September 2011

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Metabolism and disposition of eltrombopag, an oral, nonpeptide thrombopoietin receptor agonist, in healthy human subjects.
Yanli Deng, Armina Madatian, Mary Beth Wire, Carolyn Bowen, Jung Wook Park, Frances Gorycki, Peter D Gorycki

Drug Metab Dispos· September 2011

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Investigations of hydrazine cleavage of eltrombopag in humans.
Yanli Deng, Martin Rogers, Caroline Sychterz, Kimberly Talley, Yanwen Qian, Peter D Gorycki

Drug Metab Dispos· September 2011

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Comparison of N,N'-diarylsquaramides and N,N'-diarylureas as antagonists of the CXCR2 chemokine receptor.
Brent W McCleland, Roderick S Davis, Michael R Palovich, Katherine L Widdowson, Michelle L Werner, Peter D Gorycki

Bioorg Med Chem Lett· March 2007

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Discovery of potent and orally bioavailable N,N'-diarylurea antagonists for the CXCR2 chemokine receptor.
Qi Jin, Hong Nie, Brent W McCleland, Katherine L Widdowson, Michael R Palovich, Peter D Gorycki

Bioorg Med Chem Lett· September 2004

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An azepanone-based inhibitor of human cathepsin K with improved oral bioavailability in the rat and the monkey.
Robert W Marquis, Keith W Ward, Theresa Roethke, Brian R Smith, Yu Ru, Peter D Gorycki

Mol Pharm· January 2004

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