Publications by authors named "Peter R Sinclair"

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Arsenic decreases RXRα-dependent transcription of CYP3A and suppresses immune regulators in hepatocytes.
Trisha L Noreault-Conti, Abigail Fellows, Judith M Jacobs, Heidi W Trask, Stephen C Strom, Peter R Sinclair, Jacqueline F Sinclair

Int Immunopharmacol· April 2012

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Cytochrome P450 regulation: the interplay between its heme and apoprotein moieties in synthesis, assembly, repair, and disposal.
Maria Almira Correia, Peter R Sinclair, Francesco De Matteis

Drug Metab Rev· February 2011

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Heme-a, the heme prosthetic group of cytochrome c oxidase, is increased in Alzheimer's disease.
Barney E Dwyer, Meghan L Stone, Nadia Gorman, Peter R Sinclair, George Perry

Neurosci Lett· September 2009

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Effect of an oral iron chelator or iron-deficient diets on uroporphyria in a murine model of porphyria cutanea tarda.
Nadia Gorman, Adrian Zaharia, Heidi S Trask, Juliana G Szakacs, Nicholas J Jacobs, Jacqueline F Sinclair, Peter R Sinclair

Hepatology· December 2007

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Role of CYP3A and CYP2E1 in alcohol-mediated increases in acetaminophen hepatotoxicity: comparison of wild-type and Cyp2e1(-/-) mice.
Kristina K Wolf, Sheryl G Wood, Jenna L Allard, Jane A Hunt, Nadia Gorman, Peter R Sinclair, Jacqueline F Sinclair

Drug Metab Dispos· July 2007

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Hexachlorobenzene stimulates uroporphyria in low affinity AHR mice without increasing CYP1A2.
Nadia Gorman, Heidi S Trask, Susan W Robinson, Jacqueline F Sinclair, Glenn S Gerhard, Peter R Sinclair

Toxicol Appl Pharmacol· June 2007

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Effect of iron and ascorbate on uroporphyria in ascorbate-requiring mice as a model for porphyria cutanea tarda.
Nadia Gorman, Adrian Zaharia, Heidi S Trask, Juliana G Szakacs, Nicholas J Jacobs, Jacqueline F Sinclair, Peter R Sinclair

Hepatology· January 2007

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Involvement of Toll-like receptor 4 in acetaminophen hepatotoxicity.
Herbert C Yohe, Kimberley A O'Hara, Jane A Hunt, Tamar J Kitzmiller, Sheryl G Wood, Peter R Sinclair, Jacqueline F Sinclair

Am J Physiol Gastrointest Liver Physiol· June 2006

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Arsenite decreases CYP3A23 induction in cultured rat hepatocytes by transcriptional and translational mechanisms.
Trisha L Noreault, Judith M Jacobs, Ralph C Nichols, Heidi W Trask, Steven A Wrighton, Peter R Sinclair, Jacqueline F Sinclair

Toxicol Appl Pharmacol· December 2005

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Role of the nuclear receptor pregnane X receptor in acetaminophen hepatotoxicity.
Kristina K Wolf, Sheryl G Wood, Jane A Hunt, Brooke W Walton-Strong, Kazuto Yasuda, Peter R Sinclair, Jacqueline F Sinclair

Drug Metab Dispos· December 2005

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Mechanism of arsenite-mediated decreases in CYP3A23 in rat hepatocytes.
Trisha L Noreault, Judith M Jacobs, Ralph C Nichols, Heidi W Trask, Steven A Wrighton, Peter R Sinclair, Jacqueline F Sinclair

Biochem Biophys Res Commun· August 2005

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Arsenite decreases CYP3A4 and RXRalpha in primary human hepatocytes.
Trisha L Noreault, Vsevolod E Kostrubsky, Sheryl G Wood, Ralph C Nichols, Stephen C Strom, Peter R Sinclair, Jacqueline F Sinclair

Drug Metab Dispos· July 2005

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Effect of insulin and glucagon on accumulation of uroporphyrin and coproporphyrin from 5-aminolevulinate in hepatocyte cultures.
Heidi W Trask, Nadia Gorman, Barney E Dwyer, Nicholas J Jacobs, Judith M Jacobs, Jacqueline F Sinclair, Peter R Sinclair

Arch Biochem Biophys· July 2005

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Genetic factors influence ethanol-induced uroporphyria in Hfe(-/-) mice.
Nadia Gorman, Heidi W Trask, William J Bement, Juliana G Szakacs, George H Elder, Jacqueline F Sinclair, Peter R Sinclair

Hepatology· October 2004

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Role of mouse CYP2E1 in the O-hydroxylation of p-nitrophenol: comparison of activities in hepatic microsomes from Cyp2e1(-/-) and wild-type mice.
Kristina K Wolf, Sheryl G Wood, Jenna L Bement, Peter R Sinclair, Steven A Wrighton, Jacqueline F Sinclair

Drug Metab Dispos· July 2004

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Cyp1a1(-/-) male mice: protection against high-dose TCDD-induced lethality and wasting syndrome, and resistance to intrahepatocyte lipid accumulation and uroporphyria.
Shigeyuki Uno, Timothy P Dalton, Peter R Sinclair, Nadia Gorman, Bin Wang

Toxicol Appl Pharmacol· May 2004

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High-throughput non-heme iron assay for animal tissues.
Martin A Grundy, Nadia Gorman, Peter R Sinclair, Michael J Chorney, Glenn S Gerhard

J Biochem Biophys Methods· May 2004

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A mechanism of oxygen sensing in yeast. Multiple oxygen-responsive steps in the heme biosynthetic pathway affect Hap1 activity.
Thomas Hon, Athena Dodd, Reinhard Dirmeier, Nadia Gorman, Peter R Sinclair

J Biol Chem· December 2003

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Uroporphyria caused by ethanol in Hfe(-/-) mice as a model for porphyria cutanea tarda.
Peter R Sinclair, Nadia Gorman, Heidi W Trask, William J Bement, Juliana G Szakacs, Jacqueline F Sinclair

Hepatology· February 2003

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Uroporphyrin accumulation in hepatoma cells expressing human or mouse CYP1A2: relation to the role of CYP1A2 in human porphyria cutanea tarda.
Ralph C Nichols, Sandra Cooper, Heidi W Trask, Nadia Gorman, Timothy P Dalton, Jacqueline F Sinclair, Peter R Sinclair

Biochem Pharmacol· February 2003

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Uroporphyria in mice: thresholds for hepatic CYP1A2 and iron.
Nadia Gorman, Kerry L Ross, Heidi S Walton, William J Bement, Juliana G Szakacs, Jacqueline F Sinclair, Peter R Sinclair

Hepatology· April 2002

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