Publications by authors named "Peter Tonge"

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Selectivity of the Time-Dependent LeuRS Inhibitor Ganfeborole Is Driven by Target Vulnerability.
Mingqian Wang, YongLe He, Siobhan A Cohen, Amanda R Strohm, Gauri Shetye, Peter J Tonge

ACS Chem Biol· December 2025

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A BRET biosensor for measuring uncompetitive engagement of PRMT5 complexes in cells.
Elisabeth M Rothweiler, Ani Michaud, Jakub Stefaniak, Usha Singh, Brynwood B Mikulsky, Peter J Tonge

Nat Commun· December 2025

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An Assessment of Kinase Selectivity, Enzyme Inhibition Kinetics and in Vitro Activity for Several Bruton Tyrosine Kinase (BTK) Inhibitors.
Ana Corrionero, Xiaohu Zhang, Patricia Alfonso, Patrick J Morris, Carleen Klumpp-Thomas, Peter J Tonge

ACS Pharmacol Transl Sci· December 2025

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Dynamics and Mechanism of Off- to On-Switching in Dreiklang a Decoupled Reversibly Switchable Fluorescent Protein.
Anam Fatima, Yongle He, Danielle Rosenberger, Gregory M Greetham, Partha Malakar, Peter J Tonge

Angew Chem Int Ed Engl· November 2025

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Identifying Modulators of the Post-Antibiotic Effect.
Alexa L Gilberti, Megan M Tu, Kenneth Rachwalski, Madeeha I Ali, Siobhan A Cohen, Peter J Tonge

ACS Infect Dis· September 2025

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Ultrafast photophysics of a positive reversibly switchable fluorescent protein.
Anam Fatima, YongLe He, James N Iuliano, Gregory M Greetham, Partha Malakar, Peter J Tonge

Chem Sci· September 2025

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Modulating the Binding Kinetics of Bruton's Tyrosine Kinase Inhibitors through Transition-State Effects.
Eduardo Bravo, Yong Li, David Yin-Wei Lin, Bharath Srinivasan, Marco Barone, Peter J Tonge

J Am Chem Soc· August 2025

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Light-Driven Enzyme Catalysis: Ultrafast Mechanisms and Biochemical Implications.
YongLe He, Marco Barone, Stephen R Meech, Andras Lukacs, Peter J Tonge

Biochemistry· June 2025

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Time-Dependent Inhibition of Leucyl-tRNA-Synthetase (LeuRS): Insight into Target Vulnerability.
Mingqian Wang, YongLe He, Siobhan A Cohen, Amanda R Strohm, John D Haley, Peter J Tonge

ACS Infect Dis· April 2025

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A call to action for deciphering genetic variants in human pluripotent stem cells for cell therapy.
Nissim Benvenisty, Jonathan S Draper, Paul J Gokhale, Lyn Healy, Zoe Hewitt, Peter D Tonge

Cell Stem Cell· April 2025

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Probing the Signal Transduction Mechanism of the Light-Activated Adenylate Cyclase OaPAC Using Unnatural Amino Acid Mutagenesis.
Samruddhi S Jewlikar, Jinnette Tolentino Collado, Madeeha I Ali, Aya Sabbah, YongLe He, Peter J Tonge

ACS Chem Biol· February 2025

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Enhancing Proton-Coupled Electron Transfer in Blue Light Using FAD Photoreceptor AppA.
YongLe He, Agnieszka A Gil, Sergey P Laptenok, Anam Fatima, Jinnette Tolentino Collado, Peter J Tonge

J Am Chem Soc· January 2025

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Preclinical Positron Emission Tomography (PET) of Prosthetic Joint Infection Using a Nitro-Prodrug of 2-[F]F--Aminobenzoic Acid ([F]F-PABA).
Alyssa C Pollard-Kerning, Kaixuan Li, Yong Li, Shin Hye Ahn, Mingqian Wang, Peter J Tonge

ACS Infect Dis· November 2024

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Ready-to-use iPSC-derived microglia progenitors for the treatment of CNS disease in mouse models of neuropathic mucopolysaccharidoses.
Panagiotis Douvaras, Diego F Buenaventura, Bruce Sun, Ashley Lepack, Elizabeth Baker, Peter Tonge

Nat Commun· September 2024

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Biological Evaluation of d-[F]Fluoroalanine and d-[F]Fluoroalanine- as Positron Emission Tomography Imaging Tracers for Bacterial Infection.
Kaixuan Li, Jinnette Tolentino Collado, Jocelyn A Marden, Alyssa C Pollard, Shuwen Guo, Peter J Tonge

J Med Chem· August 2024

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Synthesis and Biological Evaluation of Fluorine-18 and Deuterium Labeled l-Fluoroalanines as Positron Emission Tomography Imaging Agents for Cancer Detection.
Kaixuan Li, Alexa L Gilberti, Jocelyn A Marden, Hari K Akula, Alyssa C Pollard, Peter J Tonge

J Med Chem· June 2024

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Single Amino Acid Mutation Decouples Photochemistry of the BLUF Domain from the Enzymatic Function of OaPAC and Drives the Enzyme to a Switched-on State.
Jinnette Tolentino Collado, Emoke Bodis, Jonatan Pasitka, Mihaly Szucs, Zsuzsanna Fekete, Peter J Tonge

J Mol Biol· March 2024

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Elucidating the Signal Transduction Mechanism of the Blue-Light-Regulated Photoreceptor YtvA: From Photoactivation to Downstream Regulation.
YongLe He, Jinnette Tolentino Collado, James N Iuliano, Helena A Woroniecka, Christopher R Hall, Peter J Tonge

ACS Chem Biol· March 2024

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Neutral ceramidase-active site inhibitor chemotypes and binding modes.
Nicolas Coant, John D Bickel, Ronald Rahaim, Yuka Otsuka, Yong-Mi Choi, Peter J Tonge

Bioorg Chem· October 2023

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Photocycle alteration and increased enzymatic activity in genetically modified photoactivated adenylate cyclase OaPAC.
Katalin Raics, Katalin Pirisi, Bo Zhuang, Zsuzsanna Fekete, Nikolett Kis-Bicskei, Peter J Tonge

J Biol Chem· August 2023

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Discovery of Novel Bruton's Tyrosine Kinase PROTACs with Enhanced Selectivity and Cellular Efficacy.
Yi-Qian Li, William G Lannigan, Shabnam Davoodi, Fereidoon Daryaee, Ana Corrionero, Peter J Tonge

J Med Chem· June 2023

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Evaluating the Impact of the Tyr158 p on the Mechanism and Inhibition of InhA, the Enoyl-ACP Reductase from .
Shabnam Davoodi, Fereidoon Daryaee, James N Iuliano, Jinnette Tolentino Collado, YongLe He, Peter J Tonge

Biochemistry· June 2023

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High Accuracy Prediction of PROTAC Complex Structures.
Mikhail Ignatov, Akhil Jindal, Sergei Kotelnikov, Dmitri Beglov, Ganna Posternak, Peter J Tonge

J Am Chem Soc· April 2023

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Synthesis and Preclinical Evaluation of a Novel Fluorine-18-Labeled Tracer for Positron Emission Tomography Imaging of Bruton's Tyrosine Kinase.
Kaixuan Li, Mingqian Wang, Melike Akoglu, Alyssa C Pollard, John B Klecker, Peter J Tonge

ACS Pharmacol Transl Sci· March 2023

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Heterobivalent Inhibitors of Acetyl-CoA Carboxylase: Drug Target Residence Time and Time-Dependent Antibacterial Activity.
Matthew T Cifone, YongLe He, Rajeswari Basu, Nan Wang, Shabnam Davoodi, Peter J Tonge

J Med Chem· December 2022

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