Publications by authors named "Philipp Hadwiger"

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Treatment of the metabolic syndrome by siRNA targeting apolipoprotein CIII.
Patricia Recio-López, Ismael Valladolid-Acebes, Philipp Hadwiger, Markus Hossbach, Monika Krampert

Biofactors· January 2023

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Ligand Conjugated Multimeric siRNAs Enable Enhanced Uptake and Multiplexed Gene Silencing.
Jonathan M Brown, James E Dahlman, Kristin K Neuman, Carla A H Prata, Monika C Krampert, Philipp M Hadwiger

Nucleic Acid Ther· October 2019

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Monitoring integrity and localization of modified single-stranded RNA oligonucleotides using ultrasensitive fluorescence methods.
Philipp Heissig, Waldemar Schrimpf, Philipp Hadwiger, Ernst Wagner, Don C Lamb

PLoS One· August 2017

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DNA as Tunable Adaptor for siRNA Polyplex Stabilization and Functionalization.
Philipp Heissig, Philipp M Klein, Philipp Hadwiger, Ernst Wagner

Mol Ther Nucleic Acids· March 2016

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Hepatocyte-targeted RNAi therapeutics for the treatment of chronic hepatitis B virus infection.
Christine I Wooddell, David B Rozema, Markus Hossbach, Matthias John, Holly L Hamilton, Philipp Hadwiger

Mol Ther· May 2013

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Structure-activity relationships of siRNA carriers based on sequence-defined oligo (ethane amino) amides.
Thomas Fröhlich, Daniel Edinger, Raphaela Kläger, Christina Troiber, Edith Salcher, Philipp Hadwiger

J Control Release· June 2012

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Nanosized multifunctional polyplexes for receptor-mediated siRNA delivery.
Christian Dohmen, Daniel Edinger, Thomas Fröhlich, Laura Schreiner, Ulrich Lächelt, Philipp Hadwiger

ACS Nano· June 2012

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Defined Folate-PEG-siRNA Conjugates for Receptor-specific Gene Silencing.
Christian Dohmen, Thomas Fröhlich, Ulrich Lächelt, Ingo Röhl, Hans-Peter Vornlocher, Philipp Hadwiger

Mol Ther Nucleic Acids· January 2012

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Purification of small interfering RNA using nondenaturing anion-exchange chromatography.
Bernhard Noll, Stephan Seiffert, Frank Hertel, Harald Debelak, Philipp Hadwiger

Nucleic Acid Ther· December 2011

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Solid-phase synthesis of sequence-defined T-, i-, and U-shape polymers for pDNA and siRNA delivery.
David Schaffert, Christina Troiber, Eveline E Salcher, Thomas Fröhlich, Irene Martin, Philipp Hadwiger

Angew Chem Int Ed Engl· September 2011

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Characterization of side reactions during the annealing of small interfering RNAs.
Stephan Seiffert, Harald Debelak, Philipp Hadwiger, Kerstin Jahn-Hofmann, Ingo Roehl

Anal Biochem· July 2011

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Unique gene-silencing and structural properties of 2'-fluoro-modified siRNAs.
Muthiah Manoharan, Akin Akinc, Rajendra K Pandey, June Qin, Philipp Hadwiger

Angew Chem Int Ed Engl· March 2011

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Modulation of thermal stability can enhance the potency of siRNA.
Haripriya Addepalli, Meena, Chang G Peng, Gang Wang, Yupeng Fan, Philipp Hadwiger

Nucleic Acids Res· November 2010

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Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma.
Maria-del-Mar Inda, Rudy Bonavia, Akitake Mukasa, Yoshitaka Narita, Dinah W Y Sah, Philipp Hadwiger

Genes Dev· August 2010

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Polyethylenimine/small interfering RNA-mediated knockdown of vascular endothelial growth factor in vivo exerts anti-tumor effects synergistically with Bevacizumab.
Sabrina Höbel, Ivette Koburger, Matthias John, Frank Czubayko, Philipp Hadwiger

J Gene Med· March 2010

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RNA interference-mediated silencing of the respiratory syncytial virus nucleocapsid defines a potent antiviral strategy.
Rene Alvarez, Sayda Elbashir, Todd Borland, Ivanka Toudjarska, Philipp Hadwiger

Antimicrob Agents Chemother· September 2009

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FAPP2 gene downregulation increases tumor cell sensitivity to Fas-induced apoptosis.
Richard Tritz, Michelle J Hickey, Amy H Lin, Philipp Hadwiger, Dinah W Y Sah

Biochem Biophys Res Commun· May 2009

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Host scavenger receptor SR-BI plays a dual role in the establishment of malaria parasite liver infection.
Cristina D Rodrigues, Michael Hannus, Miguel Prudêncio, Cécilie Martin, Lígia A Gonçalves, Philipp Hadwiger

Cell Host Microbe· September 2008

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Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates.
Maria Frank-Kamenetsky, Aldo Grefhorst, Norma N Anderson, Timothy S Racie, Birgit Bramlage, Philipp Hadwiger

Proc Natl Acad Sci U S A· August 2008

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siRNA knock-down of mutant torsinA restores processing through secretory pathway in DYT1 dystonia cells.
Jeffrey W Hewett, Flávia C Nery, Brian Niland, Pei Ge, Pamela Tan, Philipp Hadwiger

Hum Mol Genet· May 2008

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siRNA Down-regulation of the PATZ1 Gene in Human Glioma Cells Increases Their Sensitivity to Apoptotic Stimuli.
Richard Tritz, Barbara M Mueller, Michelle J Hickey, Amy H Lin, German G Gomez, Philipp Hadwiger

Cancer Ther· January 2008

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Effective RNAi-mediated gene silencing without interruption of the endogenous microRNA pathway.
Matthias John, Rainer Constien, Akin Akinc, Michael Goldberg, Young-Ah Moon, Philipp Hadwiger

Nature· October 2007

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Targeting MLL-AF4 with short interfering RNAs inhibits clonogenicity and engraftment of t(4;11)-positive human leukemic cells.
Maria Thomas, Andreas Gessner, Hans-Peter Vornlocher, Philipp Hadwiger, Johann Greil

Blood· November 2005

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Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs.
Jürgen Soutschek, Akin Akinc, Birgit Bramlage, Klaus Charisse, Rainer Constien, Philipp Hadwiger

Nature· November 2004

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Gene silencing by RNAi in mammalian cells.
Matthias John, Anke Geick, Philipp Hadwiger, Hans-Peter Vornlocher, Olaf Heidenreich

Curr Protoc Mol Biol· May 2003

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