Publications by authors named "Philippe Juin"

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Allosteric regulation of BH3-in-groove interactions by tail anchors of BCL-xL complexes limits BH3 mimetic antagonism.
Laurent Maillet, Aurélie Fétiveau, Lisenn Lalier, Nena Martin, Sophie Barillé-Nion, Philippe Paul Juin

Nat Commun· November 2025

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EMT-ciliary signaling in quasi-mesenchymal-stem-like cells drives therapeutic resistance and is a druggable vulnerability in triple-negative breast cancer.
Camille E Tessier, Jennifer Derrien, Aurore M M Dupuy, Thomas Pelé, Martin Moquet, Philippe P Juin

EMBO Mol Med· October 2025

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MCL-1 as a molecular switch between myofibroblastic and pro-angiogenic features of breast cancer-associated fibroblasts.
Chloé C Lefebvre, Philippine Giowachini, Jennifer Derrien, Maxime Naour, Isabelle Corre, Philippe P Juin

Cell Death Dis· August 2025

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A Rac-specific competitive inhibitor of guanine nucleotide binding reduces metastasis in triple-negative breast cancer.
Florian Dilasser, Lindsay Rose, Agnès Quemener, Yann Ferrandez, Dorian Hassoun, Philippe Juin

Cell Rep Med· July 2025

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CRCINA inaugural symposium: A meeting on tumor and immune ecosystems.
Vincent J Guen, Gwennan André-Grégoire, Céline Beauvillain, Frank Boury, Morgane Chauvet, Philippe P Juin

Biol Cell· December 2024

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Mesenchymal-like immune-altered is the fourth robust triple-negative breast cancer molecular subtype.
Pascal Jézéquel, Hamza Lasla, Wilfried Gouraud, Agnès Basseville, Bertrand Michel, Philippe P Juin

Breast Cancer· September 2024

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Low BCL-xL expression in triple-negative breast cancer cells favors chemotherapy efficacy, and this effect is limited by cancer-associated fibroblasts.
Lisa Nocquet, Julie Roul, Chloé C Lefebvre, Laurine Duarte, Mario Campone, Philippe P Juin

Sci Rep· June 2024

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Stress in the metastatic journey - the role of cell communication and clustering in breast cancer progression and treatment resistance.
Eloïse M Grasset, Sophie Barillé-Nion, Philippe P Juin

Dis Model Mech· March 2024

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EMT and primary ciliogenesis: For better or worse in sickness and in health.
Camille E Tessier, Aurore M M Dupuy, Thomas Pelé, Philippe P Juin, Jacqueline A Lees

Genesis· February 2024

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ChemR23 activation reprograms macrophages toward a less inflammatory phenotype and dampens carcinoma progression.
Margot Lavy, Vanessa Gauttier, Alison Dumont, Florian Chocteau, Sophie Deshayes, Philippe Juin

Front Immunol· August 2023

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Using mammary organoids to study cilia.
Aurore M M Dupuy, Philippe P Juin, Vincent J Guen

Methods Cell Biol· March 2023

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Targeting of MCL-1 in breast cancer-associated fibroblasts reverses their myofibroblastic phenotype and pro-invasive properties.
Thomas L Bonneaud, Chloé C Lefebvre, Lisa Nocquet, Agnes Basseville, Julie Roul, Philippe P Juin

Cell Death Dis· September 2022

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Keeping Cell Death Alive: An Introduction into the French Cell Death Research Network.
Gabriel Ichim, Benjamin Gibert, Sahil Adriouch, Catherine Brenner, Nathalie Davoust, Philippe P Juin

Biomolecules· June 2022

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[Interest of the bc-GenExMiner web tool in oncology].
Pascal Jézéquel, Wilfried Gouraud, Fadoua Ben Azzouz, Agnès Basseville, Philippe P Juin

Bull Cancer· November 2021

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Synthesis and biological studies of new piperidino-1,2,3-triazole hybrids with 3-aryl isoxazole side chains.
Appala Venkata Ramana Murthy, Vennu Narendar, Nangunoori Sampath Kumar, Pasula Aparna, Anagani Kanaka Durga Bhavani, Philippe Juin

Bioorg Med Chem Lett· November 2021

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An EMT-primary cilium-GLIS2 signaling axis regulates mammogenesis and claudin-low breast tumorigenesis.
Molly M Wilson, Céline Callens, Matthieu Le Gallo, Svetlana Mironov, Qiong Ding, Philippe P Juin

Sci Adv· October 2021

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Random forest of perfect trees: concept, performance, applications and perspectives.
Jean-Michel Nguyen, Pascal Jézéquel, Pierre Gillois, Luisa Silva, Faouda Ben Azzouz, Philippe Juin

Bioinformatics· August 2021

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Development of an absolute assignment predictor for triple-negative breast cancer subtyping using machine learning approaches.
Fadoua Ben Azzouz, Bertrand Michel, Hamza Lasla, Wilfried Gouraud, Anne-Flore François, Philippe P Juin

Comput Biol Med· February 2021

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bc-GenExMiner 4.5: new mining module computes breast cancer differential gene expression analyses.
Pascal Jézéquel, Wilfried Gouraud, Fadoua Ben Azzouz, Catherine Guérin-Charbonnel, Philippe P Juin

Database (Oxford)· February 2021

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Mitochondria at Center of Exchanges between Cancer Cells and Cancer-Associated Fibroblasts during Tumor Progression.
Lisa Nocquet, Philippe P Juin, Frédérique Souazé

Cancers (Basel)· October 2020

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RE: Immune Checkpoint Profiles in Luminal B Breast Cancer (Alliance).
Pascal Jézéquel, Anne Patsouris, Catherine Guette, Philippe P Juin, Mario Campone

J Natl Cancer Inst· August 2020

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Targeting of BCL-2 Family Members during Anticancer Treatment: A Necessary Compromise between Individual Cell and Ecosystemic Responses?
Sophie Barillé-Nion, Steven Lohard, Philippe P Juin

Biomolecules· July 2020

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Mitotic stress-induced secretome primes cancer cells to apoptosis and maximizes paclitaxel response in breast tumors when combined with BCL-xL-targeting BH3 mimetics.
Steven Lohard, Philippe P Juin, Sophie Barillé-Nion

Mol Cell Oncol· March 2020

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STING-dependent paracriny shapes apoptotic priming of breast tumors in response to anti-mitotic treatment.
Steven Lohard, Nathalie Bourgeois, Laurent Maillet, Fabien Gautier, Aurélie Fétiveau, Philippe P Juin

Nat Commun· January 2020

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Targeting PUMA/Bcl-xL interaction by new specific compounds to unleash apoptotic process in cancer cells.
Appala Venkata Ramana Murthy, Vennu Narendar, Nangunoori Sampath Kumar, Pasula Aparna, Anagani Kanaka Durga Bhavani, Philippe Juin

Eur J Med Chem· January 2019

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