Publications by authors named "Philippe Urban"

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Redox partner exchanges between spatially confined complexes control the coupling effect of cytochrome b on P450 CYP3A4.
Philippe Urban, Alain Perret, Denis Pompon

Sci Rep· July 2025

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Expanding the Diversity of Nitroxide-Based Paramagnetic Probes Conjugated to Non-Canonical Amino Acids for Sdsl-Epr Applications.
Maxime Bizet, Áron Balázsi, Frédéric Biaso, Deborah Byrne, Emilien Etienne, Philippe Urban

Chembiochem· April 2025

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Geometry-encoded molecular dynamics enables deep learning insights into P450 regiospecificity control.
Denis Pompon, Luis F Garcia-Alles, Philippe Urban

Sci Rep· March 2025

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Structural insights into the semiquinone form of human Cytochrome P450 reductase by DEER distance measurements between a native flavin and a spin labelled non-canonical amino acid.
Maxime Bizet, Deborah Byrne, Frédéric Biaso, Guillaume Gerbaud, Emilien Etienne, Philippe Urban

Chemistry· April 2024

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Single Mutations in Cytochrome P450 Oxidoreductase Can Alter the Specificity of Human Cytochrome P450 1A2-Mediated Caffeine Metabolism.
Francisco Esteves, Cristina M M Almeida, Sofia Silva, Inês Saldanha, Philippe Urban

Biomolecules· July 2023

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Confrontation of AlphaFold models with experimental structures enlightens conformational dynamics supporting CYP102A1 functions.
Philippe Urban, Denis Pompon

Sci Rep· September 2022

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Interaction Modes of Microsomal Cytochrome P450s with Its Reductase and the Role of Substrate Binding.
Francisco Esteves, Philippe Urban, José Rueff, Gilles Truan, Michel Kranendonk

Int J Mol Sci· September 2020

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Corrigendum: The Role of the FMN-Domain of Human Cytochrome P450 Oxidoreductase in Its Promiscuous Interactions With Structurally Diverse Redox Partners.
Francisco Esteves, Diana Campelo, Bruno Costa Gomes, Philippe Urban, Sophie Bozonnet

Front Pharmacol· May 2020

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The Role of the FMN-Domain of Human Cytochrome P450 Oxidoreductase in Its Promiscuous Interactions With Structurally Diverse Redox Partners.
Francisco Esteves, Diana Campelo, Bruno Costa Gomes, Philippe Urban, Sophie Bozonnet

Front Pharmacol· March 2020

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Development of a Biosensor for Detection of Benzoic Acid Derivatives in .
Sara Castaño-Cerezo, Mathieu Fournié, Philippe Urban, Jean-Loup Faulon, Gilles Truan

Front Bioeng Biotechnol· January 2020

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Human cytochrome P450 expression in bacteria: Whole-cell high-throughput activity assay for CYP1A2, 2A6 and 3A4.
Francisco Esteves, Diana Campelo, Philippe Urban, Sophie Bozonnet, Thomas Lautier

Biochem Pharmacol· December 2018

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Probing the Role of the Hinge Segment of Cytochrome P450 Oxidoreductase in the Interaction with Cytochrome P450.
Diana Campelo, Francisco Esteves, Bernardo Brito Palma, Bruno Costa Gomes, José Rueff, Philippe Urban

Int J Mol Sci· December 2018

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Ligand Access Channels in Cytochrome P450 Enzymes: A Review.
Philippe Urban, Thomas Lautier, Denis Pompon, Gilles Truan

Int J Mol Sci· May 2018

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Correction: The Hinge Segment of Human NADPH-Cytochrome P450 Reductase in Conformational Switching: The Critical Role of Ionic Strength.
Diana Campelo, Thomas Lautier, Philippe Urban, Francisco Esteves, Sophie Bozonnet

Front Pharmacol· March 2018

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The Hinge Segment of Human NADPH-Cytochrome P450 Reductase in Conformational Switching: The Critical Role of Ionic Strength.
Diana Campelo, Thomas Lautier, Philippe Urban, Francisco Esteves, Sophie Bozonnet

Front Pharmacol· October 2017

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Cytochrome P450 expression system for high-throughput real-time detection of genotoxicity: Application to the study of human CYP1A2 variants.
Bernardo Brito Palma, Daniela Moutinho, Philippe Urban, José Rueff, Michel Kranendonk

Mutat Res Genet Toxicol Environ Mutagen· August 2016

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Ordered chimerogenesis applied to CYP2B P450 enzymes.
Thomas Lautier, Philippe Urban, Jacqueline Loeper, Laetitia Jezequel, Denis Pompon

Biochim Biophys Acta· July 2016

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Functional characterization of zebrafish cytochrome P450 1 family proteins expressed in yeast.
John J Stegeman, Lars Behrendt, Bruce R Woodin, Akira Kubota, Benjamin Lemaire, Philippe Urban

Biochim Biophys Acta· November 2015

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High-throughput functional screening of steroid substrates with wild-type and chimeric P450 enzymes.
Philippe Urban, Gilles Truan, Denis Pompon

Biomed Res Int· June 2015

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Access channels to the buried active site control substrate specificity in CYP1A P450 enzymes.
Philippe Urban, Gilles Truan, Denis Pompon

Biochim Biophys Acta· April 2015

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Altered substrate specificity of the Pterygoplichthys sp. (Loricariidae) CYP1A enzyme.
Thiago E M Parente, Philippe Urban, Denis Pompon, Mauro F Rebelo

Aquat Toxicol· September 2014

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High-throughput enzymology and combinatorial mutagenesis for mining cytochrome P450 functions.
Philippe Urban, Gilles Truan, Denis Pompon

Expert Opin Drug Metab Toxicol· June 2008

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A combinatorial approach to substrate discrimination in the P450 CYP1A subfamily.
Valérie Taly, Philippe Urban, Gilles Truan, Denis Pompon

Biochim Biophys Acta· March 2007

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Inter-conversion of 7alpha- and 7beta-hydroxy-dehydroepiandrosterone by the human 11beta-hydroxysteroid dehydrogenase type 1.
Caroline Muller, Denis Pompon, Philippe Urban, Robert Morfin

J Steroid Biochem Mol Biol· June 2006

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Painful left bundle branch block detected during dobutamine stress echocardiography.
Stefano Ciaroni, Philippe Urban

J Am Soc Echocardiogr· November 2002

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