Publications by authors named "Pieter Colin"

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Evaluating Model-Based Extrapolation of Plasma Exposure for Long-Acting Injectable Products: From Single- to Multiple-Dose Trials.
D Esther Lubberts, Douglas J Eleveld, Laurens F M Verscheijden, Pieter J Colin, Jeroen V Koomen

CPT Pharmacometrics Syst Pharmacol· December 2025

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The dose-response relationship between norepinephrine dose and mean arterial pressure with and without general anaesthesia: A study in healthy volunteers.
Ilonka N de Keijzer, Johannes P van den Berg, Dario Massari, Anthony R Absalom, Dirk J Bosch, Pieter J Colin

Eur J Anaesthesiol· November 2025

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Reply to: "Current Use of PBPK Modeling in New Medicinal Product Approvals at EMA: A Clinical Appraisal of Voclosporin in Lupus Nephritis".
Polly Paul, Pieter J Colin, Flora Musuamba Tshinanu, Carolien Versantvoort, Efthymios Manolis

Clin Pharmacol Ther· September 2025

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Pharmacokinetics and Pharmacodynamics of Remimazolam for Procedural Sedation in Children and Adolescents.
Pieter J Colin, Lynn H Bichajian, Valentin R Curt, Jeroen V Koomen, Thomas Stöhr

Anesthesiology· August 2025

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Development and analysis of a remimazolam pharmacokinetics and pharmacodynamics model with proposed dosing and concentrations for anaesthesia and sedation.
Douglas J Eleveld, Pieter J Colin, Johannes P Van den Berg, Jeroen V Koomen, Thomas Stoehr

Br J Anaesth· July 2025

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A review on the role of extrapolation as basis for paediatric marketing authorization applications of medicines in the EU.
Charlotte W M Simons, Loes C H Maton, Maaike van Dartel, Michiel van den Heuvel, Loes den Otter, Pieter J Colin

Br J Clin Pharmacol· May 2025

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Influence of Remifentanil on the Pharmacokinetics and Pharmacodynamics of Remimazolam in Healthy Volunteers.
Remco Vellinga, Jeroen V Koomen, Douglas J Eleveld, Thomas Stöhr, Marija Pesic, Pieter J Colin

Anesthesiology· April 2025

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Current Use of Physiologically Based Pharmacokinetic modeling in New Medicinal Product Approvals at EMA.
Polly Paul, Pieter J Colin, Flora Musuamba Tshinanu, Carolien Versantvoort, Efthymios Manolis

Clin Pharmacol Ther· March 2025

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A Pooled Pharmacokinetic Analysis for Piperacillin/Tazobactam Across Different Patient Populations: From Premature Infants to the Elderly.
Daming Kong, Jason A Roberts, Jeffrey Lipman, Fabio Silvio Taccone, Michael Cohen-Wolkowiez, Pieter J Colin

Clin Pharmacokinet· January 2025

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EMA perspective on the value of model-informed drug development for labeling recommendations regarding medicine use during pregnancy and breastfeeding.
Efthymios Manolis, Flora Tshinanu Musuamba, Corinne S de Vries, Pieter J Colin, Martin B Oleksiewicz

CPT Pharmacometrics Syst Pharmacol· November 2024

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Population Pharmacokinetic Modelling of Norepinephrine in Healthy Volunteers Prior to and During General Anesthesia.
Yingxue Li, Jeroen V Koomen, Douglas J Eleveld, Johannes P van den Berg, Jaap Jan Vos, Pieter J Colin

Clin Pharmacokinet· November 2024

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Target-controlled Infusion of Remimazolam in Healthy Volunteers Shows Some Acute Tolerance.
Remco Vellinga, Jeroen V Koomen, Douglas J Eleveld, Thomas Stöhr, Marija Pesic, Pieter J Colin

Anesthesiology· February 2024

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Gentamicin Administration in Dialysis Patients: Before or After Hemodialysis?
Geeske F Grit, Martha L Toren-Wielema, Pieter J Colin, Daan J Touw

Ther Drug Monit· October 2023

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Development of a pharmacokinetic and pharmacodynamic model for intranasal administration of midazolam in older adults: a single-site two-period crossover study.
Clemens Barends, Izaak den Daas, Mendy Driesens, Anita Visser, Anthony Absalom, Pieter Colin

Br J Anaesth· August 2023

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A Joint Pharmacokinetic Model for the Simultaneous Description of Plasma and Whole Blood Tacrolimus Concentrations in Kidney and Lung Transplant Recipients.
Jeroen V Koomen, Tim J Knobbe, Tanja R Zijp, Daan Kremer, C Tji Gan, Pieter J Colin

Clin Pharmacokinet· August 2023

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Pharmacodynamic mechanism-based interaction model for the haemodynamic effects of remifentanil and propofol in healthy volunteers.
Hong Su, Jeroen V Koomen, Douglas J Eleveld, Michel M R F Struys, Pieter J Colin

Br J Anaesth· August 2023

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Moving Toward a Question-Centric Approach for Regulatory Decision Making in the Context of Drug Assessment.
Flora T Musuamba, S Y Amy Cheung, Pieter Colin, Elin H Davies, Jeffrey S Barret

Clin Pharmacol Ther· July 2023

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Dose assessment of melatonin in sepsis (DAMSEL2) study: Pharmacokinetics of two doses of oral melatonin in patients with sepsis.
Helen F Galley, Lee Allen, Pieter J Colin, Sally P Galt, Nigel R Webster

J Pineal Res· November 2022

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Development and evaluation of uncertainty quantifying machine learning models to predict piperacillin plasma concentrations in critically ill patients.
Jarne Verhaeghe, Sofie A M Dhaese, Thomas De Corte, David Vander Mijnsbrugge, Heleen Aardema, Pieter Colin

BMC Med Inform Decis Mak· August 2022

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Mechanism-based pharmacodynamic model for propofol haemodynamic effects in healthy volunteers.
Hong Su, Douglas J Eleveld, Michel M R F Struys, Pieter J Colin

Br J Anaesth· May 2022

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Dexmedetomidine Clearance Decreases with Increasing Drug Exposure: Implications for Current Dosing Regimens and Target-controlled Infusion Models Assuming Linear Pharmacokinetics.
Ricardo Alvarez-Jimenez, Maud A S Weerink, Laura N Hannivoort, Hong Su, Michel M R F Struys, Pieter J Colin

Anesthesiology· February 2022

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Pharmacokinetic properties of remimazolam in subjects with hepatic or renal impairment.
Thomas Stöhr, Pieter J Colin, Joachim Ossig, Marija Pesic, Keith Borkett

Br J Anaesth· September 2021

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Optimizing Amoxicillin/Clavulanic Acid Dosing Regimens in Patients on Maintenance High-Flux Hemodialysis.
Kelly De Schuyter, Pieter J Colin, Floris Vanommeslaeghe, Sigurd Delanghe, Pieter De Cock

Am J Kidney Dis· July 2021

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Clinical validation of pharmacokinetic/pharmacodynamic models for propofol infusion. Response to Br J Anaesth 2021: 126: e172-4.
Remco Vellinga, Laura N Hannivoort, Jeroen V Koomen, Pieter Colin, Anthony R Absalom

Br J Anaesth· July 2021

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Comment on Morse et al. A Universal Pharmacokinetic Model for Dexmedetomidine in Children and Adults. 2020, , 3480.
Douglas J Eleveld, Pieter J Colin, Laura N Hannivoort, Anthony R Absalom, Michel M R F Struys

J Clin Med· July 2021

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