Publications by authors named "Pilho Kim"

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Development of a TBK1 and ALK dual inhibitor for alleviating depressive behavior via anti-inflammatory effects.
Ji Hun Wi, Hyelim Lee, Ji Min Park, Yeonju Heo, Seongman Jo, Yeseul Kim, Nam-Jung Kim, Pilho Kim, Hyejin Kim

Biomed Pharmacother· May 2025

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Novel hematopoietic progenitor kinase 1 inhibitor KHK-6 enhances T-cell activation.
Min Jeong Ahn, Eun Hye Kim, Yunha Choi, Chong Hak Chae, Pilho Kim, Seong Hwan Kim

PLoS One· June 2024

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Orally bioavailable BTK PROTAC active against wild-type and C481 mutant BTKs in human lymphoma CDX mouse models.
Ye Seul Lim, Sun-Mi Yoo, Vineet Patil, Han Wool Kim, Hyun-Hwi Kim, Pilho Kim

Blood Adv· January 2023

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Structure-activity relationship analysis of novel GSPT1 degraders based on benzotriazinone scaffold and its antitumor effect on xenograft mouse model.
Akshay D Takwale, Eun Yeong Kim, Yerin Jang, Dong Ho Lee, Seulgi Kim, Jin Hwan Kim, Yeongrin Kim, Jeong-Hoon Kim, Pilho Kim

Bioorg Chem· October 2022

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DCLK1 promotes colorectal cancer stemness and aggressiveness via the XRCC5/COX2 axis.
Jee-Heun Kim, So-Yeon Park, So-El Jeon, Jang-Hyun Choi, Choong-Jae Lee, Pilho Kim

Theranostics· August 2022

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A novel cereblon modulator for targeted protein degradation.
Sung Ah Kim, Ara Go, Seung-Hyun Jo, Sun Jun Park, Young Uk Jeon, Ji Eun Kim, Pilho Kim, Sunhong Kim, Jeong-Hoon Kim

Eur J Med Chem· March 2019

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Grignard-mediated rearrangement of trifluoroacetyl from dihydroisoquinoline enamides to afford tertiary trifluoromethylcarbinols.
Raghavendra Achary, Gangadhar Rao Mathi, Seulgi Kim, Jong Yeon Hwang, Pilho Kim

Org Biomol Chem· February 2018

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Novel 2,4-diaminopyrimidines bearing fused tricyclic ring moiety for anaplastic lymphoma kinase (ALK) inhibitor.
Raghavendra Achary, Gangadhar Rao Mathi, Dong Ho Lee, Chang Soo Yun, Chong Ock Lee, Hyoung Rae Kim, Pilho Kim

Bioorg Med Chem Lett· May 2017

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Replacing the terminal piperidine in ceritinib with aliphatic amines confers activities against crizotinib-resistant mutants including G1202R.
Gangadhar Rao Mathi, Chung Hyo Kang, Heung Kyoung Lee, Raghavendra Achary, Ha-Yeon Lee, Hyoung Rae Kim, Pilho Kim

Eur J Med Chem· January 2017

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Discovery of novel tetrahydroisoquinoline-containing pyrimidines as ALK inhibitors.
Raghavendra Achary, Jeong In Yun, Chi Min Park, Gangadhar Rao Mathi, Joo Yun Lee, Hyoung Rae Kim, Pilho Kim

Bioorg Med Chem· January 2016

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Synthesis and evaluation of novel 2,4-diaminopyrimidines bearing bicyclic aminobenzazepines for anaplastic lymphoma kinase (ALK) inhibitor.
Ga Ae Kang, Minji Lee, Dawn Song, Heung Kyoung Lee, Sunjoo Ahn, Pilho Kim, Hyoung Rae Kim

Bioorg Med Chem Lett· September 2015

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Development of potent ALK inhibitor and its molecular inhibitory mechanism against NSCLC harboring EML4-ALK proteins.
Chung Hyo Kang, Jeong In Yun, Kwangho Lee, Chong Ock Lee, Heung Kyoung Lee, Pilho Kim, Hyoung Rae Kim

Biochem Biophys Res Commun· August 2015

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Novel 2,4-dianilino-5-fluoropyrimidine derivatives possessing ALK inhibitory activities.
Jeong In Yun, Eun Hye Yang, Muhammad Latif, Hyeon Ji Lee, Kwangho Lee, Pilho Kim, Hyoung Rae Kim

Arch Pharm Res· July 2014

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Synthesis and anti-influenza virus activity of 4-oxo- or thioxo-4,5-dihydrofuro[3,4-c]pyridin-3(1H)-ones.
Ye Jin Jang, Raghavendra Achary, Hye Won Lee, Hyo Jin Lee, Chong-Kyo Lee, Pilho Kim, Meehyein Kim

Antiviral Res· July 2014

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Inhibition of influenza virus internalization by (-)-epigallocatechin-3-gallate.
Meehyein Kim, So-Yeon Kim, Hye Won Lee, Jin Soo Shin, Pilho Kim

Antiviral Res· November 2013

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Novel bis-ortho-alkoxy-para-piperazinesubstituted-2,4-dianilinopyrimidines (KRCA-0008) as potent and selective ALK inhibitors for anticancer treatment.
Chi Hoon Park, Hyeonjeong Choe, In-Young Jang, So Yeong Kwon, Muhammad Latif, Hyoung Rae Kim, Pilho Kim

Bioorg Med Chem Lett· November 2013

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3D-QSAR and cell wall permeability of antitubercular nitroimidazoles against Mycobacterium tuberculosis.
Sang-Ho Lee, Minsung Choi, Pilho Kim, Pyung Keun Myung

Molecules· November 2013

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Efficient synthesis of 3H,3'H-spiro[benzofuran-2,1'-isobenzofuran]-3,3'-dione as novel skeletons specifically for influenza virus type B inhibition.
Yashwardhan Malpani, Raghavendra Achary, So Yeon Kim, Hee Chun Jeong, Pilho Kim, Meehyein Kim, Jae Nyoung Kim

Eur J Med Chem· April 2013

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Thiolactomycin-based β-ketoacyl-AcpM synthase A (KasA) inhibitors: fragment-based inhibitor discovery using transient one-dimensional nuclear overhauser effect NMR spectroscopy.
Kanishk Kapilashrami, Gopal R Bommineni, Carl A Machutta, Pilho Kim, Cheng-Tsung Lai

J Biol Chem· March 2013

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Design, synthesis, and structure-activity relationship studies of tryptanthrins as antitubercular agents.
Jae-Min Hwang, Taegwon Oh, Takushi Kaneko, Anna M Upton, Scott G Franzblau, Pilho Kim

J Nat Prod· March 2013

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Design and synthesis of 1H-1,2,3-triazoles derived from econazole as antitubercular agents.
Suhyun Kim, Sang-Nae Cho, Taegwon Oh, Pilho Kim

Bioorg Med Chem Lett· November 2012

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Synthesis and antitubercular activity of monocyclic nitroimidazoles: insights from econazole.
Sang-Ho Lee, Suhyun Kim, Min-Han Yun, Yong Sup Lee, Sang-Nae Cho, Pilho Kim

Bioorg Med Chem Lett· March 2011

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Structure-activity relationships of antitubercular nitroimidazoles. 1. Structural features associated with aerobic and anaerobic activities of 4- and 5-nitroimidazoles.
Pilho Kim, Liang Zhang, Ujjini H Manjunatha, Ramandeep Singh, Sejal Patel

J Med Chem· March 2009

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Structure-activity relationships of antitubercular nitroimidazoles. 2. Determinants of aerobic activity and quantitative structure-activity relationships.
Pilho Kim, Sunhee Kang, Helena I Boshoff, Jan Jiricek, Margaret Collins

J Med Chem· March 2009

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PA-824 kills nonreplicating Mycobacterium tuberculosis by intracellular NO release.
Ramandeep Singh, Ujjini Manjunatha, Helena I M Boshoff, Young Hwan Ha, Pornwaratt Niyomrattanakit, Pilho Kim

Science· November 2008

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