Publications by authors named "Pim Heckman"

Claim this Profile
I
Individual contribution of PDE4B and PDE4D subfamilies to the prevention of object location memory impairments induced by sleep deprivation.
Hongyu Zhao, Arjan Blokland, Jos Prickaerts, Robbert Havekes, Elroy L Meijer, Pim R A Heckman

Learn Mem· June 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
M
Memory impairments observed after a half night sleep restriction are not mediated by working memory, attention, or inhibitory control mechanisms.
Pim R A Heckman, Robbert Havekes, Arjan Blokland

Neurobiol Learn Mem· May 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
Treatment with the selective PDE4B inhibitor A-33 or PDE4D inhibitor zatolmilast prevents sleep deprivation-induced deficits in spatial pattern separation.
Hongyu Zhao, Arjan Blokland, Jos Prickaerts, Robbert Havekes, Pim R A Heckman

Behav Brain Res· February 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Acute sleep loss impairs object but not spatial pattern separation in humans.
Arjan Blokland, Meyra Jackson, Kia Puustinen, Jens Soeterboek, Pim R A Heckman

Neurosci Lett· October 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
R
Recovering object-location memories after sleep deprivation-induced amnesia.
Youri G Bolsius, Pim R A Heckman, Camilla Paraciani, Sophia Wilhelm, Frank Raven

Curr Biol· January 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Soluble guanylate cyclase stimulator riociguat improves spatial memory in mice via peripheral mechanisms.
Ellis Nelissen, Britt T J van Hagen, Elentina K Argyrousi, Nick P van Goethem, Pim R A Heckman

Neurosci Lett· September 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
A brief period of sleep deprivation negatively impacts the acquisition, consolidation, and retrieval of object-location memories.
Pim R A Heckman, Femke Roig Kuhn, Peter Meerlo, Robbert Havekes

Neurobiol Learn Mem· November 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Sleep deprivation-induced impairment of memory consolidation is not mediated by glucocorticoid stress hormones.
Frank Raven, Pim R A Heckman, Robbert Havekes, Peter Meerlo

J Sleep Res· October 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
The contribution of Parkin, PINK1 and DJ-1 genes to selective neuronal degeneration in Parkinson's disease.
Marc van der Vlag, Robbert Havekes, Pim R A Heckman

Eur J Neurosci· August 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
G
Genetic manipulation of cyclic nucleotide signaling during hippocampal neuroplasticity and memory formation.
Michy P Kelly, Pim R A Heckman, Robbert Havekes

Prog Neurobiol· July 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
R
Role of cyclic nucleotides and their downstream signaling cascades in memory function: Being at the right time at the right spot.
Elentina K Argyrousi, Pim R A Heckman, Jos Prickaerts

Neurosci Biobehav Rev· June 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Phosphodiesterase inhibitors roflumilast and vardenafil prevent sleep deprivation-induced deficits in spatial pattern separation.
Pim R A Heckman, Femke Roig Kuhn, Frank Raven, Youri G Bolsius, Jos Prickaerts

Synapse· June 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Pro-cognitive effect of upregulating cyclic guanosine monophosphate signalling during memory acquisition or early consolidation is mediated by increased AMPA receptor trafficking.
Elentina K Argyrousi, Pim Ra Heckman, Britt Tj van Hagen, Hannah Muysers, Nick P van Goethem

J Psychopharmacol· January 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Alzheimer's disease pathogenesis: The role of disturbed sleep in attenuated brain plasticity and neurodegenerative processes.
Robbert Havekes, Pim R A Heckman, Emma J Wams, Neringa Stasiukonyte, Peter Meerlo

Cell Signal· December 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Phosphodiesterase Type 4 Inhibition in CNS Diseases.
Arjan Blokland, Pim Heckman, Tim Vanmierlo, Rudy Schreiber, Dean Paes

Trends Pharmacol Sci· December 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Acute treatment with the PDE4 inhibitor roflumilast improves verbal word memory in healthy old individuals: a double-blind placebo-controlled study.
Arjan Blokland, Marlies A Van Duinen, Anke Sambeth, Pim R A Heckman, Max Tsai

Neurobiol Aging· May 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
V
Validation of the xylazine/ketamine anesthesia test as a predictor of the emetic potential of pharmacological compounds in rats.
Ellis Nelissen, Nick P van Goethem, Vivian T Bonassoli, Pim R A Heckman, Britt T J van Hagen

Neurosci Lett· April 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
F
From Age-Related Cognitive Decline to Alzheimer's Disease: A Translational Overview of the Potential Role for Phosphodiesterases.
Pim R A Heckman, Arjan Blokland, Jos Prickaerts

Adv Neurobiol· January 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Acute administration of roflumilast enhances sensory gating in healthy young humans in a randomized trial.
Pim R A Heckman, Marlies A Van Duinen, Arjan Blokland, Tolga Uz, Jos Prickaerts

Psychopharmacology (Berl)· January 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Investigational phosphodiesterase inhibitors in phase I and phase II clinical trials for Alzheimer's disease.
Jos Prickaerts, Pim R A Heckman, Arjan Blokland

Expert Opin Investig Drugs· September 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Phosphodiesterase Inhibition and Regulation of Dopaminergic Frontal and Striatal Functioning: Clinical Implications.
Pim R A Heckman, Marlies A van Duinen, Eva P P Bollen, Akinori Nishi, Lawrence P Wennogle

Int J Neuropsychopharmacol· April 2016

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
Translational issues with the development of cognition enhancing drugs.
Arjan Blokland, Nick van Goethem, Pim Heckman, Rudy Schreiber, Jos Prickaerts

Front Neurol· October 2014

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis