Publications by authors named "Pingda Ren"

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From Lab Formulation Development to CTM Manufacturing of KO-947 Injectable Drug Products: a Case Study and Lessons Learned.
Xiaohu Deng, Pingda Ren, Wanping Mai, Yi Wang, Yuanyang Zhang

AAPS PharmSciTech· June 2021

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Menin inhibitor MI-3454 induces remission in MLL1-rearranged and NPM1-mutated models of leukemia.
Szymon Klossowski, Hongzhi Miao, Katarzyna Kempinska, Tao Wu, Trupta Purohit, Pingda Ren

J Clin Invest· February 2020

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The reactivity-driven biochemical mechanism of covalent KRAS inhibitors.
Rasmus Hansen, Ulf Peters, Anjali Babbar, Yuching Chen, Jun Feng, Pingda Ren

Nat Struct Mol Biol· June 2018

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Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor.
Matthew R Janes, Jingchuan Zhang, Lian-Sheng Li, Rasmus Hansen, Ulf Peters, Matthew V Lorenzi, Pingda Ren

Cell· January 2018

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Selective Inhibition of Oncogenic KRAS Output with Small Molecules Targeting the Inactive State.
Matthew P Patricelli, Matthew R Janes, Lian-Sheng Li, Rasmus Hansen, Ulf Peters, Pingda Ren

Cancer Discov· March 2016

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PI3K-δ and PI3K-γ inhibition by IPI-145 abrogates immune responses and suppresses activity in autoimmune and inflammatory disease models.
David G Winkler, Kerrie L Faia, Jonathan P DiNitto, Janid A Ali, Kerry F White, Pingda Ren

Chem Biol· November 2013

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Selective inhibition of phosphoinositide 3-kinase p110α preserves lymphocyte function.
Lomon So, Sung Su Yea, Jean S Oak, Mengrou Lu, Arun Manmadhan, Pingda Ren

J Biol Chem· February 2013

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PI3 kinase δ is a key regulator of synoviocyte function in rheumatoid arthritis.
Beatrix Bartok, David L Boyle, Yi Liu, Pingda Ren, Scott T Ball

Am J Pathol· May 2012

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The translational landscape of mTOR signalling steers cancer initiation and metastasis.
Andrew C Hsieh, Yi Liu, Merritt P Edlind, Nicholas T Ingolia, Matthew R Janes, Pingda Ren

Nature· February 2012

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Defining the role of TORC1/2 in multiple myeloma.
Patricia Maiso, Yi Liu, Brittany Morgan, Abdel Kareem Azab, Pingda Ren, Irene M Ghobrial

Blood· December 2011

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A type-II kinase inhibitor capable of inhibiting the T315I "gatekeeper" mutant of Bcr-Abl.
Hwan Geun Choi, Pingda Ren, Francisco Adrian, Fangxian Sun, Hyun Soo Lee

J Med Chem· August 2010

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Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor.
Matthew R Janes, Jose J Limon, Lomon So, Jing Chen, Raymond J Lim, Pingda Ren

Nat Med· February 2010

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Discovery of pyrimidine benzimidazoles as Src-family selective Lck inhibitors. Part II.
Guobao Zhang, Pingda Ren, Nathanael S Gray, Taebo Sim, Xia Wang

Bioorg Med Chem Lett· December 2009

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Discovery of pyrimidine benzimidazoles as Lck inhibitors: part I.
Guobao Zhang, Pingda Ren, Nathanael S Gray, Taebo Sim, Yi Liu

Bioorg Med Chem Lett· October 2008

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A general strategy for creating "inactive-conformation" abl inhibitors.
Barun Okram, Advait Nagle, Francisco J Adrián, Christian Lee, Pingda Ren

Chem Biol· July 2006

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A genome-wide overexpression screen in yeast for small-molecule target identification.
Hendrik Luesch, Tom Y H Wu, Pingda Ren, Nathanael S Gray, Peter G Schultz

Chem Biol· January 2005

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Catalytic asymmetric benzylic C-H activation by means of carbenoid-induced C-H insertions.
Huw M L Davies, Qihui Jin, Pingda Ren, Andrey Yu Kovalevsky

J Org Chem· June 2002

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Synthesis of iodinated 3beta-aryltropanes with selective binding to either the dopamine or serotonin transporters.
Huw M L Davies, Pingda Ren, Norman X Kong, Tammy Sexton, Steven R Childers

Bioorg Med Chem Lett· March 2002

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