Publications by authors named "Prabhakar B T"

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Allium sativum lectin as an immunotherapeutic agent: Eliciting IFN-γ production via "M1" macrophage polarization to trigger JAK1/STAT1 and DDR mediated lung cancer cell death.
B K Kiran, B M Siddesh, Ankith Sherapura, Prabhu Thirusangu, B R Vijay Avin

Int J Biol Macromol· November 2025

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A quinoline derivative exerts antineoplastic efficacy against solid tumour by inducing apoptosis and anti-angiogenesis both in vitro and in vivo.
Pradeepa Kumar C, Banumathi, N D Satyanarayan, Sakshith Raghavendra Prasad, Rajeshwara N Achur

Naunyn Schmiedebergs Arch Pharmacol· July 2025

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Immunomodulatory lectin from Cordia myxa targets PI3K/AKT signalling mediated apoptosis to regress both in-vitro and in-vivo tumour.
B M Siddesh, B K Kiran, Ankith Sherapura, Banumathi, Riaz Mahmood

Int J Biol Macromol· March 2025

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Withaferin-A induced vimentin S56 phosphorylation dissociates NEDD9 signaling loop to regress progressive metastatic melanoma into lung adenocarcinoma.
Ankith Sherapura, B K Kiran, G S Pavan Kumar, B M Siddesh, Prabhu Thirusangu

Chem Biol Interact· January 2025

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Steroidal alkaloid solanidine impedes hypoxia-driven ATM phosphorylation to switch on anti-angiogenesis in lung adenocarcinoma.
Ankith Sherapura, B M Siddesh, Vikas H Malojirao, Prabhu Thirusangu, B R Vijay Avin

Phytomedicine· October 2023

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Matrix-Metalloproteinase Inhibitory Study of Novel Tetrahydroisoquinoline-4-carboxylates: Design, Synthesis, and Molecular Docking Studies.
Nayak Devappa Satyanarayan, Manjunatha Kammathalli Siddappa, Abdul Rahman, Nippu Belur Ningegowda, Ankith Sherapura

Chem Biodivers· May 2023

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Novel Benzimidazole Derived Imine Ligand and Its Co(III) and Cu(II) Complexes as Anticancer Agents: Chemical Synthesis, DFT Studies, In Vitro and In Vivo Biological Investigations.
Prakasha G, H D Revanasiddappa, Jayalakshmi B, Prabhakar B T, Chandan Shivamallu

Pharmaceuticals (Basel)· January 2023

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A systems biology investigation of curcumin potency against TGF-β-induced EMT signaling in lung cancer.
Shivananda Kandagalla, B S Sharath, Ankith Sherapura, Maria Grishina, Vladimir Potemkin

3 Biotech· November 2022

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Antiproliferative pharmacophore azo-hydrazone analogue BT-1F exerts death signalling pathway targeting STAT3 in solid tumour.
Banumathi, Ankith Sherapura, Vikas H Malojirao, Zabiulla, B S Sharath

Pharmacol Rep· April 2022

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Anti-neoplastic pharmacophore benzophenone-1 coumarin (BP-1C) targets JAK2 to induce apoptosis in lung cancer.
Ankith Sherapura, Vikas H Malojirao, Prabhu Thirusangu, B S Sharath, Shivananda Kandagalla

Apoptosis· February 2022

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Immunoadjuvant and Humoral Immune Responses of Garlic ( L.) Lectins upon Systemic and Mucosal Administration in BALB/c Mice.
Shruthishree D Padiyappa, Hemavathi Avalappa, Madhusudana Somegowda, Shankarappa Sridhara, Yeldur P Venkatesh

Molecules· February 2022

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Targeting HIF-1α by newly synthesized Indolephenoxyacetamide (IPA) analogs to induce anti-angiogenesis-mediated solid tumor suppression.
Fares Hezam Al-Ostoot, Ankith Sherapura, Vigneshwaran V, Giridhara Basappa, Vivek H K

Pharmacol Rep· October 2021

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Modulation of DNA damage response by targeting ATM kinase using newly synthesized di-phenoxy acetamide (DPA) analogs to induce anti-neoplasia.
Fares Hezam Al-Ostoot, Ankith Sherapura, Vikas H Malojirao, Prabhu Thirusangu, Tahani I Al-Muhimeed

Pharmacol Rep· October 2021

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Novel 1,3,4-oxadiazole Targets STAT3 Signaling to Induce Antitumor Effect in Lung Cancer.
Vikas H Malojirao, Swamy S Girimanchanaika, Muthu K Shanmugam, Ankith Sherapura, Dukanya

Biomedicines· September 2020

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A systems biology approach to identify the key targets of curcumin and capsaicin that downregulate pro-inflammatory pathways in human monocytes.
Sharath Belenahalli Shekarappa, Shivananda Kandagalla, Vikas H Malojirao, Pavan Kumar G S, Prabhakar B T

Comput Biol Chem· December 2019

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Synthesis of coumarin analogs appended with quinoline and thiazole moiety and their apoptogenic role against murine ascitic carcinoma.
T Prashanth, B R Vijay Avin, Prabhu Thirusangu, V Lakshmi Ranganatha, B T Prabhakar

Biomed Pharmacother· April 2019

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Synthesis and amelioration of inflammatory paw edema by novel benzophenone appended oxadiazole derivatives by exhibiting cyclooxygenase-2 antagonist activity.
Naveen Puttaswamy, Vikas H Malojiao, Yasser Hussein Eissa Mohammed, Ankith Sherapura, B T Prabhakar

Biomed Pharmacother· July 2018

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The Novel 4-Phenyl-2-Phenoxyacetamide Thiazoles modulates the tumor hypoxia leading to the crackdown of neoangiogenesis and evoking the cell death.
Yasser Hussein Eissa Mohammed, Vikas H Malojirao, Prabhu Thirusangu, Mohammed Al-Ghorbani, B T Prabhakar

Eur J Med Chem· January 2018

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The anti-invasive role of novel synthesized pyridazine hydrazide appended phenoxy acetic acid against neoplastic development targeting matrix metallo proteases.
Yasser Hussein Eissa Mohammed, Prabhu Thirusangu, Zabiulla, Vigneshwaran V, Prabhakar B T

Biomed Pharmacother· November 2017

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Design and synthesis of conjugated azo-hydrazone analogues using nano BF·SiO targeting ROS homeostasis in oncogenic and vascular progression.
Zabiulla, V Vigneshwaran, A Begum Bushra, G S Pavankumar, B T Prabhakar

Biomed Pharmacother· November 2017

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Immunomodulatory glc/man-directed Dolichos lablab lectin (DLL) evokes anti-tumour response in vivo by counteracting angiogenic gene expressions.
V Vigneshwaran, P Thirusangu, B R Vijay Avin, V Krishna, S N Pramod

Clin Exp Immunol· July 2017

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Synthesis of novel morpholine conjugated benzophenone analogues and evaluation of antagonistic role against neoplastic development.
Mohammed Al-Ghorbani, Prabhu Thirusangu, H D Gurupadaswamy, V Vigneshwaran, Yasser H E Mohammed

Bioorg Chem· April 2017

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A tumoural angiogenic gateway blocker, Benzophenone-1B represses the HIF-1α nuclear translocation and its target gene activation against neoplastic progression.
Prabhu Thirusangu, V Vigneshwaran, V Lakshmi Ranganatha, B R Vijay Avin, Shaukath Ara Khanum

Biochem Pharmacol· February 2017

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Scutellarein antagonizes the tumorigenesis by modulating cytokine VEGF mediated neoangiogenesis and DFF-40 actuated nucleosomal degradation.
Prabhu Thirusangu, V Vigneshwaran, B R Vijay Avin, H Rakesh, H M Vikas

Biochem Biophys Res Commun· February 2017

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