Publications by authors named "Pras Pathmanathan"

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Preclinical Validation of a Patient-Specific Patch-Planning Workflow for Congenital Cardiovascular Reconstruction.
Shannen B Kizilski, Dominic P Recco, Jocelyn M Davee, Ashley Masterson, Jiang Yao, Pras Pathmanathan

Ann Biomed Eng· December 2025

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Computational Modeling and Simulation for Medical Devices: A Summary of the 2024 FDA/MDIC Symposium.
Brent A Craven, Christopher A Basciano, Payman Afshari, Kenneth I Aycock, Jeff J Ballyns, Pras Pathmanathan

Prog Biomed Eng (Bristol)· November 2025

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Assessing the reliability of medical resource demand models in the context of COVID-19.
Kimberly Dautel, Ephraim Agyingi, Pras Pathmanathan

BMC Med Inform Decis Mak· October 2024

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Credibility assessment of in silico clinical trials for medical devices.
Pras Pathmanathan, Kenneth Aycock, Andreu Badal, Ramin Bighamian, Jeff Bodner

PLoS Comput Biol· August 2024

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Toward trustworthy medical device clinical trials: a hierarchical framework for establishing credibility and strategies for overcoming key challenges.
Kenneth I Aycock, Tom Battisti, Ashley Peterson, Jiang Yao, Steven Kreuzer, Pras Pathmanathan

Front Med (Lausanne)· August 2024

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A computational modeling framework for pre-clinical evaluation of cardiac mapping systems.
Suran Galappaththige, Pras Pathmanathan, Richard A Gray

Front Physiol· July 2023

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Validation framework for epidemiological models with application to COVID-19 models.
Kimberly A Dautel, Ephraim Agyingi, Pras Pathmanathan

PLoS Comput Biol· March 2023

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Editorial on the FDA Report on "Successes and Opportunities in Modeling & Simulation for FDA".
Kausar B Riaz Ahmed, Pras Pathmanathan, Shruti V Kabadi, Tomas Drgon, Tina M Morrison

Ann Biomed Eng· January 2023

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Development and validation of a mathematical model of heart rate response to fluid perturbation.
Varun Kanal, Pras Pathmanathan, Jin-Oh Hahn, George Kramer, Christopher Scully

Sci Rep· December 2022

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Credibility assessment of patient-specific computational modeling using patient-specific cardiac modeling as an exemplar.
Suran Galappaththige, Richard A Gray, Caroline Mendonca Costa, Steven Niederer, Pras Pathmanathan

PLoS Comput Biol· October 2022

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Design and execution of a verification, validation, and uncertainty quantification plan for a numerical model of left ventricular flow after LVAD implantation.
Alfonso Santiago, Constantine Butakoff, Beatriz Eguzkitza, Richard A Gray, Karen May-Newman, Pras Pathmanathan

PLoS Comput Biol· June 2022

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Evaluation framework for systems models.
Sietse Braakman, Pras Pathmanathan, Helen Moore

CPT Pharmacometrics Syst Pharmacol· March 2022

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A Quantitative Systems Pharmacology Perspective on the Importance of Parameter Identifiability.
Anna Sher, Steven A Niederer, Gary R Mirams, Anna Kirpichnikova, Richard Allen, Pras Pathmanathan

Bull Math Biol· February 2022

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Credibility Assessment of a Subject-Specific Mathematical Model of Blood Volume Kinetics for Prediction of Physiological Response to Hemorrhagic Shock and Fluid Resuscitation.
Bahram Parvinian, Ramin Bighamian, Christopher George Scully, Jin-Oh Hahn, Pras Pathmanathan

Front Physiol· September 2021

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The 'Digital Twin' to enable the vision of precision cardiology.
Jorge Corral-Acero, Francesca Margara, Maciej Marciniak, Cristobal Rodero, Filip Loncaric, Pras Pathmanathan

Eur Heart J· December 2020

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Data-Driven Uncertainty Quantification for Cardiac Electrophysiological Models: Impact of Physiological Variability on Action Potential and Spiral Wave Dynamics.
Pras Pathmanathan, Suran K Galappaththige, Jonathan M Cordeiro, Abouzar Kaboudian, Flavio H Fenton

Front Physiol· November 2020

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Considering discrepancy when calibrating a mechanistic electrophysiology model.
Chon Lok Lei, Sanmitra Ghosh, Dominic G Whittaker, Yasser Aboelkassem, Kylie A Beattie, Pras Pathmanathan

Philos Trans A Math Phys Eng Sci· June 2020

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Chaste: Cancer, Heart and Soft Tissue Environment.
Fergus R Cooper, Ruth E Baker, Miguel O Bernabeu, Rafel Bordas, Louise Bowler, Pras Pathmanathan

J Open Source Softw· March 2020

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Comprehensive Uncertainty Quantification and Sensitivity Analysis for Cardiac Action Potential Models.
Pras Pathmanathan, Jonathan M Cordeiro, Richard A Gray

Front Physiol· June 2019

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Effect of Heart Structure on Ventricular Fibrillation in the Rabbit: A Simulation Study.
Suran K Galappaththige, Pras Pathmanathan, Martin J Bishop, Richard A Gray

Front Physiol· May 2019

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Credibility Evidence for Computational Patient Models Used in the Development of Physiological Closed-Loop Controlled Devices for Critical Care Medicine.
Bahram Parvinian, Pras Pathmanathan, Chathuri Daluwatte, Farid Yaghouby, Richard A Gray

Front Physiol· March 2019

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Applying a Computational Model Credibility Framework to Physiological Closed-loop Controlled Medical Device Testing.
Christopher G Scully, Pras Pathmanathan, Chathuri Daluwatte, Farid Yaghouby, Richard A Gray

IEEE Life Sci Conf· October 2018

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Advancing Regulatory Science With Computational Modeling for Medical Devices at the FDA's Office of Science and Engineering Laboratories.
Tina M Morrison, Pras Pathmanathan, Mariam Adwan, Edward Margerrison

Front Med (Lausanne)· September 2018

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Patient-Specific Cardiovascular Computational Modeling: Diversity of Personalization and Challenges.
Richard A Gray, Pras Pathmanathan

J Cardiovasc Transl Res· April 2018

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Validation and Trustworthiness of Multiscale Models of Cardiac Electrophysiology.
Pras Pathmanathan, Richard A Gray

Front Physiol· February 2018

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