Publications by authors named "Prashant B Nigade"

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Dual PI3Kδγ inhibition demonstrates potent anticancer effects in diffuse large B-cell lymphoma models: Discovery and preclinical characterization of LL-00084282.
Mahip K Verma, Charudatt Samant, Ramesh Kale, Sukanya Patra, Nilesh Mahajan, Prashant B Nigade

Biochem Biophys Res Commun· December 2022

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LL-00066471, a novel positive allosteric modulator of α7 nicotinic acetylcholine receptor ameliorates cognitive and sensorimotor gating deficits in animal models: Discovery and preclinical characterization.
Mahip K Verma, Rajan N Goel, Anand M Bokare, Manoj P Dandekar, Sarita Koul, Prashant B Nigade

Eur J Pharmacol· January 2021

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Discovery of isoquinolinone and naphthyridinone-based inhibitors of poly(ADP-ribose) polymerase-1 (PARP1) as anticancer agents: Structure activity relationship and preclinical characterization.
Navnath P Karche, Mandar Bhonde, Neelima Sinha, Gourhari Jana, Gagan Kukreja, Prashant B Nigade

Bioorg Med Chem· December 2020

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Discovery of Potent, Selective, and State-Dependent Na1.7 Inhibitors with Robust Oral Efficacy in Pain Models: Structure-Activity Relationship and Optimization of Chroman and Indane Aryl Sulfonamides.
Vidya Ramdas, Rashmi Talwar, Vijay Kanoje, Rajesh M Loriya, Moloy Banerjee, Prashant B Nigade

J Med Chem· June 2020

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Discovery of Novel, Potent, Brain-Permeable, and Orally Efficacious Positive Allosteric Modulator of α7 Nicotinic Acetylcholine Receptor [4-(5-(4-Chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)benzenesulfonamide]: Structure-Activity Relationship and Preclinical Characterization.
Neelima Sinha, Navnath P Karche, Mahip Kalyan Verma, Sameer S Walunj, Prashant B Nigade

J Med Chem· February 2020

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Prediction of volume of distribution in preclinical species and humans: application of simplified physiologically based algorithms.
Prashant B Nigade, Jayasagar Gundu, K Sreedhara Pai, Kumar V S Nemmani, Rashmi Talwar

Xenobiotica· May 2019

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Prediction of Tumor-to-Plasma Ratios of Basic Compounds in Subcutaneous Xenograft Mouse Models.
Prashant B Nigade, Jayasagar Gundu, K Sreedhara Pai, Kumar V S Nemmani

Eur J Drug Metab Pharmacokinet· June 2018

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Prediction of Tissue-to-Plasma Ratios of Basic Compounds in Mice.
Prashant B Nigade, Jayasagar Gundu, K Sreedhara Pai, Kumar V S Nemmani

Eur J Drug Metab Pharmacokinet· October 2017

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Cardioprotective effect of Azadirachta indica A. Juss. on isoprenaline induced myocardial infarction in rats.
Prashee A Peer, Purvi C Trivedi, Prashant B Nigade, Mahesh M Ghaisas, Avinash D Deshpande

Int J Cardiol· May 2008

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