Publications by authors named "Pravin Kotian"

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Absolute Configuration of Key Intermediates and the Gram Scale Synthesis of Berotralstat and Berotralstat.
Pravin L Kotian, Satish Vadlakonda, Venkat Chintareddy, Minwan Wu, Weihe Zhang

J Org Chem· October 2025

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Design, synthesis, and structure-activity relationships of selective biphenyl antithrombotic tissue factor/factor VIIa inhibitors.
Pravin L Kotian, Yahya El-Kattan, Shri Niwas, Minwan Wu, Tsu-Hsing Lin

Eur J Med Chem· September 2025

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Regioselective alkylation of a versatile indazole: Electrophile scope and mechanistic insights from density functional theory calculations.
Pengcheng Lu, Luis Juarez, Paul A Wiget, Weihe Zhang, Krishnan Raman, Pravin L Kotian

Beilstein J Org Chem· August 2024

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Synthesis and biological evaluation of Ribo 7-N/O/S pyrimidine 9-deaza C-nucleoside analogs as new antiviral agents for inhibiting HCV RNA-dependent RNA polymerases.
Minwan Wu, Satish Vadlakonda, Yahya El-Kattan, Ajit Ghosh, Tsu-Hsing Lin, Pravin L Kotian

Eur J Med Chem· January 2024

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Synthesis of novel azasugar-containing 2'β-C-Me 9-deaza nucleosides as potential anti-hepatitis C virus agents.
Pravin L Kotian, Minwan Wu, Ajit Ghosh, Kevin J Polach, Yahya El-Kattan

Nucleosides Nucleotides Nucleic Acids· March 2023

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Discovery and optimization of orally bioavailable and potent plasma Kallikrein inhibitors bearing a quaternary carbon.
Weihe Zhang, Satish Vadlakonda, Minwan Wu, Venkat Chintareddy, L N Vogeti, Pravin Kotian

Bioorg Med Chem· November 2022

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Scaffold hopping via ring opening enables identification of acyclic compounds as new complement Factor D inhibitors.
Weihe Zhang, Minwan Wu, Satish Vadlakonda, Luis Juarez, Xiaogang Cheng, Pravin Kotian

Bioorg Med Chem· November 2022

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Berotralstat (BCX7353): Structure-Guided Design of a Potent, Selective, and Oral Plasma Kallikrein Inhibitor to Prevent Attacks of Hereditary Angioedema (HAE).
Pravin L Kotian, Minwan Wu, Satish Vadlakonda, Venkat Chintareddy, Pengcheng Lu

J Med Chem· September 2021

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BCX4430 - A broad-spectrum antiviral adenosine nucleoside analog under development for the treatment of Ebola virus disease.
Raymond Taylor, Pravin Kotian, Travis Warren, Rekha Panchal, Sina Bavari

J Infect Public Health· January 2017

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BCX4430, a novel nucleoside analog, effectively treats yellow fever in a Hamster model.
Justin G Julander, Shanta Bantia, Brian R Taubenheim, Dena M Minning, Pravin Kotian

Antimicrob Agents Chemother· November 2014

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Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430.
Travis K Warren, Jay Wells, Rekha G Panchal, Kelly S Stuthman, Nicole L Garza, Pravin Kotian

Nature· April 2014

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Potent orally bioavailable purine nucleoside phosphorylase inhibitor BCX-4208 induces apoptosis in B- and T-lymphocytes--a novel treatment approach for autoimmune diseases, organ transplantation and hematologic malignancies.
Shanta Bantia, Cynthia Parker, Ramanda Upshaw, Amanda Cunningham, Pravin Kotian

Int Immunopharmacol· July 2010

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Design, parallel synthesis, and crystal structures of biphenyl antithrombotics as selective inhibitors of tissue factor FVIIa complex. Part 1: Exploration of S2 pocket pharmacophores.
Pravin L Kotian, Raman Krishnan, Scott Rowland, Yahya El-Kattan, Surendra K Saini

Bioorg Med Chem· June 2009

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Probing the S2 site of factor VIIa to generate potent and selective inhibitors: the structure of BCX-3607 in complex with tissue factor-factor VIIa.
Raman Krishnan, Pravin L Kotian, Pooran Chand, Shanta Bantia, Scott Rowland

Acta Crystallogr D Biol Crystallogr· June 2007

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Benzoic acid and pyridine derivatives as inhibitors of Trypanosoma cruzi trans-sialidase.
João Neres, Pascal Bonnet, Philip N Edwards, Pravin L Kotian, Alejandro Buschiazzo

Bioorg Med Chem· March 2007

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The antithrombotic and anti-inflammatory effects of BCX-3607, a small molecule tissue factor/factor VIIa inhibitor.
C Shane Arnold, Cynthia Parker, Ramanda Upshaw, Hans Prydz, Pooran Chand, Pravin Kotian

Thromb Res· June 2006

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An efficient synthesis of acyclic N7- and N9-adenine nucleosides via alkylation with secondary carbon electrophiles to introduce versatile functional groups at the C-1 position of acyclic moiety.
Pravin L Kotian, V Satish Kumar, Tsu-Hsing Lin, Yahya El-Kattan, Ajit Ghosh

Nucleosides Nucleotides Nucleic Acids· June 2006

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Synthesis of 9-[1-(substituted)-3-(phosphonomethoxy)propyl]adenine derivatives as possible antiviral agents.
Minwan Wu, Yahya El-Kattan, Tsu-Hsing Lin, Ajit Ghosh, Satish Vadlakonda, Pravin L Kotian

Nucleosides Nucleotides Nucleic Acids· March 2006

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Synthesis of 9-[1-(substituted)-2-(phosphonomethoxy)ethyl]adenine derivatives as possible antiviral agents.
Minwan Wu, Yahya El-Kattan, Tsu-Hsing Lin, Ajit Ghosh, V Satish Kumar, Pravin L Kotian

Nucleosides Nucleotides Nucleic Acids· March 2006

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Synthesis of 9-[1-(1 -hydroxyethyl)-3-(phosphonomethoxy)propyl]adenine and prodrug as possible antiviral agents.
Ajit Ghosh, Yahya El-Kattan, Minwan Wu, Tsu-Hsing Lin, Satish Vadlakonda, Pravin L Kotian

Nucleosides Nucleotides Nucleic Acids· March 2006

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Synthesis of N6-substituted 9-[3-(phosphonomethoxy)propyl]adenine derivatives as possible antiviral agents.
Yahya El-Kattan, Tsu-Hsing Lin, Minwan Wu, V Satish Kumar, Pravin L Kotian

Nucleosides Nucleotides Nucleic Acids· March 2006

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Comparison of the anti-influenza virus activity of cyclopentane derivatives with oseltamivir and zanamivir in vivo.
Pooran Chand, Shanta Bantia, Pravin L Kotian, Yahya El-Kattan, Tsu-Hsing Lin

Bioorg Med Chem· June 2005

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Synthesis and inhibitory activity of benzoic acid and pyridine derivatives on influenza neuraminidase.
Pooran Chand, Pravin L Kotian, Philip E Morris, Shanta Bantia, David A Walsh

Bioorg Med Chem· April 2005

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Syntheses and neuraminidase inhibitory activity of multisubstituted cyclopentane amide derivatives.
Pooran Chand, Y Sudhakar Babu, Shanta Bantia, Scott Rowland, Ali Dehghani, Pravin L Kotian

J Med Chem· April 2004

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