Publications by authors named "Prema Iyer"

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An SH3-binding allosteric modulator stabilizes the global conformation of the AML-associated Src-family kinase, Hck.
Ari M Selzer, Gabriella Gerlach, Giancarlo Gonzalez-Areizaga, Thomas E Wales, Stephanie Y Cui, Prema Iyer

J Biol Chem· January 2025

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Current Landscape of Coccidioidomycosis.
Ryan Boro, Prema C Iyer, Maciej A Walczak

J Fungi (Basel)· April 2022

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GAC inhibitors with a 4-hydroxypiperidine spacer: Requirements for potency.
Lee McDermott, David Koes, Shabber Mohammed, Prema Iyer, Melissa Boby

Bioorg Med Chem Lett· October 2019

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Characterization of the interactions of potent allosteric inhibitors with glutaminase C, a key enzyme in cancer cell glutamine metabolism.
Qingqiu Huang, Clint Stalnecker, Chengliang Zhang, Lee A McDermott, Prema Iyer

J Biol Chem· March 2018

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Connecting Neuronal Cell Protective Pathways and Drug Combinations in a Huntington's Disease Model through the Application of Quantitative Systems Pharmacology.
Fen Pei, Hongchun Li, Mark J Henderson, Steven A Titus, Ajit Jadhav, Prema Iyer

Sci Rep· December 2017

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Design and evaluation of novel glutaminase inhibitors.
Lee A McDermott, Prema Iyer, Larry Vernetti, Shawn Rimer, Jingran Sun

Bioorg Med Chem· April 2016

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Design and activity of AP endonuclease-1 inhibitors.
Zhiwei Feng, Stanton Kochanek, David Close, LiRong Wang, Ajay Srinivasan, Prema Iyer

J Chem Biol· July 2015

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Synthesis and structure-activity analysis of diphenylpyrazolodiazene inhibitors of the HIV-1 Nef virulence factor.
Prema C Iyer, Jielu Zhao, Lori A Emert-Sedlak, Kerry K Moore, Thomas E Smithgall

Bioorg Med Chem Lett· April 2014

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Synthesis and characterization of DNA minor groove binding alkylating agents.
Prema Iyer, Ajay Srinivasan, Sreelekha K Singh, Gerard P Mascara, Sevara Zayitova

Chem Res Toxicol· January 2013

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XRCC1 deficiency influences the cytotoxicity and the genomic instability induced by Me-lex, a specific inducer of N3-methyladenine.
Debora Russo, Gilberto Fronza, Laura Ottaggio, Paola Monti, Chiara Perfumo, Prema Iyer

DNA Repair (Amst)· July 2010

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Mutagenicity of N3-methyladenine: a multi-translesion polymerase affair.
Paola Monti, Ilaria Traverso, Laura Casolari, Paola Menichini, Alberto Inga, Prema Iyer

Mutat Res· January 2010

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High frequency of genomic deletions induced by Me-lex, a sequence selective N3-adenine methylating agent, at the Hprt locus in Chinese hamster ovary cells.
Debora Russo, Gilberto Fronza, Laura Ottaggio, Paola Monti, Alberto Inga, Prema Iyer

Mutat Res· December 2009

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3'-H-phosphonate synthesis of chiral benzo[a]pyrene diol epoxide adducts at N(2) of deoxyguanosine in oligonucleotides.
Prema C Iyer, Haruhiko Yagi, Jane M Sayer, Donald M Jerina

Chem Res Toxicol· February 2007

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