Publications by authors named "Pui-Yan Ho"

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Structural and mechanistic insights into herpesvirus helicase-primase and its therapeutic inhibitors.
Qing Yao, Alexandre Mercier, Arabinda Nayak, Lindsey May, Pui Yan Ho, Thomas Aeschbacher, Aesop Cho

Nat Microbiol· December 2025

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SARS-CoV-2 Resistance Analyses From the Phase 3 OAKTREE Study of Obeldesivir in Low-Risk Nonhospitalized Participants With COVID-19.
Lauren Rodriguez, Yu Hu, Jiani Li, Dong Han, Nadine Peinovich, Pui Yan Ho

Antiviral Res· December 2025

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Remdesivir and Obeldesivir Retain Potent Antiviral Activity Against SARS-CoV-2 Omicron Variants.
Lauren Rodriguez, J Lizbeth Reyes Zamora, Dong Han, Jasmine Moshiri, Nadine Peinovich, Pui Yan Ho, Thomas Aeschbacher

Viruses· January 2025

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Targeted hematopoietic stem cell depletion through SCF-blockade.
Yan Yi Chan, Pui Yan Ho, Carla Dib, Leah Swartzrock, Maire Rayburn, Katie Ho, Agnieszka Czechowicz

Stem Cell Res Ther· October 2024

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Physioxia improves the selectivity of hematopoietic stem cell expansion cultures.
Kyomi J Igarashi, Iwo Kucinski, Yan Yi Chan, Tze-Kai Tan, Hwei Minn Khoo, Pui Yan Ho, Agnieszka Czechowicz, Berthold Gottgens

Blood Adv· July 2023

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Non-genotoxic Restoration of the Hematolymphoid System in Fanconi Anemia.
Yan Yi Chan, Pui Yan Ho, Leah Swartzrock, Maire Rayburn, Rofida Nofal, Supawat Thongthip, Agnieszka Czechowicz

Transplant Cell Ther· March 2023

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Nanoradiosensitizer with good tissue penetration and enhances oral cancer radiotherapeutic effect.
Di Jing, Nian Jiang, Fengyi Wang, Chunping Mao, Shujun Han, Pui Yan Ho

Biomaterials· October 2022

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Peptide nucleic acid-dependent artifact can lead to false-positive triplex gene editing signals.
Pui Yan Ho, Zhen Zhang, Mark E Hayes, Andrew Curd, Carla Dib, Agnieszka Czechowicz

Proc Natl Acad Sci U S A· November 2021

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fermentation production of humanized noncoding RNAs carrying payload miRNAs for targeted anticancer therapy.
Peng-Cheng Li, Mei-Juan Tu, Pui Yan Ho, Neelu Batra, Michelle M L Tran

Theranostics· August 2021

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Single bioengineered ncRNA molecule for dual-targeting toward the control of non-small cell lung cancer patient-derived xenograft tumor growth.
Hannah Petrek, Pui Yan Ho, Neelu Batra, Mei-Juan Tu, Qianyu Zhang

Biochem Pharmacol· July 2021

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A Novel Bioengineered miR-127 Prodrug Suppresses the Growth and Metastatic Potential of Triple-Negative Breast Cancer Cells.
Maxine Umeh-Garcia, Catalina Simion, Pui-Yan Ho, Neelu Batra, Anastasia L Berg

Cancer Res· February 2020

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Head and neck squamous cancer progression is marked by CLIC4 attenuation in tumor epithelium and reciprocal stromal upregulation of miR-142-3p, a novel post-transcriptional regulator of .
Brandi L Carofino, Kayla M Dinshaw, Pui Yan Ho, Christophe Cataisson, Aleksandra M Michalowski

Oncotarget· December 2019

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Bioengineering of a single long noncoding RNA molecule that carries multiple small RNAs.
Hannah Petrek, Neelu Batra, Pui Yan Ho, Mei-Juan Tu, Ai-Ming Yu

Appl Microbiol Biotechnol· August 2019

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Creatine based polymer for codelivery of bioengineered MicroRNA and chemodrugs against breast cancer lung metastasis.
Jieni Xu, Jingjing Sun, Pui Yan Ho, Zhangyi Luo, Weina Ma, Sanjay B Rathod

Biomaterials· July 2019

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Bioengineered miR-27b-3p and miR-328-3p modulate drug metabolism and disposition the regulation of target ADME gene expression.
Xin Li, Ye Tian, Mei-Juan Tu, Pui Yan Ho, Neelu Batra

Acta Pharm Sin B· May 2019

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Bioengineered Let-7c Inhibits Orthotopic Hepatocellular Carcinoma and Improves Overall Survival with Minimal Immunogenicity.
Joseph L Jilek, Qian-Yu Zhang, Mei-Juan Tu, Pui Yan Ho, Zhijian Duan

Mol Ther Nucleic Acids· March 2019

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Bioengineered miRNA-1291 prodrug therapy in pancreatic cancer cells and patient-derived xenograft mouse models.
Mei-Juan Tu, Pui Yan Ho, Qian-Yu Zhang, Chao Jian, Jing-Xin Qiu

Cancer Lett· February 2019

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Lipidation of polyethylenimine-based polyplex increases serum stability of bioengineered RNAi agents and offers more consistent tumoral gene knockdown in vivo.
Qian-Yu Zhang, Pui Yan Ho, Mei-Juan Tu, Joseph L Jilek, Qiu-Xia Chen

Int J Pharm· August 2018

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Bioengineered Noncoding RNAs Selectively Change Cellular miRNome Profiles for Cancer Therapy.
Pui Yan Ho, Zhijian Duan, Neelu Batra, Joseph L Jilek, Mei-Juan Tu, Hong-Wu Chen

J Pharmacol Exp Ther· June 2018

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Bioengineered NRF2-siRNA Is Effective to Interfere with NRF2 Pathways and Improve Chemosensitivity of Human Cancer Cells.
Peng-Cheng Li, Mei-Juan Tu, Pui Yan Ho, Joseph L Jilek, Zhijian Duan

Drug Metab Dispos· January 2018

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Co-targeting of DNA, RNA, and protein molecules provides optimal outcomes for treating osteosarcoma and pulmonary metastasis in spontaneous and experimental metastasis mouse models.
Chao Jian, Mei-Juan Tu, Pui Yan Ho, Zhijian Duan, Qianyu Zhang

Oncotarget· May 2017

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Bioengineering of noncoding RNAs for research agents and therapeutics.
Pui Yan Ho, Ai-Ming Yu

Wiley Interdiscip Rev RNA· December 2016

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MicroRNA Pharmacoepigenetics: Posttranscriptional Regulation Mechanisms behind Variable Drug Disposition and Strategy to Develop More Effective Therapy.
Ai-Ming Yu, Ye Tian, Mei-Juan Tu, Pui Yan Ho, Joseph L Jilek

Drug Metab Dispos· March 2016

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Bioengineering Novel Chimeric microRNA-34a for Prodrug Cancer Therapy: High-Yield Expression and Purification, and Structural and Functional Characterization.
Wei-Peng Wang, Pui Yan Ho, Qiu-Xia Chen, Balasubrahmanyam Addepalli, Patrick A Limbach, Hong-Jian Zhang, Tianhong Li

J Pharmacol Exp Ther· August 2015

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