Publications by authors named "Qiyan Lin"

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LC-HRMS profiling of Dendrobium huoshanense aqueous extract and its therapeutic effects on nonalcoholic fatty liver disease in mice through the TLR2-NF-κB and AMPK-SREBP1-SIRT1 signaling pathways.
Qiyan Lin, Ke Huang, Xiyu Ge, Menghua Ma, Wei Wang

J Chromatogr B Analyt Technol Biomed Life Sci· April 2025

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Wuzi Yanzong Decoction Ameliorates Oligoasthenozoospermia by Up-Regulating Methyltransferase and Increasing Spata, Bcl, and Pik3 Series Genes Methylation Level.
Qiyan Lin, Xiyu Ge, Xia Li, Fangli Gu, Leilei Gao

Chem Biodivers· March 2025

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Betaine alleviates spermatogenic cells apoptosis of oligoasthenozoospermia rat model by up-regulating methyltransferases and affecting DNA methylation.
Qiyan Lin, Xiyu Ge, Leilei Gao, Yanjun Chen, Ting Su

Phytomedicine· July 2024

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Dopey2 and Pcdh7 orchestrate the development of embryonic neural stem cells/ progenitors in zebrafish.
Yue Xiao, Min Hu, Qiyan Lin, Ting Zhang, Siying Li, Linjuan Shu

iScience· March 2023

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Solitary fibrous tumor of the central nervous system invading and penetrating the skull: A case report.
Qiyan Lin, Jiabin Zhu, Xiaofeng Zhang

Oncol Lett· February 2023

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Discovery of 1'-(1-phenylcyclopropane-carbonyl)-3H-spiro[isobenzofuran-1,3'-pyrrolidin]-3-one as a novel steroid mimetic scaffold for the potent and tissue-specific inhibition of 11β-HSD1 using a scaffold-hopping approach.
Colin Zhang, Meizhong Xu, Chunhong He, Jincong Zhuo, David M Burns, Qiyan Lin, Linkai Weng

Bioorg Med Chem Lett· August 2022

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Metabolic profiling and pharmacokinetic studies of sinapine thiocyanate by UHPLC-Q/TOF-MS and UHPLC-MS/MS.
Huida Guan, Qiyan Lin, Chao Ma, Zhengcai Ju, Changhong Wang

J Pharm Biomed Anal· January 2022

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Pharmacokinetic studies of ginsenosides Rk1 and Rg5 in rats by UFLC-MS/MS.
Chao Ma, Qiyan Lin, Yafu Xue, Zhengcai Ju, Gang Deng

Biomed Chromatogr· August 2021

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Biotransformation patterns of dictamnine in vitro/in vivo and its relative molecular mechanism of dictamnine-induced acute liver injury in mice.
Qiyan Lin, Huida Guan, Chao Ma, Liangni Chen, Lanlan Cao

Environ Toxicol Pharmacol· July 2021

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Dynamic changes in chemical compositions and anti-acetylcholinesterase activity associated with steaming process of stem-leaf saponins of Panax notoginseng.
Chao Ma, Huida Guan, Qiyan Lin, Chang Liu, Zhengcai Ju

Biomed Chromatogr· June 2021

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Metabolites identification and reversible interconversion of chelerythrine and dihydrochelerythrine in vitro/in vivo in rats using ultra-performance liquid chromatography combined with electrospray ionization quadrupole time-of-flight tandem mass spectrometry.
Qiyan Lin, Chao Ma, Huida Guan, Liangni Chen, Qi Xie

J Pharm Biomed Anal· September 2020

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Rapid identification and pharmacokinetic studies of multiple active alkaloids in rat plasma through UPLC-Q-TOF-MS and UPLC-MS/MS after the oral administration of Zanthoxylum nitidum extract.
Qiyan Lin, Hongli Pu, Huida Guan, Chao Ma, Yunpeng Zhang

J Pharm Biomed Anal· July 2020

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[Treatment efficacy of Solitaire stent- and LVIS stent-assisted coil embolization for intracranial wide-neck carotid aneurysm].
Yuanlai Liu, Yichun Sun, Yongchao He, Aiping Peng, Zhihu Yu, Qiyan Lin

Nan Fang Yi Ke Da Xue Xue Bao· March 2020

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Identification and characterization of forced degradation products and stability-indicating assay for notoginsenosidefc by using UHPLC-Q-TOF-MS and UHPLC-MS/MS: Insights into stability profile and degradation pathways.
Chao Ma, Huida Guan, Zhengcai Ju, Shuping Li, Gang Deng, Qiyan Lin

J Sep Sci· April 2019

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Analogous β-Carboline Alkaloids Harmaline and Harmine Ameliorate Scopolamine-Induced Cognition Dysfunction by Attenuating Acetylcholinesterase Activity, Oxidative Stress, and Inflammation in Mice.
Shu-Ping Li, Yu-Wen Wang, Sheng-Lan Qi, Yun-Peng Zhang, Gang Deng, Qi-Yan Lin

Front Pharmacol· April 2018

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Spongipyran Synthetic Studies. Total Synthesis of (+)-Spongistatin 2.
Amos B Smith, Qiyan Lin, Victoria A Doughty, Linghang Zhuang, Mark D McBriar

Tetrahedron· August 2009

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Enantioselective synthesis of Janus kinase inhibitor INCB018424 via an organocatalytic aza-Michael reaction.
Qiyan Lin, David Meloni, Yongchun Pan, Michael Xia, James Rodgers

Org Lett· May 2009

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Discovery of a potent, selective, and orally active human epidermal growth factor receptor-2 sheddase inhibitor for the treatment of cancer.
Wenqing Yao, Jincong Zhuo, David M Burns, Meizhong Xu, Colin Zhang, Lingkai Weng, Qiyan Lin

J Med Chem· February 2007

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Identification of ADAM10 as a major source of HER2 ectodomain sheddase activity in HER2 overexpressing breast cancer cells.
Phillip C C Liu, Xiangdong Liu, Yanlong Li, Maryanne Covington, Richard Wynn, Qiyan Lin, Colin Zhang, Lingkai Weng

Cancer Biol Ther· June 2006

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The Spongistatins: Architecturally Complex Natural Products-Part Two: Synthesis of the C(29-51) Subunit, Fragment Assembly, and Final Elaboration to (+)-Spongistatin 2.
Amos B Smith Iii, Qiyan Lin, Victoria A Doughty, Linghang Zhuang, Mark D McBriar

Angew Chem Int Ed Engl· January 2001

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The Spongistatins: Architecturally Complex Natural Products-Part One: A Formal Synthesis of (+)-Spongistatin 1 by Construction of an Advanced ABCD Fragment.
Amos B Smith Iii, Victoria A Doughty, Qiyan Lin, Linghang Zhuang, Mark D McBriar

Angew Chem Int Ed Engl· January 2001

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The Spongistatins: Architecturally Complex Natural Products-Part One: A Formal Synthesis of (+)-Spongistatin 1 by Construction of an Advanced ABCD Fragment Financial support was provided by the National Institutes of Health (National Cancer Institute) through Grant CA-70329, NIH Postdoctoral Fellowships to A.M.B. and W.H.M., a Japan Society for Promotion of Science Fellowship to N.M., and a Royal Society Fulbright Fellowship to V.A.D. We also thank the Daiichi Pharmaceutical Co., Ltd, and the Tanabe Seiyaku Co., Ltd for financial support. Finally we thank Dr. George T. Furst, Dr. Patrick J. Carroll, Dr. Rakesh Kohli, and Mr John Dykins of the University of Pennsylvania Spectroscopic Service Center for assistance in securing and interpreting high-field NMR spectra, X-ray crystal structures, and mass spectra.
Amos B. Smith III, Victoria A. Doughty, Qiyan Lin, Linghang Zhuang, Mark D. McBriar

Angew Chem Int Ed Engl· January 2001

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The Spongistatins: Architecturally Complex Natural Products-Part Two: Synthesis of the C(29-51) Subunit, Fragment Assembly, and Final Elaboration to (+)-Spongistatin 2 Financial support was provided by the National Institutes of Health (National Cancer Institute) through Grant CA-70329, a NIH Postdoctoral Fellowship to C.S.B., a Japan Society for Promotion of Science Fellowship to N.M., and a Royal Society Fulbright Fellowship to V.A.D. We also thank the Daiichi Pharmaceutical Co., Ltd, and the Tanabe Seiyaku Co., Ltd for financial support. Finally we thank Dr George T. Furst, Dr. Patrick J. Carroll, and Dr. Rakesh Kohli of the University of Pennsylvania Spectroscopic Service Center for assistance in securing and interpreting high-field NMR spectra, X-ray crystal structures, and mass spectra, respectively.
Amos B. Smith III, Qiyan Lin, Victoria A. Doughty, Linghang Zhuang, Mark D. McBriar

Angew Chem Int Ed Engl· January 2001

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