Publications by authors named "Raafat ElAwady"

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Opposing outcomes of short- and long-term epigenetic therapy in breast cancer: Implications for chemotherapy response.
Wafaa S Ramadan, Varsha Menon, Ragheb Alsheikh Zein, Sara Alqedra, Yahia El-Gharib

Biochem Pharmacol· January 2026

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Untargeted Multiomics of LNCaP Cell Line Treated with a Novel DNA Minor Groove Binder and/or Doxorubicin Using Mass Spectrometry.
Ruba A Zenati, Nelson C Soares, Hasan Y Alniss, Hamza M Al-Hroub, Raafat El-Awady

J Proteome Res· October 2025

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Further insights into the multitarget anticancer activity of tetrahydrocarbazole-1-amine/5-arylidene-4-thiazolinone based hybrids.
Basma S Ali, Anber F Mohammed, Varsha Menon, Wafaa S Ramadan, Claire Simons

Bioorg Chem· September 2025

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LncRNAs signatures in gynecological cancers: ovarian and endometrial cancers.
Salsabeel Elkholey, Yahia Elgharib, Raafat El-Awady, Ekram Saleh

Clin Transl Oncol· August 2025

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Design, Synthesis, and Anticancer Evaluation of Novel MGBs with Alkyne-Linked Thiazole Moieties.
Yousef A Msallam, Wafaa S Ramadan, Hadeel Al-Jubeh, Anil Ravi, Reem Sami Alhamidi

J Med Chem· July 2025

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Epigenetic therapeutics: reprogramming triple-negative breast cancer into responsive subtypes.
Wafaa S Ramadan, Aya Mudhafar Al-Azawi, Lama Lozon, Rawan R Kawaf, Ragheb Alsheikh Zein

Endocr Relat Cancer· July 2025

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Molecular signatures of xenograft colorectal cancer in mice treated with topotecan: A mass spectrometry-based study.
Yousra A Hagyousif, Ruba A Zenati, Nelson C Soares, Hamza M Al-Hroub, Farman Matloob Khan

Toxicol Rep· June 2025

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The histone acetyltransferase CBP participates in regulating the DNA damage response through ATM after double-strand breaks.
Wafaa S Ramadan, Samrein B M Ahmed, Iman M Talaat, Lama Lozon, Soraya Mouffak

Genome Biol· April 2025

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Metabolomic Analysis, Antiproliferative, Anti-Migratory, and Anti-Invasive Potential of Amlodipine in Lung Cancer Cells.
Mohammad A Y Alqudah, Mahmoud M Yaseen, Karem H Alzoubi, Belal A Al-Husein, Sanaa K Bardaweel

Drug Des Devel Ther· February 2025

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N-Substituted-5- [(2,5-Dihydroxybenzyl)amino]salicylamides as Lavendustin Analogs: Antiproliferative Activity, COMPARE Analyses, Mechanistic, Docking, ADMET and Toxicity Studies.
Hajjaj H M Abdu-Allah, Mohamed K S El-Nagar, Wesam S Qayed, Ola I A Salem, Abdel-Hamid N Kafafy

Chem Biol Drug Des· January 2025

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Tetrahydrocarbazoles incorporating 5-arylidene-4-thiazolinones as potential antileukemia and antilymphoma targeting tyrosine kinase and tubulin polymerase enzymes: Design, synthesis, structural, biological and molecular docking studies.
Basma S Ali, Anber F Mohammed, Benson M Kariuki, Raafat El-Awady, Hajjaj H M Abdu-Allah

Bioorg Chem· December 2024

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Combining lavendustin C and 5-arylidenethiazolin-4-one-based pharmacophores toward multitarget anticancer hybrids.
Shimaa A Othman, Ola F Abou-Ghadir, Varsha Menon, Wafaa S Ramadan, Yaser A Mostafa

Bioorg Chem· December 2024

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Impact of HDAC6-mediated progesterone receptor expression on the response of breast cancer cells to hormonal therapy.
Wafaa S Ramadan, Rahma K Alseksek, Soraya Mouffak, Iman M Talaat, Maha M Saber-Ayad

Eur J Pharmacol· November 2024

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Multi-omics analysis revealed significant metabolic changes in brain cancer cells treated with paclitaxel and/or topotecan.
Ahlam M Semreen, Leen Oyoun Alsoud, Mohammad H Semreen, Munazza Ahmed, Hamza M Al-Hroub

Heliyon· November 2024

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Transcriptomic analysis of MCF7 breast cancer cells treated with MGBs reveals a profound inhibition of estrogen receptor genes.
Hasan Y Alniss, Maha M Saber-Ayad, Wafaa S Ramadan, Poorna Manasa Bhamidimarri, Yousef A Msallam

Bioorg Chem· October 2024

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Decoding host cell interaction- and fluconazole-induced metabolic alterations and drug resistance in .
Samah H H Ismail, Rania Hamdy, Alaa M Altaie, Bahgat Fayed, Salam Dakalbab

Mycologia· September 2024

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Spectroscopic, biochemical and computational studies of bioactive DNA minor groove binders targeting 5'-WGWWCW-3' motif.
Hasan Y Alniss, Bryony M Kemp, Elizabeth Holmes, Joanna Hoffmann, Rafal M Ploch

Bioorg Chem· July 2024

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Author Correction: Targeting the DYRK1A kinase prevents cancer progression and metastasis and promotes cancer cells response to G1/S targeting chemotherapy drugs.
Amina Jamal Laham, Raafat El-Awady, Maha Saber-Ayad, Ni Wang, Gang Yan

NPJ Precis Oncol· July 2024

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Deciphering the interplay of histone post-translational modifications in cancer: Co-targeting histone modulators for precision therapy.
Rawan R Kawaf, Wafaa S Ramadan, Raafat El-Awady

Life Sci· June 2024

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Targeting the DYRK1A kinase prevents cancer progression and metastasis and promotes cancer cells response to G1/S targeting chemotherapy drugs.
Amina Jamal Laham, Raafat El-Awady, Maha Saber-Ayad, Ni Wang, Gang Yan

NPJ Precis Oncol· June 2024

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Decoding cell death signalling: Impact on the response of breast cancer cells to approved therapies.
Lama Lozon, Wafaa S Ramadan, Rawan R Kawaf, Aya M Al-Shihabi, Raafat El-Awady

Life Sci· April 2024

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Design, synthesis and mechanistic anticancer activity of new acetylated 5-aminosalicylate-thiazolinone hybrid derivatives.
Wafaa S Ramadan, Maha M Saber-Ayad, Ekram Saleh, Hajjaj H M Abdu-Allah, Abdel-Nasser A El-Shorbagi

iScience· January 2024

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Proteomic and metabolomic signatures of U87 glioblastoma cells treated with cisplatin and/or paclitaxel.
Munazza Ahmed, Ahlam M Semreen, Alexander D Giddey, Wafaa S Ramadan, Raafat El-Awady

Ann Med· January 2024

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Antimicrobial activity of nature-inspired molecules against multidrug-resistant bacteria.
Mohamad Hamad, Farah Al-Marzooq, Vunnam Srinivasulu, Ashna Sulaiman, Varsha Menon

Front Microbiol· January 2024

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The design, synthesis, biological evaluation, and molecular docking of new 5-aminosalicylamide-4-thiazolinone hybrids as anticancer agents.
Shimaa A Othman, Ola F Abou-Ghadir, Wafaa S Ramadan, Yaser A Mostafa, Raafat El-Awady

Arch Pharm (Weinheim)· October 2023

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