Publications by authors named "Rab Prinjha"

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Transcriptional derepression of negative regulators of MAP kinase supports maintenance of diapause ES cells in the pluripotent state.
Tuo Zhang, Ryan J Marina, Rab Prinjha, Karen Adelman, Alexander Tarakhovsky

Genes Dev· December 2025

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NLRP3 inflammasome-driven hemophagocytic lymphohistiocytosis occurs independent of IL-1β and IL-18 and is targetable by BET inhibitors.
Farzaneh Shojaee, Esmaeel Azadian, Min Xian Wong, Xiuquan Ma, James Rickard, Rab K Prinjha

Sci Adv· July 2025

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Acute resistance to BET inhibitors remodels compensatory transcriptional programs via p300 coactivation.
Viral Shah, George Giotopoulos, Hikari Osaki, Markus Meyerhöfer, Eshwar Meduri, Rab K Prinjha

Blood· February 2025

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mRNA export factors store nascent transcripts within nuclear speckles as an adaptive response to transient global inhibition of transcription.
Tobias D Williams, Ewa M Michalak, Kirstyn T Carey, Enid Y N Lam, Ashley Anderson, Rab K Prinjha

Mol Cell· January 2025

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Novel insights into the dynamic function of PRC2 in innate immunity.
Rosalie W M Kempkes, Rab K Prinjha, Menno P J de Winther, Annette E Neele

Trends Immunol· December 2024

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Integrated metabolic-transcriptomic network identifies immunometabolic modulations in human macrophages.
Hung-Jen Chen, Daniel C Sévin, Guillermo R Griffith, Johanna Vappiani, Lee M Booty, Rab K Prinjha

Cell Rep· September 2024

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Structure- and Property-Based Optimization of Efficient Pan-Bromodomain and Extra Terminal Inhibitors to Identify Oral and Intravenous Candidate I-BET787.
David J Hirst, Paul Bamborough, Niam Al-Mahdi, Davina C Angell, Heather A Barnett, Rab K Prinjha

J Med Chem· June 2024

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Structure-Guided Design of a Domain-Selective Bromodomain and Extra Terminal N-Terminal Bromodomain Chemical Probe.
Erin Bradley, Lucia Fusani, Chun-Wa Chung, Peter D Craggs, Emmanuel H Demont, Rab K Prinjha

J Med Chem· December 2023

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Design and Characterization of 1,3-Dihydro-2-benzo[]azepin-2-ones as Rule-of-5 Compliant Bivalent BET Inhibitors.
Paul Bamborough, Chun-Wa Chung, Nicole C Goodwin, Darren J Mitchell, Christopher E Neipp, Rab K Prinjha

ACS Med Chem Lett· September 2023

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In silico enhancer mining reveals SNS-032 and EHMT2 inhibitors as therapeutic candidates in high-grade serous ovarian cancer.
Marcos Quintela, David W James, Jetzabel Garcia, Kadie Edwards, Lavinia Margarit, Rab K Prinjha

Br J Cancer· July 2023

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The Epigenetic Reader Protein SP140 Regulates Dendritic Cell Activation, Maturation and Tolerogenic Potential.
Mohammed Ghiboub, Matthew Bell, Dovile Sinkeviciute, Rab K Prinjha, Menno P J de Winther

Curr Issues Mol Biol· May 2023

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Drug-induced loss of imprinting revealed using bioluminescent reporters of Cdkn1c.
Andrew Dimond, Mathew Van de Pette, Victoria Taylor-Bateman, Karen Brown, Alessandro Sardini, Rab K Prinjha

Sci Rep· April 2023

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Bromodomain inhibitor i-BET858 triggers a unique transcriptional response coupled to enhanced DNA damage, cell cycle arrest and apoptosis in high-grade ovarian carcinoma cells.
Marcos Quintela, David W James, Agne Pociute, Lydia Powell, Kadie Edwards, Rab K Prinjha

Clin Epigenetics· April 2023

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Endogenous bioluminescent reporters reveal a sustained increase in utrophin gene expression upon EZH2 and ERK1/2 inhibition.
Hannah J Gleneadie, Beatriz Fernandez-Ruiz, Alessandro Sardini, Mathew Van de Pette, Andrew Dimond, Rab K Prinjha

Commun Biol· March 2023

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Phase 1 and preclinical profiling of ESM-HDAC391, a myeloid-targeted histone deacetylase inhibitor, shows enhanced pharmacology and monocytopaenia.
Rebecca C Furze, Judit Molnar, Nigel J Parr, Faiz Ahmad, Yvette Henry, Rab K Prinjha

Br J Clin Pharmacol· December 2022

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Identification and Optimization of a Ligand-Efficient Benzoazepinone Bromodomain and Extra Terminal (BET) Family Acetyl-Lysine Mimetic into the Oral Candidate Quality Molecule I-BET432.
Philip G Humphreys, Niall A Anderson, Paul Bamborough, Andrew Baxter, Chun-Wa Chung, Rab K Prinjha

J Med Chem· November 2022

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terminal BET bromodomain inhibitors disrupt a BRD4-p65 interaction and reduce inducible nitric oxide synthase transcription in pancreatic β-cells.
Joshua A Nord, Sarah L Wynia-Smith, Alyssa L Gehant, Rachel A Jones Lipinski, Aaron Naatz, Rab K Prinjha

Front Endocrinol (Lausanne)· October 2022

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A BET Protein Inhibitor Targeting Mononuclear Myeloid Cells Affects Specific Inflammatory Mediators and Pathways in Crohn's Disease.
Ahmed M I Elfiky, Ishtu L Hageman, Marte A J Becker, Jan Verhoeff, Andrew Y F Li Yim, Rab K Prinjha

Cells· September 2022

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Modulation of macrophage inflammatory function through selective inhibition of the epigenetic reader protein SP140.
Mohammed Ghiboub, Jan Koster, Peter D Craggs, Andrew Y F Li Yim, Anthony Shillings, Rab K Prinjha

BMC Biol· August 2022

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Selective inhibitors of bromodomain BD1 and BD2 of BET proteins modulate radiation-induced profibrotic fibroblast responses.
Chun-Shan Liu, Inmaculada Rioja, Ali Bakr, Marlon R Veldwijk, Elena Sperk, Rab K Prinjha

Int J Cancer· July 2022

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Bromodomain factor 5 is an essential regulator of transcription in Leishmania.
Nathaniel G Jones, Vincent Geoghegan, Gareth Moore, Juliana B T Carnielli, Katherine Newling, Rab K Prinjha

Nat Commun· July 2022

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Cohesin couples transcriptional bursting probabilities of inducible enhancers and promoters.
Irene Robles-Rebollo, Sergi Cuartero, Adria Canellas-Socias, Sarah Wells, Mohammad M Karimi, Rab K Prinjha

Nat Commun· July 2022

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Essential Bromodomain BDF2 as a Drug Target against Chagas Disease.
Alejandro Pezza, Luis E Tavernelli, Victoria L Alonso, Virginia Perdomo, Raquel Gabarro, Rab Prinjha

ACS Infect Dis· May 2022

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Bromodomain Inhibitors Modulate FcγR-Mediated Mononuclear Phagocyte Activation and Chemotaxis.
Gemma D Banham, Colin Y C Lee, John R Ferdinand, Rebeccah J Matthews, Chenzhi Jing, Rab K Prinjha

Front Immunol· May 2022

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Combined noncanonical NF-κB agonism and targeted BET bromodomain inhibition reverse HIV latency ex vivo.
Shane D Falcinelli, Jackson J Peterson, Anne-Marie W Turner, David Irlbeck, Jenna Read, Rab K Prinjha

J Clin Invest· April 2022

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