Publications by authors named "Rachel Simmonds"

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Buruli ulcer.
Rie R Yotsu, Rachel E Simmonds, Dziedzom K de Souza, Richard Odame Phillips, Yaw Ampem Amoako

Nat Rev Dis Primers· December 2025

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Patients Having Major Abdominal Cancer Surgery Exhibit Significant Acute Muscle Wasting.
Gabor Dudas, Ismita Chhetri, Martin Whyte, Margaret Rayman, Rachel Simmonds

J Cachexia Sarcopenia Muscle· June 2025

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Micronutrient-deficient diets and possible environmental enteric dysfunction in Buruli ulcer endemic communities in Ghana: Lower dietary diversity and reduced serum zinc and vitamin C implicate micronutrient status a possible susceptibility factor.
Aloysius Dzigbordi Loglo, Philemon Boasiako Antwi, Kabiru Mohammed Abass, Samuel Osei-Mireku, George Amofa, Rachel E Simmonds

PLoS Negl Trop Dis· March 2025

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The toxin mycolactone causes destructive Sec61-dependent loss of the endothelial glycocalyx and vessel basement membrane to drive skin necrosis.
Louise Tzung-Harn Hsieh, Belinda S Hall, Jane Newcombe, Tom A Mendum, Sonia Santana Varela, Rachel E Simmonds

Elife· February 2025

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A systematic review and meta-analysis of the association between neglected tropical diseases and malnutrition: more research needed on diseases other than intestinal parasites, leishmaniasis and leprosy.
Aloysius Loglo, Wilfred Aniagyei, Monika Mira Vivekanandan, Abigail Agbanyo, Evans Adu Asamoah, Rachel E Simmonds

Access Microbiol· November 2024

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Mycolactone causes destructive Sec61-dependent loss of the endothelial glycocalyx and vessel basement membrane: a new indirect mechanism driving tissue necrosis in infection.
Louise Tzung-Harn Hsieh, Belinda S Hall, Jane Newcombe, Tom A Mendum, Sonia Santana-Varela, Rachel E Simmonds

bioRxiv· October 2024

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Multisensory medical illustrations of Buruli ulcer for improved disease detection, help seeking behaviour and adherence to treatment.
Joanna Butler, Jane Ogden, Richard Phillips, Roderick Hay, Rachel E Simmonds

J Vis Commun Med· January 2024

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Editorial: Host-pathogen interactions in nontuberculous mycobacterial infections.
Nicola Ivan Lorè, Sho Yamasaki, Rachel E Simmonds, Eun-Kyeong Jo

Front Immunol· June 2023

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Equine Arteritis Virus in Monocytic Cells Suppresses Differentiation and Function of Dendritic Cells.
Nathifa A Moyo, Dave Westcott, Rachel Simmonds, Falko Steinbach

Viruses· January 2023

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Synthesis, Biological Evaluation and Docking Studies of Ring-Opened Analogues of Ipomoeassin F.
Sarah O'Keefe, Pratiti Bhadra, Kwabena B Duah, Guanghui Zong, Levise Tenay, Rachel E Simmonds

Molecules· July 2022

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Inhibition of the SEC61 translocon by mycolactone induces a protective autophagic response controlled by EIF2S1-dependent translation that does not require ULK1 activity.
Belinda S Hall, Scott J Dos Santos, Louise Tzung-Harn Hsieh, Maria Manifava, Marie-Thérèse Ruf, Rachel E Simmonds

Autophagy· April 2022

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The One That Got Away: How Macrophage-Derived IL-1β Escapes the Mycolactone-Dependent Sec61 Blockade in Buruli Ulcer.
Belinda S Hall, Louise Tzung-Harn Hsieh, Sandra Sacre, Rachel E Simmonds

Front Immunol· February 2022

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Aberrant stromal tissue factor localisation and mycolactone-driven vascular dysfunction, exacerbated by IL-1β, are linked to fibrin formation in Buruli ulcer lesions.
Louise Tzung-Harn Hsieh, Scott J Dos Santos, Belinda S Hall, Joy Ogbechi, Aloysius D Loglo, Rachel E Simmonds

PLoS Pathog· January 2022

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Mycolactone enhances the Ca2+ leak from endoplasmic reticulum by trapping Sec61 translocons in a Ca2+ permeable state.
Pratiti Bhadra, Scott Dos Santos, Igor Gamayun, Tillman Pick, Clarissa Neumann, Rachel E Simmonds

Biochem J· November 2021

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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).
Daniel J Klionsky, Amal Kamal Abdel-Aziz, Sara Abdelfatah, Mahmoud Abdellatif, Asghar Abdoli, Rachel E Simmonds

Autophagy· January 2021

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Structure of the Inhibited State of the Sec Translocon.
Samuel F Gérard, Belinda S Hall, Afroditi M Zaki, Katherine A Corfield, Peter U Mayerhofer, Rachel E Simmonds

Mol Cell· August 2020

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Transient up-regulation of miR-155-3p by lipopolysaccharide in primary human monocyte-derived macrophages results in RISC incorporation but does not alter TNF expression.
Rachel E Simmonds

Wellcome Open Res· October 2019

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Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation.
Guanghui Zong, Zhijian Hu, Sarah O'Keefe, Dale Tranter, Michael J Iannotti, Rachel Simmonds

J Am Chem Soc· May 2019

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Buruli Ulcer: a Review of the Current Knowledge.
Rie R Yotsu, Koichi Suzuki, Rachel E Simmonds, Roger Bedimo, Anthony Ablordey

Curr Trop Med Rep· September 2018

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Inhibition of Sec61-dependent translocation by mycolactone uncouples the integrated stress response from ER stress, driving cytotoxicity via translational activation of ATF4.
Joy Ogbechi, Belinda S Hall, Thomas Sbarrato, Jack Taunton, Anne E Willis, Rachel E Simmonds

Cell Death Dis· March 2018

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Mycolactone reveals the substrate-driven complexity of Sec61-dependent transmembrane protein biogenesis.
Michael McKenna, Rachel E Simmonds, Stephen High

J Cell Sci· April 2017

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Mechanistic insights into the inhibition of Sec61-dependent co- and post-translational translocation by mycolactone.
Michael McKenna, Rachel E Simmonds, Stephen High

J Cell Sci· April 2016

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Recent advances: role of mycolactone in the pathogenesis and monitoring of Mycobacterium ulcerans infection/Buruli ulcer disease.
Fred Stephen Sarfo, Richard Phillips, Mark Wansbrough-Jones, Rachel E Simmonds

Cell Microbiol· January 2016

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Mycolactone-Dependent Depletion of Endothelial Cell Thrombomodulin Is Strongly Associated with Fibrin Deposition in Buruli Ulcer Lesions.
Joy Ogbechi, Marie-Thérèse Ruf, Belinda S Hall, Katherine Bodman-Smith, Moritz Vogel, Rachel E Simmonds

PLoS Pathog· July 2015

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The pathogenic mechanism of the Mycobacterium ulcerans virulence factor, mycolactone, depends on blockade of protein translocation into the ER.
Belinda S Hall, Kirsti Hill, Michael McKenna, Joy Ogbechi, Stephen High, Rachel E Simmonds

PLoS Pathog· April 2014

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