Publications by authors named "Rachele Bellini"

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Analysis of Oral and Gut Microbiota Composition in Children with Dental Caries by NGS Approaches.
Stefano Cianetti, Silvia Marchianò, Dhanushka Frank Wijeratne, Adriana Carino, Michele Biagioli, Rachele Bellini

Recent Adv Inflamm Allergy Drug Discov· December 2025

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Allo-lithocholic acid, a microbiome derived secondary bile acid, attenuates liver fibrosis.
Silvia Marchianò, Michele Biagioli, Cristina Di Giorgio, Carmen Massa, Rachele Bellini

Biochem Pharmacol· June 2025

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Liver GPBAR1 Associates With Immune Dysfunction in Primary Sclerosing Cholangitis and Its Activation Attenuates Cholestasis in Abcb4-/- Mice.
Cristina Di Giorgio, Ginevra Urbani, Silvia Marchianò, Michele Biagioli, Martina Bordoni, Rachele Bellini

Liver Int· February 2025

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Microbial-derived bile acid reverses inflammation in IBD via GPBAR1 agonism and RORγt inverse agonism.
Michele Biagioli, Cristina Di Giorgio, Carmen Massa, Silvia Marchianò, Rachele Bellini

Biomed Pharmacother· December 2024

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Development of dual GPBAR1 agonist and RORγt inverse agonist for the treatment of inflammatory bowel diseases.
Michele Biagioli, Cristina Di Giorgio, Elva Morretta, Rachele Bellini, Carmen Massa

Pharmacol Res· October 2024

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Bile acids serve as endogenous antagonists of the Leukemia inhibitory factor (LIF) receptor in oncogenesis.
Cristina Di Giorgio, Elva Morretta, Antonio Lupia, Rachele Bellini, Carmen Massa

Biochem Pharmacol· May 2024

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The leukemia inhibitory factor regulates fibroblast growth factor receptor 4 transcription in gastric cancer.
Cristina Di Giorgio, Rachele Bellini, Antonio Lupia, Carmen Massa, Ginevra Urbani

Cell Oncol (Dordr)· April 2024

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Activation of GPBAR1 attenuates vascular inflammation and atherosclerosis in a mouse model of NAFLD-related cardiovascular disease.
Michele Biagioli, Silvia Marchianò, Cristina Di Giorgio, Martina Bordoni, Ginevra Urbani, Rachele Bellini

Biochem Pharmacol· December 2023

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Defective Bile Acid Signaling Promotes Vascular Dysfunction, Supporting a Role for G-Protein Bile Acid Receptor 1/Farnesoid X Receptor Agonism and Statins in the Treatment of Nonalcoholic Fatty Liver Disease.
Silvia Marchianò, Michele Biagioli, Martina Bordoni, Elva Morretta, Cristina Di Giorgio, Rachele Bellini

J Am Heart Assoc· December 2023

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Correction to "Discovery of a Novel Class of Dual GPBAR1 Agonists-RORγt Inverse Agonists for the Treatment of IL-17-Mediated Disorders".
Bianca Fiorillo, Rosalinda Roselli, Claudia Finamore, Michele Biagioli, Cristina di Giorgio, Rachele Bellini

ACS Omega· November 2023

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Combinatorial targeting of G-protein-coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug-induced liver injury.
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini

Hepatology· July 2023

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Discovery of BAR502, as potent steroidal antagonist of leukemia inhibitory factor receptor for the treatment of pancreatic adenocarcinoma.
Cristina Di Giorgio, Rachele Bellini, Antonio Lupia, Carmen Massa, Martina Bordoni

Front Oncol· March 2023

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Discovery of a Novel Class of Dual GPBAR1 Agonists-RORγt Inverse Agonists for the Treatment of IL-17-Mediated Disorders.
Bianca Fiorillo, Rosalinda Roselli, Claudia Finamore, Michele Biagioli, Cristina di Giorgio, Rachele Bellini

ACS Omega· February 2023

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Combinatorial therapy with BAR502 and UDCA resets FXR and GPBAR1 signaling and reverses liver histopathology in a model of NASH.
Silvia Marchianò, Michele Biagioli, Elva Morretta, Cristina Di Giorgio, Rosalinda Roselli, Rachele Bellini

Sci Rep· January 2023

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Beneficial effects of UDCA and norUDCA in a rodent model of steatosis are linked to modulation of GPBAR1/FXR signaling.
Silvia Marchianò, Michele Biagioli, Rosalinda Roselli, Angela Zampella, Cristina Di Giorgio, Rachele Bellini

Biochim Biophys Acta Mol Cell Biol Lipids· November 2022

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Repositioning Mifepristone as a Leukaemia Inhibitory Factor Receptor Antagonist for the Treatment of Pancreatic Adenocarcinoma.
Cristina Di Giorgio, Antonio Lupia, Silvia Marchianò, Martina Bordoni, Rachele Bellini

Cells· November 2022

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Next-Generation Sequencing Analysis of Gastric Cancer Identifies the Leukemia Inhibitory Factor Receptor as a Driving Factor in Gastric Cancer Progression and as a Predictor of Poor Prognosis.
Cristina Di Giorgio, Silvia Marchianò, Elisabetta Marino, Michele Biagioli, Rosalinda Roselli, Rachele Bellini

Front Oncol· June 2022

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GLP-1 Mediates Regulation of Colonic ACE2 Expression by the Bile Acid Receptor GPBAR1 in Inflammation.
Michele Biagioli, Silvia Marchianò, Rosalinda Roselli, Cristina Di Giorgio, Rachele Bellini

Cells· April 2022

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Discovery of a Potent and Orally Active Dual GPBAR1/CysLTR Modulator for the Treatment of Metabolic Fatty Liver Disease.
Stefano Fiorucci, Pasquale Rapacciuolo, Bianca Fiorillo, Rosalinda Roselli, Silvia Marchianò, Rachele Bellini

Front Pharmacol· April 2022

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Atorvastatin protects against liver and vascular damage in a model of diet induced steatohepatitis by resetting FXR and GPBAR1 signaling.
Silvia Marchianò, Michele Biagioli, Rosalinda Roselli, Angela Zampella, Cristina Di Giorgio, Rachele Bellini

FASEB J· January 2022

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Discovery of a AHR pelargonidin agonist that counter-regulates Ace2 expression and attenuates ACE2-SARS-CoV-2 interaction.
Michele Biagioli, Silvia Marchianò, Rosalinda Roselli, Cristina Di Giorgio, Rachele Bellini

Biochem Pharmacol· June 2021

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