Publications by authors named "Radek Indra"

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The relationship between cancer risk and cystic fibrosis: the role of CFTR in cell growth and cancer development.
Radek Indra, Věra Černá

RSC Med Chem· August 2025

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The tyrosine kinase inhibitor lenvatinib is oxidized by rat cytochromes P450 and affects their expression in rat liver.
Radek Indra, Sandra Jelínková, Katarína Kollárová, Petra Zahumenská, Josef Dvořák

Acta Pharm· September 2024

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The impact of individual human cytochrome P450 enzymes on oxidative metabolism of anticancer drug lenvatinib.
Katarína Vavrová, Radek Indra, Petr Pompach, Zbyněk Heger, Petr Hodek

Biomed Pharmacother· January 2022

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Benzo[]pyrene-Induced Genotoxicity in Rats Is Affected by Co-Exposure to Sudan I by Altering the Expression of Biotransformation Enzymes.
Helena Dračínská, Radek Indra, Sandra Jelínková, Věra Černá, Volker Manfred Arlt

Int J Mol Sci· July 2021

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Apoferritin/Vandetanib Association Is Long-Term Stable But Does Not Improve Pharmacological Properties of Vandetanib.
Kateřina Jáklová, Tereza Feglarová, Simona Rex, Zbyněk Heger, Tomáš Eckschlager, Radek Indra

Int J Mol Sci· April 2021

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Identification of Enzymes Oxidizing the Tyrosine Kinase Inhibitor Cabozantinib: Cabozantinib Is Predominantly Oxidized by CYP3A4 and Its Oxidation Is Stimulated by cyt b Activity.
Radek Indra, Katarína Vavrová, Petr Pompach, Zbyněk Heger, Petr Hodek

Biomedicines· November 2020

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Cytochrome P450 and flavin-containing monooxygenase enzymes are responsible for differential oxidation of the anti-thyroid-cancer drug vandetanib by human and rat hepatic microsomal systems.
Radek Indra, Petr Pompach, Katarína Vavrová, Kateřina Jáklová, Zbyněk Heger

Environ Toxicol Pharmacol· February 2020

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The impact of p53 on aristolochic acid I-induced nephrotoxicity and DNA damage in vivo and in vitro.
Mateja Sborchia, Eric G De Prez, Marie-Hélène Antoine, Lucie Bienfait, Radek Indra

Arch Toxicol· November 2019

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Identification of Human Enzymes Oxidizing the Anti-Thyroid-Cancer Drug Vandetanib and Explanation of the High Efficiency of Cytochrome P450 3A4 in its Oxidation.
Radek Indra, Petr Pompach, Václav Martínek, Paulína Takácsová, Katarína Vavrová

Int J Mol Sci· July 2019

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Ellipticine-loaded apoferritin nanocarrier retains DNA adduct-based cytochrome P450-facilitated toxicity in neuroblastoma cells.
Radek Indra, Tereza Černá, Zbyněk Heger, Jan Hraběta, Marek Wilhelm

Toxicology· May 2019

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Application of hepatic cytochrome b/P450 reductase null (HBRN) mice to study the role of cytochrome b in the cytochrome P450-mediated bioactivation of the anticancer drug ellipticine.
Lindsay Reed, Radek Indra, Iveta Mrizova, Michaela Moserova, Heinz H Schmeiser

Toxicol Appl Pharmacol· March 2019

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Tyrosine kinase inhibitors vandetanib, lenvatinib and cabozantinib modulate oxidation of an anticancer agent ellipticine catalyzed by cytochromes P450 in vitro.
Matus Kolarik, Radek Indra, Vojtech Adam, Zbynek Heger, Katerina Kopeckova

Neuro Endocrinol Lett· February 2019

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Differentiation-associated urothelial cytochrome P450 oxidoreductase predicates the xenobiotic-metabolizing activity of "luminal" muscle-invasive bladder cancers.
Simon C Baker, Volker M Arlt, Radek Indra, Madeleine Joel, Marie Stiborová

Mol Carcinog· May 2018

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Cytochrome b impacts on cytochrome P450-mediated metabolism of benzo[a]pyrene and its DNA adduct formation: studies in hepatic cytochrome b /P450 reductase null (HBRN) mice.
Lindsay Reed, Iveta Mrizova, Frantisek Barta, Radek Indra, Michaela Moserova

Arch Toxicol· April 2018

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The impact of chemotherapeutic drugs on the CYP1A1-catalysed metabolism of the environmental carcinogen benzo[a]pyrene: Effects in human colorectal HCT116 TP53(+/+), TP53(+/-) and TP53(-/-) cells.
Alexandra J Willis, Radek Indra, Laura E Wohak, Osman Sozeri, Kerstin Feser

Toxicology· April 2018

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Comparison of human cytochrome P450 1A1-catalysed oxidation of benzo[]pyrene in prokaryotic and eukaryotic expression systems.
Marie Stiborová, Radek Indra, Michaela Moserová, Lucie Bořek-Dohalská, Petr Hodek

Monatsh Chem· July 2017

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Cytochrome plays a dual role in the reaction cycle of cytochrome P450 3A4 during oxidation of the anticancer drug ellipticine.
Marie Stiborová, Radek Indra, Eva Frei, Kateřina Kopečková, Heinz H Schmeiser

Monatsh Chem· July 2017

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Correction to NADH:Cytochrome b5 Reductase and Cytochrome b5 Can Act as Sole Electron Donors to Human Cytochrome P450 1A1-Mediated Oxidation and DNA Adduct Formation by Benzo[a]pyrene.
Marie Stiborová, Radek Indra, Michaela Moserová, Eva Frei, Heinz H Schmeiser

Chem Res Toxicol· September 2016

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NADH:Cytochrome b5 Reductase and Cytochrome b5 Can Act as Sole Electron Donors to Human Cytochrome P450 1A1-Mediated Oxidation and DNA Adduct Formation by Benzo[a]pyrene.
Marie Stiborová, Radek Indra, Michaela Moserová, Eva Frei, Heinz H Schmeiser

Chem Res Toxicol· August 2016

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The impact of p53 on DNA damage and metabolic activation of the environmental carcinogen benzo[a]pyrene: effects in Trp53(+/+), Trp53(+/-) and Trp53(-/-) mice.
Annette M Krais, Ewoud N Speksnijder, Joost P M Melis, Radek Indra, Michaela Moserova

Arch Toxicol· April 2016

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The impact of individual cytochrome P450 enzymes on oxidative metabolism of benzo[a]pyrene in human livers.
Miroslav Šulc, Radek Indra, Michaela Moserová, Heinz H Schmeiser, Eva Frei

Environ Mol Mutagen· April 2016

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NADPH- and NADH-dependent metabolism of and DNA adduct formation by benzo[]pyrene catalyzed with rat hepatic microsomes and cytochrome P450 1A1.
Marie Stiborová, Radek Indra, Michaela Moserová, Miroslav Šulc, Petr Hodek

Monatsh Chem· March 2016

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Induced expression of microsomal cytochrome determined at mRNA and protein levels in rats exposed to ellipticine, benzo[]pyrene, and 1-phenylazo-2-naphthol (Sudan I).
Marie Stiborová, Michaela Moserová, Iveta Mrízová, Helena Dračínská, Václav Martínek, Radek Indra

Monatsh Chem· January 2016

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Modulation of human cytochrome P450 1A1-mediated oxidation of benzo[a]pyrene by NADPH:cytochrome P450 oxidoreductase and cytochrome b5.
Radek Indra, Michaela Moserova, Natalie Kroftova, Miroslav Sulc, Marketa Martinkova

Neuro Endocrinol Lett· August 2015

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Cytochrome b5 and epoxide hydrolase contribute to benzo[a]pyrene-DNA adduct formation catalyzed by cytochrome P450 1A1 under low NADPH:P450 oxidoreductase conditions.
Marie Stiborová, Michaela Moserová, Věra Černá, Radek Indra, Martin Dračínský

Toxicology· April 2014

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