Publications by authors named "Rajakrishnan Veluthakal"

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TAS1R3 regulates GTPase signaling in human skeletal muscle cells for glucose uptake.
Joseph M Hoolachan, Rekha Balakrishnan, Karla E Merz, Debbie C Thurmond, Rajakrishnan Veluthakal

bioRxiv· November 2025

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Mitochondrial Dysfunction, Oxidative Stress, and Inter-Organ Miscommunications in T2D Progression.
Rajakrishnan Veluthakal, Diana Esparza, Joseph M Hoolachan, Rekha Balakrishnan, Miwon Ahn

Int J Mol Sci· January 2024

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A Novel Role for DOC2B in Ameliorating Palmitate-Induced Glucose Uptake Dysfunction in Skeletal Muscle Cells via a Mechanism Involving β-AR Agonism and Cofilin.
Jinhee Hwang, Rekha Balakrishnan, Eunjin Oh, Rajakrishnan Veluthakal, Debbie C Thurmond

Int J Mol Sci· December 2023

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Toward Ameliorating Insulin Resistance: Targeting a Novel PAK1 Signaling Pathway Required for Skeletal Muscle Mitochondrial Function.
Rekha Balakrishnan, Pablo A Garcia, Rajakrishnan Veluthakal, Janice M Huss, Joseph M Hoolachan

Antioxidants (Basel)· August 2023

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Architecture of androgen receptor pathways amplifying glucagon-like peptide-1 insulinotropic action in male pancreatic β cells.
Weiwei Xu, M M Fahd Qadir, Daniela Nasteska, Paula Mota de Sa, Caroline M Gorvin, Rajakrishnan Veluthakal

Cell Rep· May 2023

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Changes in Skeletal Muscle PAK1 Levels Regulate Tissue Crosstalk to Impact Whole Body Glucose Homeostasis.
Karla E Merz, Ragadeepthi Tunduguru, Miwon Ahn, Vishal A Salunkhe, Rajakrishnan Veluthakal

Front Endocrinol (Lausanne)· March 2022

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Enrichment of the exocytosis protein STX4 in skeletal muscle remediates peripheral insulin resistance and alters mitochondrial dynamics via Drp1.
Karla E Merz, Jinhee Hwang, Chunxue Zhou, Rajakrishnan Veluthakal, Erika M McCown

Nat Commun· January 2022

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Emerging Roles of Small GTPases in Islet β-Cell Function.
Rajakrishnan Veluthakal, Debbie C Thurmond

Cells· June 2021

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Syntaxin 4 Mediates NF-κB Signaling and Chemokine Ligand Expression via Specific Interaction With IκBβ.
Rajakrishnan Veluthakal, Eunjin Oh, Miwon Ahn, Diti Chatterjee Bhowmick, Debbie C Thurmond

Diabetes· April 2021

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A requirement for PAK1 to support mitochondrial function and maintain cellular redox balance via electron transport chain proteins to prevent β-cell apoptosis.
Miwon Ahn, Eunjin Oh, Erika M McCown, Xin Wang, Rajakrishnan Veluthakal

Metabolism· February 2021

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Conventional and Unconventional Mechanisms by which Exocytosis Proteins Oversee β-cell Function and Protection.
Diti Chatterjee Bhowmick, Miwon Ahn, Eunjin Oh, Rajakrishnan Veluthakal, Debbie C Thurmond

Int J Mol Sci· February 2021

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DOC2B promotes insulin sensitivity in mice via a novel KLC1-dependent mechanism in skeletal muscle.
Jing Zhang, Eunjin Oh, Karla E Merz, Arianne Aslamy, Rajakrishnan Veluthakal

Diabetologia· May 2019

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Restoration of Glucose-Stimulated Cdc42-Pak1 Activation and Insulin Secretion by a Selective Epac Activator in Type 2 Diabetic Human Islets.
Rajakrishnan Veluthakal, Oleg G Chepurny, Colin A Leech, Frank Schwede, George G Holz

Diabetes· October 2018

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Novel approaches to restore beta cell function in prediabetes and type 2 diabetes.
Vishal A Salunkhe, Rajakrishnan Veluthakal, Steven E Kahn, Debbie C Thurmond

Diabetologia· September 2018

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Doc2b Protects β-Cells Against Inflammatory Damage and Enhances Function.
Arianne Aslamy, Eunjin Oh, Erika M Olson, Jing Zhang, Miwon Ahn, Rajakrishnan Veluthakal

Diabetes· July 2018

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NSC23766, a Known Inhibitor of Tiam1-Rac1 Signaling Module, Prevents the Onset of Type 1 Diabetes in the NOD Mouse Model.
Rajakrishnan Veluthakal, Vaibhav Sidarala, Anjaneyulu Kowluru

Cell Physiol Biochem· February 2017

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Metabolic Stress Induces Caspase-3 Mediated Degradation and Inactivation of Farnesyl and Geranylgeranyl Transferase Activities in Pancreatic β-Cells.
Rajakrishnan Veluthakal, Daleep K Arora, Marc L Goalstone, Renu A Kowluru, Anjaneyulu Kowluru

Cell Physiol Biochem· February 2017

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Tiam1-Rac1 Axis Promotes Activation of p38 MAP Kinase in the Development of Diabetic Retinopathy: Evidence for a Requisite Role for Protein Palmitoylation.
Rajakrishnan Veluthakal, Binit Kumar, Ghulam Mohammad, Anjaneyulu Kowluru, Renu A Kowluru

Cell Physiol Biochem· February 2016

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VAV2, a guanine nucleotide exchange factor for Rac1, regulates glucose-stimulated insulin secretion in pancreatic beta cells.
Rajakrishnan Veluthakal, Ragadeepthi Tunduguru, Daleep Kumar Arora, Vaibhav Sidarala, Khadija Syeda

Diabetologia· November 2015

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EHT 1864, a small molecule inhibitor of Ras-related C3 botulinum toxin substrate 1 (Rac1), attenuates glucose-stimulated insulin secretion in pancreatic β-cells.
Vaibhav Sidarala, Rajakrishnan Veluthakal, Khadija Syeda, Anjaneyulu Kowluru

Cell Signal· June 2015

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Phagocyte-like NADPH oxidase (Nox2) promotes activation of p38MAPK in pancreatic β-cells under glucotoxic conditions: Evidence for a requisite role of Ras-related C3 botulinum toxin substrate 1 (Rac1).
Vaibhav Sidarala, Rajakrishnan Veluthakal, Khadija Syeda, Cornelis Vlaar, Philip Newsholme

Biochem Pharmacol· June 2015

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Glucotoxic and diabetic conditions induce caspase 6-mediated degradation of nuclear lamin A in human islets, rodent islets and INS-1 832/13 cells.
Syeda Khadija, Rajakrishnan Veluthakal, Vaibhav Sidarala, Anjaneyulu Kowluru

Apoptosis· December 2014

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TIAM1-RAC1 signalling axis-mediated activation of NADPH oxidase-2 initiates mitochondrial damage in the development of diabetic retinopathy.
Renu A Kowluru, Anjaneyulu Kowluru, Rajakrishnan Veluthakal, Ghulam Mohammad, Ismail Syed

Diabetologia· May 2014

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Nm23-H1 regulates glucose-stimulated insulin secretion in pancreatic β-cells via Arf6-Rac1 signaling axis.
Rajakrishnan Veluthakal, David Kaetzel, Anjaneyulu Kowluru

Cell Physiol Biochem· April 2014

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In vivo beta-cell imaging with VMAT 2 ligands--current state-of-the-art and future perspective.
Rajakrishnan Veluthakal, Paul Harris

Curr Pharm Des· May 2010

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