Publications by authors named "Rajeeva Singh"

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Correlating high concentration behavior of commercial or clinical-stage monoclonal and bispecific antibodies with miniaturized polyethylene glycol precipitation assay.
Sadisna Shahi, Mahsa Azami, Richa Garg, Rajeeva Singh, Chen Zhou

J Pharm Sci· November 2025

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Severe nutritional anaemia in Yorkshire and the Humber following the COVID-19 pandemic: no room for complacency.
Kate Frances Parmenter, Emma Gamwell, Sal Katib, Emma McCabe, Maria Mcphee, Rajeeva Singh

Arch Dis Child· October 2025

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Limitation of anion exchange chromatography and potential application of hydrophobic interaction chromatography for monitoring AAV9 capsid degradation upon thermal stress.
Antonela Rodriguez, Ali Banazadeh, Amr Ali, Rajeeva Singh, Chen Zhou

J Pharm Sci· February 2025

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In vitro Stability Study of a Panel of Commercial Antibodies at Physiological pH and Temperature as a Guide to Screen Biologic Candidate Molecules for the Potential Risk of In vivo Asparagine Deamidation and Activity Loss.
Richa Garg, Sean McCarthy, Alayna George Thompson, Jiang Zhang, Emily Mattson, Rajeeva Singh

Pharm Res· February 2025

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Insight Into the Degradation Pathways of an AAV9.
Antonela Rodriguez, Supriya Jalimarada-Shivakumar, Ali Banazadeh, Sharmin Afroz, Amr Ali, Rajeeva Singh

J Pharm Sci· September 2024

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IL11-mediated stromal cell activation may not be the master regulator of pro-fibrotic signaling downstream of TGFβ.
Yunhao Tan, Kenta Mosallanejad, Qingxiu Zhang, Stephen O'Brien, Meghan Clements, Gurminder Singh, Rajeeva Singh

Front Immunol· March 2024

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Increased incidence of severe nutritional anaemia in Yorkshire and Humber during the COVID-19 pandemic with critical clinical decompensation.
Kate Parmenter, Andrew Brookes, Sarah Burn, Emma Gamwell, Peter Jenkins, Rajeeva Singh

Arch Dis Child· December 2021

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Antibody-Drug Conjugates with Indolinobenzodiazepine Dimer Payloads: DNA-Binding Mechanism of Indolinobenzodiazepine Dimer Catabolites in Target Cancer Cells.
Rajeeva Singh, Emily E Reid, Luke Harris, Paulin L Salomon, Michael L Miller

Mol Pharm· January 2020

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Optimizing Lysosomal Activation of Antibody-Drug Conjugates (ADCs) by Incorporation of Novel Cleavable Dipeptide Linkers.
Paulin L Salomon, Emily E Reid, Katie E Archer, Luke Harris, Erin K Maloney, Rajeeva Singh

Mol Pharm· December 2019

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Synthesis of Highly Potent N-10 Amino-Linked DNA-Alkylating Indolinobenzodiazepine Antibody-Drug Conjugates (ADCs).
Katie E Archer, Emily E Reid, Manami Shizuka, James Woods, Luke Harris, Rajeeva Singh

ACS Med Chem Lett· August 2019

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A DNA-Interacting Payload Designed to Eliminate Cross-Linking Improves the Therapeutic Index of Antibody-Drug Conjugates (ADCs).
Michael L Miller, Manami Shizuka, Alan Wilhelm, Paulin Salomon, Emily E Reid, Rajeeva Singh

Mol Cancer Ther· March 2018

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A New Class of Antibody-Drug Conjugates with Potent DNA Alkylating Activity.
Michael L Miller, Nathan E Fishkin, Wei Li, Kathleen R Whiteman, Yelena Kovtun, Rajeeva Singh

Mol Cancer Ther· August 2016

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A New Triglycyl Peptide Linker for Antibody-Drug Conjugates (ADCs) with Improved Targeted Killing of Cancer Cells.
Rajeeva Singh, Yulius Y Setiady, Jose Ponte, Yelena V Kovtun, Katharine C Lai

Mol Cancer Ther· June 2016

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Development of Anilino-Maytansinoid ADCs that Efficiently Release Cytotoxic Metabolites in Cancer Cells and Induce High Levels of Bystander Killing.
Wayne C Widdison, Jose F Ponte, Jennifer A Coccia, Leanne Lanieri, Yulius Setiady, Rajeeva Singh

Bioconjug Chem· November 2015

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IMGN853, a Folate Receptor-α (FRα)-Targeting Antibody-Drug Conjugate, Exhibits Potent Targeted Antitumor Activity against FRα-Expressing Tumors.
Olga Ab, Kathleen R Whiteman, Laura M Bartle, Xiuxia Sun, Rajeeva Singh

Mol Cancer Ther· July 2015

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Sensitive ELISA Method for the Measurement of Catabolites of Antibody-Drug Conjugates (ADCs) in Target Cancer Cells.
Paulin L Salomon, Rajeeva Singh

Mol Pharm· June 2015

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A novel pathway for maytansinoid release from thioether linked antibody-drug conjugates (ADCs) under oxidative conditions.
Nathan Fishkin, Erin K Maloney, Ravi V J Chari, Rajeeva Singh

Chem Commun (Camb)· October 2011

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Synthesis and evaluation of hydrophilic linkers for antibody-maytansinoid conjugates.
Robert Y Zhao, Sharon D Wilhelm, Charlene Audette, Gregory Jones, Barbara A Leece, Rajeeva Singh

J Med Chem· May 2011

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Design of antibody-maytansinoid conjugates allows for efficient detoxification via liver metabolism.
Xiuxia Sun, Wayne Widdison, Michele Mayo, Sharon Wilhelm, Barbara Leece, Rajeeva Singh

Bioconjug Chem· April 2011

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Disulfide-linked antibody-maytansinoid conjugates: optimization of in vivo activity by varying the steric hindrance at carbon atoms adjacent to the disulfide linkage.
Brenda A Kellogg, Lisa Garrett, Yelena Kovtun, Katharine C Lai, Barbara Leece, Rajeeva Singh

Bioconjug Chem· April 2011

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Antibody-maytansinoid conjugates designed to bypass multidrug resistance.
Yelena V Kovtun, Charlene A Audette, Michele F Mayo, Gregory E Jones, Heather Doherty, Rajeeva Singh

Cancer Res· March 2010

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Tumor delivery and in vivo processing of disulfide-linked and thioether-linked antibody-maytansinoid conjugates.
Hans K Erickson, Wayne C Widdison, Michele F Mayo, Kathleen Whiteman, Charlene Audette, Rajeeva Singh

Bioconjug Chem· January 2010

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Antibody-cytotoxic agent conjugates: preparation and characterization.
Rajeeva Singh, Hans K Erickson

Methods Mol Biol· April 2009

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Targeting of insulin-like growth factor-I receptor with a monoclonal antibody inhibits growth of hepatic metastases from human colon carcinoma in mice.
Todd W Bauer, Fan Fan, Wenbiao Liu, Ernest R Camp, Anthony Yang, Rajeeva Singh

Ann Surg Oncol· October 2007

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Head cooling for exercise-induced headache.
Rajeeva Kumar Singh, Adelaida Martinez, Peter Baxter

J Child Neurol· December 2006

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