Publications by authors named "Rajesh Chavan"

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Pharmacokinetics and Penetration of a Novel Pharmacodynamically Optimized, Carbapenem-Sparing Antibiotic, WCK 4282 (Cefepime/Tazobactam), into Epithelial Lining Fluid of Healthy, Lung-, and Thigh-Infected Neutropenic Mice.
Rajesh Chavan, Vineet Zope, Kiran Patil, Swapna Takalkar, Pavan Tayde

Microb Drug Resist· October 2025

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Efficacy and safety of a 3-day once-daily regimen of oral nafithromycin in comparison to oral moxifloxacin for the treatment of community-acquired bacterial pneumonia in adults: a phase III, randomized, double-blind controlled trial.
Himanshu Pophale, Monica Gupta, Lily Llorens, Piotr Iwanowski, Ranjeet Gutte, Rajesh Chavan

Lancet Reg Health Southeast Asia· October 2025

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Serum Pharmacokinetics and Bone Penetration of Novel Broad-Spectrum Anti-MRSA Agent Levonadifloxacin in Wistar Rats.
Rajesh Chavan, Vineet Zope, Avinash Karade, Manohar Nandanwar, Sachin Bhagwat

Microb Drug Resist· November 2024

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Investigations on Pharmacokinetic/Pharmacodynamic Determinants of Fosfomycin in Murine Thigh and Kidney Infection Models.
Rajesh Chavan, Bhushan Naphade, Bhalchandra Waykar, Sachin Bhagwat

Microb Drug Resist· January 2023

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Cefepime pharmacodynamic targets against Enterobacterales employing neutropenic murine lung infection and in vitro pharmacokinetic models.
Anouk E Muller, Marie Attwood, Sanne Van den Berg, Rajesh Chavan, Hariharan Periasamy

J Antimicrob Chemother· November 2022

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WCK 4034: A promising oxazolidinone for treating gram positive infections.
Satish Bhawsar, Shivaji Pawar, Prasad Deshpande, Ravindra Yeole, Rajesh Chavan

Bioorg Med Chem Lett· September 2022

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Simultaneous determination of novel β-lactamase inhibitor WCK 4234 and Meropenem in dog plasma by LC-MS/MS and its application to preclinical pharmacokinetic study.
Kiran Patil, Amin Pathan, Sukanta Naik, Vineet Zope, Rajesh Chavan

Biomed Chromatogr· July 2022

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Preclinical safety evaluation of nafithromycin (WCK 4873) with emphasis on liver safety in rat and dog.
Manohar Nandanwar, Rajesh Chavan, Atul Kansagara, Muftedar Ahmed Patel, Anasuya Patel

Regul Toxicol Pharmacol· June 2021

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Activity of Fosfomycin and Nitrofurantoin Against Contemporary Pathogens Isolated from Indian Tertiary Care Hospitals.
Rajesh Chavan, Bhushan Naphade, Bhalchandra Waykar, Sachin Bhagwat

Microb Drug Resist· May 2021

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Assessment of the cytochrome P450 (CYP) inhibition potential of nafithromycin, a next generation lactone ketolide antibiotic.
Rajesh Chavan, Vineet Zope, Nilesh Chavan, Kiran Patil, Ravindra Yeole

Xenobiotica· March 2021

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Assessment of inhibitory effects of novel anti MRSA benzoquinolizine fluoroquinolone WCK 771 (levonadifloxacin) and its metabolite on human liver cytochrome P450 enzymes.
Rajesh Chavan, Vineet Zope, Nilesh Chavan, Javeed Shaikh, Kiran Patil

Xenobiotica· October 2020

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"OPD TRIAGE" - A novel concept for better patient management in heavily loaded orthopaedic OPDs.
Nishant D Goyal, Rajesh Kumar Chavan, Anshul Pahwa, Vinay Kumar Gautam, Neeraj Mishra

J Clin Orthop Trauma· July 2020

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Levonadifloxacin, a Novel Broad-Spectrum Anti-MRSA Benzoquinolizine Quinolone Agent: Review of Current Evidence.
Sachin S Bhagwat, Manohar Nandanwar, Atul Kansagara, Anusuya Patel, Swapna Takalkar, Rajesh Chavan

Drug Des Devel Ther· June 2020

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Single-Center Investigation of the Pharmacokinetics of WCK 4282 (Cefepime-Tazobactam Combination) in Renal Impairment.
Richard A Preston, Grigor Mamikonyan, Mushtaque Mastim, Dyal Garg, Christopher J Kemper, Rajesh Chavan

Antimicrob Agents Chemother· October 2019

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Safety, tolerability and pharmacokinetics of oral nafithromycin (WCK4873) after single or multiple doses and effects of food on single-dose bioavailability in healthy adult subjects.
Piotr Iwanowski, Ashima Bhatia, Mugdha Gupta, Anasuya Patel, Rajesh Chavan

Antimicrob Agents Chemother· September 2019

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Pharmacokinetic/Pharmacodynamic Targets of Levonadifloxacin against Staphylococcus aureus in a Neutropenic Murine Lung Infection Model.
Sachin S Bhagwat, Hariharan Periasamy, Swapna S Takalkar, Rajesh Chavan, Pavan Tayde

Antimicrob Agents Chemother· August 2019

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Identification of metabolites of novel Anti-MRSA fluoroquinolone WCK 771 in mouse, rat, rabbit, dog, monkey and human urine using liquid chromatography tandem mass spectrometry.
Ravindra D Yeole, Vipul P Rane, Vinod K Ahirrao, Rajesh P Chavan, Anasuya M Patel

Biomed Chromatogr· July 2019

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Single-Center Evaluation of the Pharmacokinetics of WCK 5222 (Cefepime-Zidebactam Combination) in Subjects with Renal Impairment.
Richard A Preston, Grigor Mamikonyan, Stephane DeGraff, James Chiou, Christopher J Kemper, Rajesh Chavan

Antimicrob Agents Chemother· January 2019

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Simultaneous determination of zidebactam and cefepime in dog plasma by LC-MS/MS and its application to pre-clinical pharmacokinetic study.
Kiran Patil, Harshad Tambe, Vineet Zope, Rajesh Chavan, Ravindra Yeole

Biomed Chromatogr· August 2018

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Plasma and Intrapulmonary Concentrations of Cefepime and Zidebactam following Intravenous Administration of WCK 5222 to Healthy Adult Subjects.
Keith A Rodvold, Mark H Gotfried, Rakesh Chugh, Mugdha Gupta, Anasuya Patel, Rajesh Chavan

Antimicrob Agents Chemother· August 2018

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Role of cancer antigen-125 from pleural & ascitic fluid samples in non malignant conditions.
Yatiraj Kalantri, Girish Naik, S P Joshi, Ajay Jain, Satish Phatak, Rajesh Chavan

Indian J Med Res· January 2007

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