Publications by authors named "Rajesh K Dutta"

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Sour taste sensation as a neuroimmune modulator in liver injury.
Rajesh K Dutta, Jude Oben, Anna Mae Diehl

J Hepatol· September 2025

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Dysregulated RNA splicing impairs regeneration in alcohol-associated liver disease.
Ullas V Chembazhi, Sushant Bangru, Rajesh Kumar Dutta, Diptatanu Das, Brandon Peiffer

Nat Commun· September 2025

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Author Correction: Targeting senescent hepatocytes for treatment of metabolic dysfunction-associated steatotic liver disease and multi-organ dysfunction.
Kuo Du, David S Umbaugh, Liuyang Wang, Ji Hye Jun, Rajesh K Dutta

Nat Commun· May 2025

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Targeting senescent hepatocytes for treatment of metabolic dysfunction-associated steatotic liver disease and multi-organ dysfunction.
Kuo Du, David S Umbaugh, Liuyang Wang, Ji Hye Jun, Rajesh K Dutta

Nat Commun· March 2025

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A systemic effect for liver senescence.
Kuo Du, David Scott Umbaugh, Rajesh Kumar Dutta, Anna Mae Diehl

Nat Cell Biol· December 2024

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The senescence-associated secretome of Hedgehog-deficient hepatocytes drives MASLD progression.
Ji Hye Jun, Kuo Du, Rajesh Kumar Dutta, Raquel Maeso-Diaz, Seh Hoon Oh

J Clin Invest· August 2024

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Aging promotes metabolic dysfunction-associated steatotic liver disease by inducing ferroptotic stress.
Kuo Du, Liuyang Wang, Ji Hye Jun, Rajesh K Dutta, Raquel Maeso-Díaz

Nat Aging· July 2024

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Plasticity, heterogeneity, and multifunctionality of hepatic stellate cells in liver pathophysiology.
Kuo Du, Ji Hye Jun, Rajesh K Dutta, Anna Mae Diehl

Hepatol Commun· May 2024

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Hedgehog Signaling: Implications in Liver Pathophysiology.
Rajesh Kumar Dutta, JiHye Jun, Kuo Du, Anna Mae Diehl

Semin Liver Dis· November 2023

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Targeting senescent hepatocytes using the thrombomodulin-PAR1 inhibitor vorapaxar ameliorates NAFLD progression.
Raquel Maeso-Díaz, Kuo Du, Christopher Pan, Cynthia D Guy, Seh Hoon Oh, Rajesh K Dutta

Hepatology· October 2023

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Targeting YAP-mediated HSC death susceptibility and senescence for treatment of liver fibrosis.
Kuo Du, Raquel Maeso-Díaz, Seh Hoon Oh, Ergang Wang, Tianyi Chen, Rajesh Kumar Dutta

Hepatology· June 2023

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Aging reduces liver resiliency by dysregulating Hedgehog signaling.
Raquel Maeso-Díaz, George D Dalton, Sehhoon Oh, Kuo Du, Linda Tang, Rajesh K Dutta

Aging Cell· February 2022

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Dysregulation of the ESRP2-NF2-YAP/TAZ axis promotes hepatobiliary carcinogenesis in non-alcoholic fatty liver disease.
Jeongeun Hyun, Muthana Al Abo, Rajesh Kumar Dutta, Seh Hoon Oh, Kun Xiang

J Hepatol· September 2021

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Inhibiting xCT/SLC7A11 induces ferroptosis of myofibroblastic hepatic stellate cells but exacerbates chronic liver injury.
Kuo Du, Seh Hoon Oh, Rajesh K Dutta, Tianai Sun, Wen-Hsuan Yang

Liver Int· September 2021

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Withdrawal: -Inositol oxygenase overexpression accentuates generation of reactive oxygen species and exacerbates cellular injury following high glucose ambience: A new mechanism relevant to the pathogenesis of diabetic nephropathy.
Lin Sun, Rajesh K Dutta, Ping Xie, Yashpal S Kanwar

J Biol Chem· June 2019

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Beneficial Effects of -Inositol Oxygenase Deficiency in Cisplatin-Induced AKI.
Rajesh K Dutta, Vinay K Kondeti, Isha Sharma, Navdeep S Chandel, Susan E Quaggin

J Am Soc Nephrol· May 2017

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High Glucose-Induced Hypomethylation Promotes Binding of Sp-1 to Myo-Inositol Oxygenase: Implication in the Pathobiology of Diabetic Tubulopathy.
Isha Sharma, Rajesh K Dutta, Neel K Singh, Yashpal S Kanwar

Am J Pathol· April 2017

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myo-Inositol Oxygenase Overexpression Accentuates Generation of Reactive Oxygen Species and Exacerbates Cellular Injury following High Glucose Ambience: A NEW MECHANISM RELEVANT TO THE PATHOGENESIS OF DIABETIC NEPHROPATHY.
Lin Sun, Rajesh K Dutta, Ping Xie, Yashpal S Kanwar

J Biol Chem· March 2016

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Pentoxifylline triggers autophagy via ER stress response that interferes with Pentoxifylline induced apoptosis in human melanoma cells.
Kapil Sharma, Mohammad Ishaq, Gaurav Sharma, Mohammad Aslam Khan, Rajesh Kumar Dutta

Biochem Pharmacol· March 2016

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Transcriptional and Translational Modulation of myo-Inositol Oxygenase (Miox) by Fatty Acids: IMPLICATIONS IN RENAL TUBULAR INJURY INDUCED IN OBESITY AND DIABETES.
Tatsuya Tominaga, Rajesh K Dutta, Darukeshwara Joladarashi, Toshio Doi, Janardan K Reddy

J Biol Chem· January 2016

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Gambogic acid induced oxidative stress dependent caspase activation regulates both apoptosis and autophagy by targeting various key molecules (NF-κB, Beclin-1, p62 and NBR1) in human bladder cancer cells.
Mohammad Ishaq, Mohammad Aslam Khan, Kapil Sharma, Gaurav Sharma, Rajesh Kumar Dutta

Biochim Biophys Acta· December 2014

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IL-27 inhibits IFN-γ induced autophagy by concomitant induction of JAK/PI3 K/Akt/mTOR cascade and up-regulation of Mcl-1 in Mycobacterium tuberculosis H37Rv infected macrophages.
Gaurav Sharma, Rajesh Kumar Dutta, Mohammad Aslam Khan, Mohammad Ishaq, Kapil Sharma

Int J Biochem Cell Biol· October 2014

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IL-6 inhibits IFN-γ induced autophagy in Mycobacterium tuberculosis H37Rv infected macrophages.
Rajesh Kumar Dutta, Mahesh Kathania, Manoj Raje, Sekhar Majumdar

Int J Biochem Cell Biol· June 2012

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Mass spectrometry assay for studying kinetic properties of dipeptidases: characterization of human and yeast dipeptidases.
Vaibhav Pandya, Mary Krishna Ekka, Rajesh Kumar Dutta, S Kumaran

Anal Biochem· November 2011

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Bfl-1/A1 acts as a negative regulator of autophagy in mycobacteria infected macrophages.
Mahesh Kathania, Chaaya Iyengar Raje, Manoj Raje, Rajesh Kumar Dutta, Sekhar Majumdar

Int J Biochem Cell Biol· April 2011

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