Publications by authors named "Raji Joseph"

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Impact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia.
Raji E Joseph, Thomas E Wales, Sandrine Jayne, Robert G Britton, D Bruce Fulton

Elife· December 2024

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Impact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia.
Raji E Joseph, Thomas E Wales, Sandrine Jayne, Robert G Britton, D Bruce Fulton

bioRxiv· October 2024

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Exploring 2-Sulfonylpyrimidine Warheads as Acrylamide Surrogates for Targeted Covalent Inhibition: A BTK Story.
Ruxandra Moraru, Beatriz Valle-Argos, Annabel Minton, Lara Buermann, Suyin Pan, Raji E Joseph

J Med Chem· August 2024

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Evolving Trends in Hepatocellular Carcinoma in a Multi-Cultural Australian Tertiary Centre.
Jack McNamara, Raji Joseph, Elisabeth Stratton, Miriam T Levy, Emilia Prakoso

J Gastrointest Cancer· March 2024

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Screening and Characterization of Allosteric Small Molecules Targeting Bruton's Tyrosine Kinase.
Lauren E Kueffer, David Yin-Wei Lin, Neha Amatya, Joseph Serrenho, Raji E Joseph

Biochemistry· January 2024

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The Conformational State of the BTK Substrate PLCγ Contributes to Ibrutinib Resistance.
Raji E Joseph, Jacques Lowe, D Bruce Fulton, John R Engen, Thomas E Wales

J Mol Biol· March 2022

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Conformational switches that control the TEC kinase - PLCγ signaling axis.
Jacques Lowe, Raji E Joseph, Amy H Andreotti

J Struct Biol X· January 2022

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Reining in BTK: Interdomain Interactions and Their Importance in the Regulatory Control of BTK.
Lauren E Kueffer, Raji E Joseph, Amy H Andreotti

Front Cell Dev Biol· June 2021

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Differential impact of BTK active site inhibitors on the conformational state of full-length BTK.
Raji E Joseph, Neha Amatya, D Bruce Fulton, John R Engen, Thomas E Wales

Elife· November 2020

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Lipid-targeting pleckstrin homology domain turns its autoinhibitory face toward the TEC kinases.
Neha Amatya, Thomas E Wales, Annie Kwon, Wayland Yeung, Raji E Joseph

Proc Natl Acad Sci U S A· October 2019

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Multidomain Control Over TEC Kinase Activation State Tunes the T Cell Response.
Amy H Andreotti, Raji E Joseph, James M Conley, Janet Iwasa, Leslie J Berg

Annu Rev Immunol· April 2018

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Achieving a Graded Immune Response: BTK Adopts a Range of Active/Inactive Conformations Dictated by Multiple Interdomain Contacts.
Raji E Joseph, Thomas E Wales, D Bruce Fulton, John R Engen, Amy H Andreotti

Structure· October 2017

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An Autoinhibitory Role for the Pleckstrin Homology Domain of Interleukin-2-Inducible Tyrosine Kinase and Its Interplay with Canonical Phospholipid Recognition.
Sujan Devkota, Raji E Joseph, Scott E Boyken, D Bruce Fulton, Amy H Andreotti

Biochemistry· June 2017

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Dynamics of the Tec-family tyrosine kinase SH3 domains.
Justin M Roberts, Sreya Tarafdar, Raji E Joseph, Amy H Andreotti, Thomas E Smithgall

Protein Sci· April 2016

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Dynamic Allostery Mediated by a Conserved Tryptophan in the Tec Family Kinases.
Nikita Chopra, Thomas E Wales, Raji E Joseph, Scott E Boyken, John R Engen

PLoS Comput Biol· March 2016

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Scaffold Protein SLP-76 Primes PLCγ1 for Activation by ITK-Mediated Phosphorylation.
Sujan Devkota, Raji E Joseph, Lie Min, D Bruce Fulton, Amy H Andreotti

J Mol Biol· August 2015

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A conserved isoleucine maintains the inactive state of Bruton's tyrosine kinase.
Scott E Boyken, Nikita Chopra, Qian Xie, Raji E Joseph, Thomas E Wales

J Mol Biol· October 2014

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Activation loop dynamics determine the different catalytic efficiencies of B cell- and T cell-specific tec kinases.
Raji E Joseph, Iivari Kleino, Thomas E Wales, Qian Xie, D Bruce Fulton

Sci Signal· August 2013

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Substrate recognition of PLCγ1 via a specific docking surface on Itk.
Qian Xie, Raji E Joseph, D Bruce Fulton, Amy H Andreotti

J Mol Biol· February 2013

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Structure of the interleukin-2 tyrosine kinase Src homology 2 domain; comparison between X-ray and NMR-derived structures.
Raji E Joseph, Nathaniel D Ginder, Julie A Hoy, Jay C Nix, D Bruce Fulton

Acta Crystallogr Sect F Struct Biol Cryst Commun· February 2012

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Purification, crystallization and preliminary crystallographic analysis of the SH2 domain of IL-2-inducible T-cell kinase.
Raji E Joseph, Nathaniel D Ginder, Julie A Hoy, Jay C Nix, Richard B Honzatko

Acta Crystallogr Sect F Struct Biol Cryst Commun· February 2011

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Controlling the activity of the Tec kinase Itk by mutation of the phenylalanine gatekeeper residue.
Raji E Joseph, Amy H Andreotti

Biochemistry· January 2011

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Identification of an allosteric signaling network within Tec family kinases.
Raji E Joseph, Qian Xie, Amy H Andreotti

J Mol Biol· October 2010

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T-cell signaling regulated by the Tec family kinase, Itk.
Amy H Andreotti, Pamela L Schwartzberg, Raji E Joseph, Leslie J Berg

Cold Spring Harb Perspect Biol· July 2010

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Disrupting the intermolecular self-association of Itk enhances T cell signaling.
Lie Min, Wenfang Wu, Raji E Joseph, D Bruce Fulton, Leslie Berg

J Immunol· April 2010

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