Publications by authors named "Rakan El-Mayta"

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Mannich reaction-based combinatorial libraries identify antioxidant ionizable lipids for mRNA delivery with reduced immunogenicity.
Ningqiang Gong, Dongyoon Kim, Mohamad-Gabriel Alameh, Rakan El-Mayta, Emily L Han

Nat Biomed Eng· December 2025

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Author Correction: Mannich reaction-based combinatorial libraries identify antioxidant ionizable lipids for mRNA delivery with reduced immunogenicity.
Ningqiang Gong, Dongyoon Kim, Mohamad-Gabriel Alameh, Rakan El-Mayta, Emily L Han

Nat Biomed Eng· December 2025

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Author Correction: Branched endosomal disruptor (BEND) lipids mediate delivery of mRNA and CRISPR-Cas9 ribonucleoprotein complex for hepatic gene editing and T cell engineering.
Marshall S Padilla, Kaitlin Mrksich, Yiming Wang, Rebecca M Haley, Jacqueline J Li, Rakan El-Mayta

Nat Commun· October 2025

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Comparative Analysis of Chitosan, Lipid Nanoparticles, and Alum Adjuvants in Recombinant SARS-CoV-2 Vaccine: An Evaluation of Their Immunogenicity and Serological Efficacy.
Majed Ghattas, Garima Dwivedi, Anik Chevrier, Trevor Scobey, Rakan El-Mayta

Vaccines (Basel)· July 2025

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Lipid Nanoparticles for Lung Delivery of CRISPR-Cas9 Ribonucleoproteins Allow Gene Editing of Clinical Targets.
Rebecca M Haley, Marshall S Padilla, Rakan D El-Mayta, Ryann A Joseph, Jesse A Weber

ACS Nano· April 2025

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Combinatorial design of siloxane-incorporated lipid nanoparticles augments intracellular processing for tissue-specific mRNA therapeutic delivery.
Lulu Xue, Gan Zhao, Ningqiang Gong, Xuexiang Han, Sarah J Shepherd, Rakan El-Mayta

Nat Nanotechnol· January 2025

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Branched endosomal disruptor (BEND) lipids mediate delivery of mRNA and CRISPR-Cas9 ribonucleoprotein complex for hepatic gene editing and T cell engineering.
Marshall S Padilla, Kaitlin Mrksich, Yiming Wang, Rebecca M Haley, Jacqueline J Li, Rakan El-Mayta

Nat Commun· January 2025

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Tumour-derived small extracellular vesicles act as a barrier to therapeutic nanoparticle delivery.
Ningqiang Gong, Wenqun Zhong, Mohamad-Gabriel Alameh, Xuexiang Han, Lulu Xue, Rakan El-Mayta

Nat Mater· December 2024

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Optimization of the activity and biodegradability of ionizable lipids for mRNA delivery via directed chemical evolution.
Xuexiang Han, Mohamad-Gabriel Alameh, Ying Xu, Rohan Palanki, Rakan El-Mayta

Nat Biomed Eng· November 2024

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Fast and facile synthesis of amidine-incorporated degradable lipids for versatile mRNA delivery in vivo.
Xuexiang Han, Mohamad-Gabriel Alameh, Ningqiang Gong, Lulu Xue, Majed Ghattas, Rakan El-Mayta

Nat Chem· October 2024

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Enhancing in situ cancer vaccines using delivery technologies.
Ningqiang Gong, Mohamad-Gabriel Alameh, Rakan El-Mayta, Lulu Xue, Drew Weissman

Nat Rev Drug Discov· August 2024

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High-Throughput Screening Identifies Differential Influences on mRNA Lipid Nanoparticle Immune Cell Delivery by Administration Route.
Alex G Hamilton, Kelsey L Swingle, Ajay S Thatte, Alvin J Mukalel, Hannah C Safford, Rakan D El-Mayta

ACS Nano· June 2024

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Small-molecule-mediated control of the anti-tumour activity and off-tumour toxicity of a supramolecular bispecific T cell engager.
Ningqiang Gong, Xuexiang Han, Lulu Xue, Margaret M Billingsley, Xisha Huang, Rakan El-Mayta

Nat Biomed Eng· May 2024

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Author Correction: Small-molecule-mediated control of the anti-tumour activity and off-tumour toxicity of a supramolecular bispecific T cell engager.
Ningqiang Gong, Xuexiang Han, Lulu Xue, Margaret M Billingsley, Xisha Huang, Rakan El-Mayta

Nat Biomed Eng· May 2024

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In Vivo mRNA CAR T Cell Engineering via Targeted Ionizable Lipid Nanoparticles with Extrahepatic Tropism.
Margaret M Billingsley, Ningqiang Gong, Alvin J Mukalel, Ajay S Thatte, Rakan El-Mayta

Small· March 2024

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An immunosuppressive vascular niche drives macrophage polarization and immunotherapy resistance in glioblastoma.
Fan Yang, Md Naushad Akhtar, Duo Zhang, Rakan El-Mayta, Junyoung Shin

Sci Adv· March 2024

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In situ combinatorial synthesis of degradable branched lipidoids for systemic delivery of mRNA therapeutics and gene editors.
Xuexiang Han, Junchao Xu, Ying Xu, Mohamad-Gabriel Alameh, Lulu Xue, Rakan El-Mayta

Nat Commun· February 2024

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High-throughput barcoding of nanoparticles identifies cationic, degradable lipid-like materials for mRNA delivery to the lungs in female preclinical models.
Lulu Xue, Alex G Hamilton, Gan Zhao, Zebin Xiao, Rakan El-Mayta

Nat Commun· February 2024

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Bile acid-containing lipid nanoparticles enhance extrahepatic mRNA delivery.
Savan K Patel, Margaret M Billingsley, Alvin J Mukalel, Ajay S Thatte, Alex G Hamilton, Rakan El-Mayta

Theranostics· January 2024

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In situ PEGylation of CAR T cells alleviates cytokine release syndrome and neurotoxicity.
Ningqiang Gong, Xuexiang Han, Lulu Xue, Rakan El-Mayta, Ann E Metzloff

Nat Mater· December 2023

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Throughput-scalable manufacturing of SARS-CoV-2 mRNA lipid nanoparticle vaccines.
Sarah J Shepherd, Xuexiang Han, Alvin J Mukalel, Rakan El-Mayta, Ajay S Thatte

Proc Natl Acad Sci U S A· August 2023

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In vivo bone marrow microenvironment siRNA delivery using lipid-polymer nanoparticles for multiple myeloma therapy.
Pedro P G Guimarães, Christian G Figueroa-Espada, Rachel S Riley, Ningqiang Gong, Lulu Xue, Rakan El-Mayta

Proc Natl Acad Sci U S A· June 2023

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Doxorubicin-conjugated siRNA lipid nanoparticles for combination cancer therapy.
Kamila Butowska, Xuexiang Han, Ningqiang Gong, Rakan El-Mayta, Rebecca M Haley

Acta Pharm Sin B· April 2023

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Ligand-tethered lipid nanoparticles for targeted RNA delivery to treat liver fibrosis.
Xuexiang Han, Ningqiang Gong, Lulu Xue, Margaret M Billingsley, Rakan El-Mayta

Nat Commun· January 2023

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Testing the In Vitro and In Vivo Efficiency of mRNA-Lipid Nanoparticles Formulated by Microfluidic Mixing.
Rakan El-Mayta, Marshall S Padilla, Margaret M Billingsley, Xuexiang Han, Michael J Mitchell

J Vis Exp· January 2023

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