Publications by authors named "Ralf Plate"

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Org 214007-0: a novel non-steroidal selective glucocorticoid receptor modulator with full anti-inflammatory properties and improved therapeutic index.
Marie-José C van Lierop, Wynand Alkema, Anke J Laskewitz, Rein Dijkema, Hans M van der Maaden, Ralf Plate

PLoS One· May 2013

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Complete inhibition of rhTSH-, Graves' disease IgG-, and M22-induced cAMP production in differentiated orbital fibroblasts by a low-molecular-weight TSHR antagonist.
Clementine J J van Zeijl, Chris J van Koppen, Olga V Surovtseva, Marcel E de Gooyer, Ralf Plate

J Clin Endocrinol Metab· May 2012

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Mechanism of action of a nanomolar potent, allosteric antagonist of the thyroid-stimulating hormone receptor.
Chris J van Koppen, Marcel E de Gooyer, Willem-Jan Karstens, Ralf Plate, Paolo G M Conti

Br J Pharmacol· April 2012

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Application of a ligand-based theoretical approach to derive conversion paths and ligand conformations in CYP11B2-mediated aldosterone formation.
Luc Roumen, Bram Van Hoof, Koen Pieterse, Peter A J Hilbers, Erica M G Custers, Ralf Plate

J Comput Chem· August 2011

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Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2).
Luc Roumen, Joris W Peeters, Judith M A Emmen, Ilona P E Beugels, Erica M G Custers, Ralf Plate

J Med Chem· February 2010

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Fadrozole reverses cardiac fibrosis in spontaneously hypertensive heart failure rats: discordant enantioselectivity versus reduction of plasma aldosterone.
Monica Minnaard-Huiban, Judith M A Emmen, Luc Roumen, Ilona P E Beugels, Géraldine M S Cohuet, Ralf Plate

Endocrinology· January 2008

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Construction of 3D models of the CYP11B family as a tool to predict ligand binding characteristics.
Luc Roumen, Marijn P A Sanders, Koen Pieterse, Peter A J Hilbers, Ralf Plate

J Comput Aided Mol Des· August 2007

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Synthesis and in vitro muscarinic activities of a series of 1,3-diazacycloalkyl carboxaldehyde oxime derivatives.
Ralf Plate, Christan G J M Jans, Marc J M Plaum, Thijs de Boer

Bioorg Med Chem· April 2002

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